Results 341 to 350 of about 2,312,784 (355)

Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout mice.

Science, 1999
The function of the central cannabinoid receptor (CB1) was investigated by invalidating its gene. Mutant mice did not respond to cannabinoid drugs, demonstrating the exclusive role of the CB1 receptor in mediating analgesia, reinforcement, hypothermia ...
C. Ledent, O. Valverde, G. Cossu, F. Petitet, J. Aubert, F. Beslot, G. Böhme, A. Imperato, T. Pedrazzini, B. Roques, G. Vassart, W. Fratta, M. Parmentier   +12 more
semanticscholar   +1 more source

The role of an experimental model of atherosclerosis: apoE-knockout mice in developing new drugs against atherogenesis.

Current Pharmaceutical Biotechnology, 2012
Although atherosclerosis was previously thought to be mainly a degenerative disease, it is now well ascertained that its pathogenesis is inflammatory.
J. Jawień
semanticscholar   +1 more source

What's Wrong With My Mouse?: Behavioral Phenotyping of Transgenic and Knockout Mice

, 2000
array of choices available for assaying this behavioral construct, and seeing that there are somewhat murky borders between the constructs ‘anxiety’, ‘fear’ and ‘depression’, he or she will explore the question further with an array of tests, after ...
J. Crawley
semanticscholar   +1 more source

Generation of knockout mice by Cpf1-mediated gene targeting

Nature Biotechnology, 2016
Yongsub Kim, Seung-A. Cheong, Jong Geol Lee, Sang-Wook Lee, Myeong Sup Lee, In-Jeoung Baek, Y. Sung   +6 more
semanticscholar   +1 more source

Utility of Oatp1a/1b-Knockout and OATP1B1/3-Humanized Mice in the Study of OATP-Mediated Pharmacokinetics and Tissue Distribution: Case Studies with Pravastatin, Atorvastatin, Simvastatin, and Carboxydichlorofluorescein

Drug Metabolism And Disposition, 2014
J. W. Higgins, Jing Q. Bao, A. Ke, J. Manro, J. K. Fallon, Philip C. Smith, M. Zamek-Gliszczynski   +6 more
semanticscholar   +1 more source

Fmr1 knockout mice: A model to study fragile X mental retardation

Cell, 1994
The Dutch-Belgian Fragile X Consorthium, C. Bakker, C. Verheij, R. Willemsen, R. V. D. Helm, F. Oerlemans, M. Vermey, A. Bygrave, A. Hoogeveen, B. Oostra, E. Reyniers, Kristel De Boule, R. D'Hooge, P. Cras, D. V. Velzen, G. Nagels, Jean-Jacques Martin, P. Deyn, J. Darby, P. Willems   +19 more
semanticscholar   +1 more source

Impaired energy homeostasis in C/EBP alpha knockout mice

Science, 1995
Nd Wang, M. Finegold, A. Bradley, CN Ou, SV Abdelsayed, M. Wilde, L. Taylor, D. Wilson, GJ Darlington   +8 more
semanticscholar   +1 more source