Results 41 to 50 of about 161,113 (157)

Efficacy and Safety Assessment of 5‐Fluorouracil, Irinotecan and Oxaliplatin‐Loaded Implants in Mouse and Pig Models for Pancreatic Cancer Therapy

Advanced Materials, EarlyView.
A novel FIRINOX‐loaded implant demonstrates controlled drug release, and potent therapeutic efficacy in pancreatic ductal adenocarcinoma mouse models with safety confirmed in a large‐animal pre‐clinical model. This innovative drug delivery platform offers a promising new treatment approach for non‐resectable, treatment‐resistant pancreatic cancer ...
Samantha J. Wade, Ashna A. Kumar, Samuel O. Nitschke, Paul Joyce, Elahe Minaei, Stephanie E. Reuter Lange, Chelsea Penney, Holly Warren, Ruby Shepherd, Jeremy N. Dinoro, Gordon G. Wallace, Anthony Dosseto, Sameera Ansar, Naila Islam, Alistair Lochhead, George Sharbeen, Phoebe A. Phillips, Morteza Aghmesheh, Wayne J. Hawthorne, Kara L. Vine‐Perrow   +19 more
wiley   +1 more source

Global properties of the HI distribution in the outer Milky Way

, 2008
Aims: We derive the 3-D HI volume density distribution for the Galactic disk out to R = 60 kpc. Methods: Our analysis is based on parameters for the warp and rotation curve derived previously.
Albert, Bajaja, Boulares, Collins, Cox, Dame, de Avillez, de Boer, Dehnen, Dickey, Diplas, Fraternali, Fraternali, Fraternali, Haud, Heald, Henderson, Kalberla, Kalberla, Kalberla, Kalberla, Kalberla, Kuijken, Kulkarni, Kulkarni, L. Dedes, Levine, Levine, Lockman, Lockman, Lockman, Lockman, Lockman, Lockman, Maloney, McClure-Griffiths, Mohan, Münch, Nakanishi, Oosterloo, P. M. W. Kalberla, Pikelner, Radhakrishnan, Saha, Spitzer, Spitzer, Stanimirovic, Stark, Stil, Swaters, Twarog, Wakker, Weinberg, Weiner, Wolfire, Wouterloot   +55 more
core   +1 more source

Mitochondrial Calcium Uniporter Drives Chemoresistance in Pancreatic Cancer via Glutathione‐Mediated Stemness Maintenance

Advanced Science, EarlyView.
PDAC has a poor prognosis due to chemoresistance. We revealed that MCU upregulation is associated with chemoresistance and stemness in PDAC. MCU‐mediated Ca2+ influx induced ER stress, activating the PERK‐ATF4/NRF2 axis to enhance PSAT1/SLC711 expression and glutathione synthesis, reducing ROS and maintaining stemness.
Zekun Li, Chenyang Meng, Guangcong Shen, Yueying Shan, Junjin Wang, Diliyaer Abudukeremu, Rui Zhao, Bo Ni, Chao Xu, Xiaofan Guo, Jun Yu, Kaiyuan Wang, Shengyu Yang, YunZhan Li, Yongjie Xie, Tianxing Zhou, Jihui Hao, Xiuchao Wang   +17 more
wiley   +1 more source

In vitro Combined Inhibitory Activities of β-Lactam Antibiotics and Clavulanic Acid Against blaKPC-2-Positive Klebsiella pneumoniae

Infection and Drug Resistance, 2021
Mingjia Peng,1,2 Renru Han,1,2 Yan Guo,1,2 Yonggui Zheng,1,2 Feifei Yang,1,2 Xiaogang Xu,1,2 Fupin Hu1,2 1Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, People’s Republic of China; 2Key Laboratory of Clinical Pharmacology ...
Peng M, Han R, Guo Y, Zheng Y, Yang F, Xu X, Hu F   +6 more
doaj  

Discovery of Radio Emission from the Quasar SDSS J1536+0441, a Candidate Binary Black-Hole System

