Results 11 to 20 of about 57,276 (230)

Phenotypic and enzymatic comparative analysis of the KPC variants, KPC-2 and its recently discovered variant KPC-15. [PDF]

PLoS ONE, 2014
Sixteen different variants (KPC-2 to KPC-17) in the KPC family have been reported, and most current studies are focusing on KPC-2 and KPC-3. The KPC-15 variant, which isolated from Klebsiella pneumoniae in a Chinese hospital, was a recently discovered ...
Linjun Yang (652707), Dongguo Wang (652706), Yonghua Mou, Jiayu Chen, Linjun Yang, Jiayu Chen (106469), Yonghua Mou (652708), Yijun Yang (187046), Dongguo Wang, Yijun Yang   +9 more
core   +5 more sources

How to manage KPC infections [PDF]

Therapeutic Advances in Infectious Disease, 2020
Carbapenemase-producing Enterobacteriaceae represent an increasing global threat worldwide and Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae (KPC-KP) has become one of the most important contemporary pathogens, especially in endemic ...
Matteo Bassetti, Bassetti, Matteo, Peghin, Maddalena, Maddalena Peghin   +3 more
core   +5 more sources

A Novel KPC Variant KPC-55 in Klebsiella pneumoniae ST307 of Reinforced Meropenem-Hydrolyzing Activity [PDF]

Frontiers in Microbiology, 2020
A novel Klebsiella pneumoniae carbapenemase (KPC) variant, KPC-55, produced by a K. pneumoniae ST307 strain was characterized. K. pneumoniae strain BS407 was recovered from an active surveillance rectal swab of a patient newly admitted to a general ...
정석훈, 최종락
core   +6 more sources

Emergence of four cases of KPC-2 and KPC-3-carrying Klebsiella pneumoniae introduced to Switzerland, 2009-10 [PDF]

Eurosurveillance, 2011
We report four epidemiologically unrelated cases of KPC-carrying Klebsiella pneumoniae identified in Switzerland between May 2009 and November 2010. Three cases were transferred from Italy (two KPC-3, one KPC-2) and one from Greece (KPC-2). Resistance to
Droz, S, S Droz, C Garzoni, Widmer, A F, Führer, U, Babouee, B, Goldenberger, D, B Babouee, R Frei, Dubuis, O, Frei, R, Ciardo, D, O Dubuis, Garzoni, C, Betsch, B Y, U Führer, A F Widmer, D Goldenberger, Battegay, M, B Y Betsch, D Ciardo, M Battegay   +21 more
core   +6 more sources

Unravelling ceftazidime/avibactam resistance of KPC-28, a KPC-2 variant lacking carbapenemase activity [PDF]

Journal of Antimicrobial Chemotherapy, 2019
International audienceBACKGROUND:KPC-like carbapenemases have spread worldwide with more than 30 variants identified that differ by single or double amino-acid substitutions.OBJECTIVES:To describe the steady-state kinetic parameters of KPC-28, which ...
Tlili, Linda, Jousset, Agnès, Zavala, Agustin, Dortet, Laurent, Bernabeu, Sandrine, Naas, Thierry, Exilie, Cynthia, Oueslati, Saoussen, Iorga, Bogdan, Bonnin, Rémy   +9 more
core   +3 more sources

Identification of two KPC variants, KPC-204 and KPC-227, in ST11-K64 Klebsiella pneumoniae during prolonged hospitalization of a single patient [PDF]

Frontiers in Microbiology
IntroductionCarbapenem-resistant Klebsiella pneumoniae (CRKP) represents a critical global public health challenge due to its significant association with morbidity and mortality.
Chaoe Zhou, Wanhai Wang, Saiqi Qi, Liying Sun, Shijun Sun, Haijun Li, Xinmin Liu   +6 more
core   +4 more sources

Management of KPC-Producing Klebsiella pneumoniae Infections [PDF]

Clinical Microbiology and Infection, 2017
Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae (KPC-KP) has become one of the most important contemporary pathogens, especially in endemic ...
E.J. Giamarellos-Bourboulis, Giacobbe, D. R, Nicolau, D. P., Viale, P. L., Giamarellos-Bourboulis EJ, Tumbarello, M, H. Giamarellou, Daikos, G. L, I. Karaiskos, Viale, P. L, De Rosa, F. G., G. Poulakou, D.R. Giacobbe, Righi E, Giacobbe, D. R., Tumbarello, M., Giamarellou, H., Dimopoulos, G., C. Viscoli, Karaiskos I, BASSETTI, MATTEO, Karaiskos, I, Bassetti M, M. Bassetti, G.M. Rossolini, Karaiskos, I., Viscoli, C, F.G. De Rosa, Giamarellos-Bourboulis, E. J., De Rosa, F. G, E. Righi, Giacobbe DR, Giamarellos Bourboulis, E. J, D.P. Nicolau, De Rosa FG, Rossolini GM, Rossolini, G. M, Viscoli C, Righi, E., Rossolini, G. M., Daikos GL, Poulakou, G., M. Tumbarello, Giamarellou, H, Tumbarello M, Nicolau DP, Poulakou G, G. Dimopoulos, Viscoli, C., Viale PL, Giamarellou H, Nicolau, D. P, P.L. Viale, Dimopoulos, G, G.L. Daikos, Dimopoulos G, Righi, E, Bassetti, M., Daikos, G. L.   +58 more
core   +10 more sources

Relebactam Is a Potent Inhibitor of the KPC-2 β-Lactamase and Restores Imipenem Susceptibility in KPC-Producing Enterobacteriaceae [PDF]

Antimicrobial Agents and Chemotherapy, 2018
The imipenem-relebactam combination is in development as a potential treatment regimen for infections caused by Enterobacteriaceae possessing complex β-lactamase backgrounds.
Krisztina M. Papp-Wallace, Keith S. Kaye, David van Duin, Melissa D. Barnes, Robert A. Bonomo, Jim Alsop, Magdalena A. Taracila, Scott A. Becka, Christopher R. Bethel, Barry N. Kreiswirth   +9 more
core   +3 more sources

A High-Affinity Nanobody Selectively Recognizing KPC-2/KPC-3: Biochemical and Structural Insights

Biomolecules
International audienceCarbapenemase-producing bacteria, particularly those expressing the KPC-3 variant, pose a critical global health threat due to their resistance to nearly all β-lactam antibiotics, including carbapenems.
Perilli, Mariagrazia, Ben Abderrazek, Rahma, Saihi, Mohamed, Hedi, Brisdelli, Fabrizia, Bouhaouala-Zahar, Balkiss, Dhaouadi, Sayda, Khamessi, Oussema, Dabbek, Hafedh, Zarrouk, Sinda, Hamdi, Emna, Piccirilli, Alessandra   +10 more
core   +3 more sources

Emergence of ceftazidime-avibactam resistance mediated by KPC variants KPC-71 and KPC-78 in ST463 <i>Pseudomonas aeruginosa</i>. [PDF]

Microbiol Spectr
ABSTRACT Pseudomonas aeruginosa is a well-recognized opportunistic pathogen and a leading cause of healthcare-associated infections. The shrinking effectiveness of available antimicrobial therapies has intensified the global threat posed by ...
Yang F, Sun Y, Chen W, Shen D, Zhu J, Sun Z, Cai Y, Zhang Y, Shen H, Sun F, Xiao Y, Jiang C, Cui Z.   +12 more
europepmc   +2 more sources