How to manage KPC infections [PDF]
Therapeutic Advances in Infectious Disease, 2020 Carbapenemase-producing Enterobacteriaceae represent an increasing global threat worldwide and Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae (KPC-KP) has become one of the most important contemporary pathogens, especially in endemic ...
M. Bassetti, M. Peghin
semanticscholar +6 more sources
Phenotypic and enzymatic comparative analysis of the KPC variants, KPC-2 and its recently discovered variant KPC-15. [PDF]
PLoS ONE, 2014 Sixteen different variants (KPC-2 to KPC-17) in the KPC family have been reported, and most current studies are focusing on KPC-2 and KPC-3. The KPC-15 variant, which isolated from Klebsiella pneumoniae in a Chinese hospital, was a recently discovered ...
Dongguo Wang +4 more
doaj +5 more sources
Unravelling ceftazidime/avibactam resistance of KPC-28, a KPC-2 variant lacking carbapenemase activity. [PDF]
Journal of Antimicrobial Chemotherapy, 2019 BACKGROUND KPC-like carbapenemases have spread worldwide with more than 30 variants identified that differ by single or double amino-acid substitutions. OBJECTIVES To describe the steady-state kinetic parameters of KPC-28, which differs from KPC-2 by a
S. Oueslati +9 more
semanticscholar +4 more sources
Management of KPC-producing Klebsiella pneumoniae infections. [PDF]
Clinical Microbiology and Infection, 2017 Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae (KPC-KP) has become one of the most important contemporary pathogens, especially in endemic ...
M. Bassetti +14 more
semanticscholar +10 more sources
A Novel KPC Variant KPC-55 in Klebsiella pneumoniae ST307 of Reinforced Meropenem-Hydrolyzing Activity [PDF]
Frontiers in Microbiology, 2020 A novel Klebsiella pneumoniae carbapenemase (KPC) variant, KPC-55, produced by a K. pneumoniae ST307 strain was characterized. K. pneumoniae strain BS407 was recovered from an active surveillance rectal swab of a patient newly admitted to a general ...
정석훈, 최종락
core +6 more sources
Identification of two KPC variants, KPC-204 and KPC-227, in ST11-K64 Klebsiella pneumoniae during prolonged hospitalization of a single patient [PDF]
Frontiers in MicrobiologyIntroductionCarbapenem-resistant Klebsiella pneumoniae (CRKP) represents a critical global public health challenge due to its significant association with morbidity and mortality.
Chaoe Zhou +6 more
core +4 more sources
Reduced mortality from KPC-K.pneumoniae bloodstream infection in high-risk patients with hematological malignancies colonized by KPC-K.pneumoniae [PDF]
BMC Infectious Diseases, 2020 KPC-K.pneumoniae bloodstream infection (KPC-KpBSI) mortality rate in patients with hematological malignancies is reported about 60%. The initial treatment active against KPC-K.pneumoniae is crucial for survival and KPC-K.pneumoniae rectal colonization ...
A. Micozzi +12 more
semanticscholar +2 more sources
Emergence of four cases of KPC-2 and KPC-3-carrying Klebsiella pneumoniae introduced to Switzerland, 2009-10 [PDF]
Eurosurveillance, 2011 We report four epidemiologically unrelated cases of KPC-carrying Klebsiella pneumoniae identified in Switzerland between May 2009 and November 2010. Three cases were transferred from Italy (two KPC-3, one KPC-2) and one from Greece (KPC-2). Resistance to
Droz, S +21 more
core +5 more sources
Relebactam Is a Potent Inhibitor of the KPC-2 β-Lactamase and Restores Imipenem Susceptibility in KPC-Producing Enterobacteriaceae [PDF]
Antimicrobial Agents and Chemotherapy, 2018 The imipenem-relebactam combination is in development as a potential treatment regimen for infections caused by Enterobacteriaceae possessing complex β-lactamase backgrounds.
Krisztina M. Papp-Wallace +9 more
core +3 more sources
Antimicrobial Agents and Chemotherapy, 2021 This study reports on the characterization of a Klebsiella pneumoniae clinical isolate showing high-level resistance to ceftazidime-avibactam associated with the production of KPC-53, a KPC-3 variant exhibiting a Leu167Glu168 duplication in the Ω-loop ...
Di Pilato V. +7 more
core +4 more sources