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Nihon rinsho. Japanese journal of clinical medicine, 2004
Here we investigated the biological functions of adiponectin, a fat-derived hormone, by disrupting the gene encodes it in mice. Adiponectin knockout mice (KO) exhibited severe diet-induced insulin resistance with reduced IRS-1-associated P13-kinase activity in muscle.
Norikazu, Maeda, Tohru, Funahashi
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Here we investigated the biological functions of adiponectin, a fat-derived hormone, by disrupting the gene encodes it in mice. Adiponectin knockout mice (KO) exhibited severe diet-induced insulin resistance with reduced IRS-1-associated P13-kinase activity in muscle.
Norikazu, Maeda, Tohru, Funahashi
openaire +1 more source
Generation of Conditional Knockout Mice
2014Conditional knockout mouse models are powerful tools to examine the biological and molecular function(s) of genes in specific tissues. The general procedure to generate such genetically engineered mouse models consists of three main steps. The first step is to find the appropriate genomic clone of the gene of interest and to design the cloning and ...
Kazuhito, Sakamoto +2 more
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Humanized mouse models for immuno-oncology research
Nature Reviews Clinical Oncology, 2023Michael A Brehm
exaly
The pathogenicity of SARS-CoV-2 in hACE2 transgenic mice
Nature, 2020Linlin Bao, Wei Deng, Hong Gao
exaly
Tissue-resident memory T cells in breast cancer control and immunotherapy responses
Nature Reviews Clinical Oncology, 2020Peter Savas, Ran Li, Balaji Virassamy
exaly