, 2009
The radio-quiet quasar SDSS J1536+0441 shows two broad-line emission systems that Boroson & Lauer interpret as a candidate binary black-hole system with a separation of 0.1 pc (0.02 mas). From new VLA imaging at 8.5 GHz, two faint sources, separated by 0.
A. Laor, Arzoumananian, Barvainis, Brinkman, Chornock, Condon, Gaskell, Hennawi, Ivesic, J. M. Wrobel, Komossa, Rodriguez, Salvato, Ulvestad, Wang, White   +15 more
core   +1 more source

Stellar structures in the outer regions of M33 [PDF]

, 2011
We present Subaru/Suprime-Cam deep V and I imaging of seven fields in the outer regions of M33. Our aim is to search for stellar structures corresponding to extended HI clouds found in a recent 21-cm survey of the galaxy.
Arimoto, N., Corbelli, E., Giovanardi, C., Grossi, M., Hwang, N., Okamoto, S.   +5 more
core   +1 more source

UBE2T‐Driven p53 Degradation Rewires Glycolysis to Orchestrate Lactylation‐Mediated CAFs Activation and ECM Deposition in Pancreatic Cancer

Advanced Science, EarlyView.
This study integrates multi‐omics to reveal the critical role of UBE2T in driving malignancy and stromal co‐evolution in PDAC. UBE2T potentiates glycolysis by regulating p53 degradation via a positive feedback loop, thereby promoting histone H3 lysine 18 lactylation in CAFs and stromal deposition. The UBE2T inhibitor PGG represents a potential strategy
Yong Ma, Wenbo Liu, Mingdou Li, Tao Wang, Bin Zhao, Keshen Wang, Qichen He, Haonan Sun, Huiguo Qing, Xiaoying Guan, Wengui Shi, Long Qin, Yuman Dong, Huinian Zhou, Zeyuan Yu, Xiangyan Jiang, Zuoyi Jiao   +16 more
wiley   +1 more source

Carbapenem resistance in gram-negative pathogens in an Iranian hospital: high prevalence of OXA-type carbapenemase genes [PDF]

Clinical and Experimental Pediatrics
Background The widespread dissemination of carbapenem-resistant gram-negative bacteria poses a significant threat to global public health. Purpose This study aimed to investigate the prevalence of carbapenem resistance in gram-negative bacteria isolated ...
Setareh Mamishi, Reihaneh Hosseinpour Sadeghi, Sadaf Sajedi Moghaddam, Babak Pourakbari, Shiva Poormohammadi, Maryam Sotoudeh Anvari, Shima Mahmoudi   +6 more
doaj   +1 more source

Rings and Radial Waves in the Disk of the Milky Way

, 2015
We show that in the anticenter region, between Galactic longitudes of $110 ...
Carlin, Jeffrey L., Deng, Licai, Li, Jing, Liu, Chao, Newberg, Heidi Jo, Schönrich, Ralph, Xu, Yan, Yanny, Brian   +7 more
core   +1 more source

The Orbit of the Orphan Stream [PDF]

, 2010
We use recent SEGUE spectroscopy and SDSS and SEGUE imaging data to measure the sky position, distance, and radial velocities of stars in the tidal debris stream that is commonly referred to as the "Orphan Stream." We fit orbital parameters to the data ...
Abazajian, Allende Prieto, An, Belokurov, Belokurov, Belokurov, Belokurov, Benjamin A. Willett, Brian Yanny, Chou, Clem, Combes, Geha, Grillmair, Heidi Jo Newberg, Helmi, Johnston, Jurić, Klypin, Klypin, Koposov, Koposov, Law, Lee, Lee, Majewski, Majewski, Majewski, Miyamoto, Munn, Murali, Newberg, Newberg, Odenkirchen, Schlegel, Teuben, Wilhelm, Willett, Willman, Xue, Yan Xu, Yanny, Yanny, Yanny, Yanny, Zucker   +45 more
core   +1 more source