Results 21 to 30 of about 85,174 (277)

Phenotypic and Enzymatic Comparative Analysis of the Novel KPC Variant KPC-5 and Its Evolutionary Variants, KPC-2 and KPC-4 [PDF]

open access: yesAntimicrobial Agents and Chemotherapy, 2009
ABSTRACT A novel Klebsiella pneumoniae carbapenemase (KPC) variant, designated bla KPC-5 , was discovered in a carbapenem-resistant Pseudomonas aeruginosa clinical isolate from Puerto Rico.
Daniel J, Wolter   +5 more
openaire   +2 more sources

Resistance to ceftazidime/avibactam in infections and colonizations by KPC-producing Enterobacterales: a systematic review of observational clinical studies.

open access: yesJournal of Global Antimicrobial Resistance, 2021
Ceftazidime/avibactam (CAZ-AVI), approved in 2015, is an important first-line option for KPC-producing Enterobacterales (KPC-E). Although still uncommon, resistance to CAZ-AVI has emerged and may represents a serious cause of concern.
Stefano Di Bella   +7 more
semanticscholar   +1 more source

Structural Characterization of the D179N and D179Y Variants of KPC-2 β-Lactamase: Ω-Loop Destabilization as a Mechanism of Resistance to Ceftazidime-Avibactam

open access: yesAntimicrobial Agents and Chemotherapy, 2022
Klebsiella pneumoniae carbapenemases (KPC-2 and KPC-3) present a global clinical threat, as these β-lactamases confer resistance to carbapenems and oxyimino-cephalosporins.
T. A. Alsenani   +11 more
semanticscholar   +1 more source

Increased blaKPC Copy Number and OmpK35 and OmpK36 Porins Disruption Mediated Resistance to Imipenem/Relebactam and Meropenem/Vaborbactam in a KPC-Producing Klebsiella pneumoniae Clinical Isolate

open access: yesAntimicrobial Agents and Chemotherapy, 2022
Herein, we report the in vivo evolution of imipenem/relebactam-resistance in KPC-producing K. pneumoniae (KPC-Kp) isolated from a critically-ill patient treated with multiple combination therapies based on ceftazidime-avibactam or meropenem-vaborbactam ...
P. Gaibani   +5 more
semanticscholar   +1 more source

Dissemination of Carbapenemases (KPC, NDM, OXA-48, IMP, and VIM) Among Carbapenem-Resistant Enterobacteriaceae Isolated From Adult and Children Patients in China

open access: yesFrontiers in Cellular and Infection Microbiology, 2020
This study aimed to investigate the dissemination and characteristics of blaKPC, blaNDM, blaOXA-48-like, blaIMP, and blaVIM among the carbapenem-resistant Enterobacteriaceae (CRE) strains isolated from adult and children patients.
Renru Han   +9 more
semanticscholar   +1 more source

Cross resistance to cefiderocol and ceftazidime-avibactam in KPC beta-lactamase mutants and inoculum effect.

open access: yesClinical Microbiology and Infection, 2021
OBJECTIVES Ceftazidime-avibactam and cefiderocol are recently commercialized molecules active against highly drug-resistant bacteria, including carbapenem-resistant Enterobacteriaceae. Resistant mutants to ceftazidime-avibactam were described and notably
C. Hobson   +8 more
semanticscholar   +1 more source

Evaluation of the Ability to Form Biofilms in KPC-Producing and ESBL-Producing Klebsiella pneumoniae Isolated from Clinical Samples [PDF]

open access: yes, 2023
The appearance of Klebsiella pneumoniae strains producing extended-spectrum β-lactamase (ESBL), and carbapenemase (KPC) has turned into a significant public health issue. ESBL- and KPC-producing K.
Sónia Ramos   +17 more
core   +1 more source

THE STAR FORMATION LAW IN NEARBY GALAXIES ON SUB-KPC SCALES [PDF]

open access: yes, 2008
We present a comprehensive analysis of the relationship between star formation rate surface density, ΣSFR, and gas surface density, Σgas, at sub-kpc resolution in a sample of 18 nearby galaxies.
F. Bigiel   +6 more
semanticscholar   +1 more source

A novel KPC-113 variant conferring carbapenem and ceftazidime-avibactam resistance in a multidrug-resistant Pseudomonas aeruginosa isolate.

open access: yesClinical Microbiology and Infection, 2022
OBJECTIVES This study aimed to characterize a novel KPC-113 variant from a clinical Pseudomonas aeruginosa isolate R20-14. METHODS Genomic DNA of R20-14 was subjected to Illumina and Oxford Nanopore sequencing.
Qing Yang   +7 more
semanticscholar   +1 more source

Time to appropriate antibiotic therapy is a predictor of outcome in patients with bloodstream infection caused by KPC-producing Klebsiella pneumoniae

open access: yesCritical Care, 2020
Bloodstream infections (BSIs) by Klebsiella pneumoniae carbapenemase (KPC)-producing Klebsiella pneumoniae (Kp) are associated with high mortality.
M. Falcone   +11 more
semanticscholar   +1 more source

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