Results 51 to 60 of about 24,572 (190)

Hypomethylation of GNA15 Promotes Pancreatic Ductal Adenocarcinoma Progression and Macrophage M2 Polarization via STAT3‐CXCL8 Axis

Advanced Science, EarlyView.
A schematic model summarizing GNA15's mechanism in mediating macrophage M2 polarization and Gemcitabine resistance. ABSTRACT The complexity of pancreatic ductal adenocarcinoma (PDAC) progression, coupled with the lack of effective immunotherapy, underscores the imperative to deepen our understanding of its mechanisms and identify suitable immune ...
Weihui Guo, Zhenyuan Qian, Lei Wang, Weilang Xu, Yuxin Weng, Kai Jiang, Zaiyuan Ye, Ji Xu, Guangyuan Song   +8 more
wiley   +1 more source

Production of Carbapenemases in Klebsiella pneumoniae Isolated in Saint-Petersburg [PDF]

Клиническая микробиология и антимикробная химиотерапия, 2016
Carbapenem-resistant nosocomial K. pneumoniae isolates are a significant problem in clinical practice. Carbapenem resistance in K. pneumoniae isolated from hospitalized patients was 2.8% over the study period.
Barantsevich E.P., Barantsevich N.E., Shlyakhto E.V.   +2 more
doaj  

Rapid Multiplex Antimicrobial Resistance Profiling and Bacterial Identification by LAP‐MALDI Mass Spectrometry Biotyping

Advanced Science, EarlyView.
Liquid atmospheric pressure matrix‐assisted laser desorption/ionization (LAP‐MALDI) mass spectrometry (MS) provides multiplexed biotyping of microbial cultures using a fast and simple workflow. This is demonstrated for clinically relevant bacteria, resulting in accurate antimicrobial resistance (AMR) detection, speciation by MS/MS sequencing and ...
Lily R. Adair, Shabnam Iyer, Ian M. Jones, Rainer Cramer   +3 more
wiley   +1 more source

Revisiting Variable Stars Toward the Globular Cluster NGC 6496 With ATLAS and Gaia Photometry

Astronomische Nachrichten, EarlyView.
ABSTRACT We revisit 13 variable stars in the field of the metal‐rich globular cluster NGC 6496, discovered by Abbas et al. (2015; Astronomical Journal 149:40) (hereafter referred to as “MA15”) via time‐series data, spanning 2 years. We improve upon the MA15 characterization of the variables using ATLAS time‐series photometry data, spanning 8 years, in ...
Madison E. Martin, Andrew Layden, Andrew McNeill   +2 more
wiley   +1 more source

Identification of two KPC variants, KPC-204 and KPC-227, in ST11-K64 Klebsiella pneumoniae during prolonged hospitalization of a single patient

Frontiers in Microbiology
IntroductionCarbapenem-resistant Klebsiella pneumoniae (CRKP) represents a critical global public health challenge due to its significant association with morbidity and mortality. Ceftazidime-avibactam (CZA) has emerged as an effective therapy against CRKP producing the serine carbapenemase KPC; however, resistance driven by novel KPC variants is ...
Shijun Sun, Chaoe Zhou, