Results 61 to 70 of about 2,060,910 (365)

Generation and Characterization of Rac3 Knockout Mice [PDF]

Molecular and Cellular Biology, 2005
Rac proteins are members of the Rho family of GTPases involved in the regulation of actin dynamics. The three highly homologous Rac proteins in mammals are the ubiquitous Rac1, the hematopoiesis-specific Rac2, and the least-characterized Rac3. We show here that Rac3 mRNA is widely and specifically expressed in the developing nervous system, with ...
Corbetta S, Gualdoni S, Albertinazzi C, Paris S, Croci L, CONSALEZ , GIAN GIACOMO, DE CURTIS , IVANMATTEO   +6 more
openaire   +4 more sources

Impaired monocyte migration and reduced type 1 (Th1) cytokine responses in C-C chemokine receptor 2 knockout mice.

Journal of Clinical Investigation, 1997
Monocyte chemoattractant protein-1 (MCP-1) is a potent agonist for mononuclear leukocytes and has been implicated in the pathogenesis of atherosclerosis and granulomatous lung disease. To determine the role of MCP-1 and related family members in vivo, we
L. Boring, J. Gosling, S. Chensue, S. Kunkel, Robert V Farese, H. Broxmeyer, I. Charo   +6 more
semanticscholar   +1 more source

The salivary protein BPIFA2 differentially regulates sodium preference and blood pressure in male and female mice

Experimental Results, 2020
BPIFA2 (PSP, SPLUNC2, C20orf70) is a major salivary protein of uncertain physiological function. BPIFA2 is downregulated in salivary glands of spontaneously hypertensive rats, pointing to a role in blood pressure regulation.
Sven-Ulrik Gorr, Michael Nevels
doaj   +1 more source

Knockout of the 15 kDa selenoprotein protects against chemically-induced aberrant crypt formation in mice. [PDF]

PLoS ONE, 2012
Evidence suggests that selenium has cancer preventive properties that are largely mediated through selenoproteins. Our previous observations demonstrated that targeted down-regulation of the 15 kDa selenoprotein (Sep15) in murine colon cancer cells ...
Petra A Tsuji, Bradley A Carlson, Salvador Naranjo-Suarez, Min-Hyuk Yoo, Xue-Ming Xu, Dmitri E Fomenko, Vadim N Gladyshev, Dolph L Hatfield, Cindy D Davis   +8 more
doaj   +1 more source

LRRK2 knockout mice have an intact dopaminergic system but display alterations in exploratory and motor co-ordination behaviors

Molecular Neurodegeneration, 2012
Mutations in the LRRK2 gene are the most common cause of genetic Parkinson’s disease. Although the mechanisms behind the pathogenic effects of LRRK2 mutations are still not clear, data emerging from in vitro and in vivo models suggests roles in ...
K. Hinkle, Mei Yue, B. Behrouz, J. Dächsel, S. Lincoln, Erin E. Bowles, Joel E. Beevers, B. Dugger, B. Winner, I. Prots, C. Kent, K. Nishioka, Wen‐lang Lin, D. Dickson, C. Janus, M. Farrer, H. Melrose   +16 more
semanticscholar   +1 more source

FoxO1 signaling in B cell malignancies and its therapeutic targeting

FEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac, Petra Pavelkova, Laura Ondrisova, Marek Mraz   +3 more
wiley   +1 more source

The immunological interface: dendritic cells as key regulators in metabolic dysfunction‐associated steatotic liver disease

FEBS Letters, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi, WanTing Kong, Camille Blériot, Joel T. Haas   +3 more
wiley   +1 more source

Immune Response in Stat2 Knockout Mice [PDF]

Immunity, 2000
Type I IFNs induce gene expression through Stat1 and Stat2, which can in turn associate either to form Stat1 homodimers or the transcription factor ISGF-3. Stat1 homodimers also transduce signals for IFN-gamma. To explore the unique properties of Stat2 and ISGF-3 in type I IFN signaling, its gene was targeted for deletion.
Christian Schindler, Edward Cha, Christopher Y. Park, Suzanne Li   +3 more
openaire   +3 more sources

An atlas of genetic influences on osteoporosis in humans and mice

Nature Genetics, 2018
Osteoporosis is a common aging-related disease diagnosed primarily using bone mineral density (BMD). We assessed genetic determinants of BMD as estimated by heel quantitative ultrasound in 426,824 individuals, identifying 518 genome-wide significant loci
John A. Morris, J. Kemp, Scott E. Youlten, Laetitia Laurent, J. Logan, R. Chai, Nicholas A. Vulpescu, Vincenzo Forgetta, A. Kleinman, Sindhu T. Mohanty, C. M. Sergio, J. Quinn, L. Nguyen-Yamamoto, Aimée-Lee Luco, Jinchu Vijay, Marie-Michelle Simon, A. Pramatarova, C. Medina-Gomez, K. Trajanoska, Elena J Ghirardello, N. Butterfield, Katharine F. Curry, V. D. Leitch, Penny C Sparkes, Anne-Tounsia Adoum, Naila S. Mannan, Davide Komla-Ebri, A. Pollard, Hannah F. Dewhurst, Thomas A. D. Hassall, Michael-John G. Beltejar, Michelle Babak Adam Robert K. Katarzyna Sarah L. Pierre Nic Agee Alipanahi Auton Bell Bryc Elson Fontanillas F, M. Agee, B. Alipanahi, A. Auton, R. Bell, K. Bryc, S. Elson, P. Fontanillas, N. Furlotte, J. McCreight, K. Huber, N. Litterman, M. Mcintyre, J. Mountain, E. Noblin, C. Northover, S. Pitts, J. Sathirapongsasuti, O. Sazonova, J. Shelton, S. Shringarpure, C. Tian, J. Tung, V. Vacic, C. H. Wilson, Douglas J. Adams, S. Vaillancourt, S. Kaptoge, P. Baldock, C. Cooper, J. Reeve, E. Ntzani, E. Evangelou, C. Ohlsson, D. Karasik, F. Rivadeneira, D. Kiel, J. Tobias, C. Gregson, N. Harvey, E. Grundberg, D. Goltzman, David J. Adams, C. Lelliott, D. Hinds, C. Ackert-Bicknell, Y. Hsu, M. Maurano, P. Croucher, G. Williams, J. Bassett, David M. Evans, J. B. Richards   +83 more
semanticscholar   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source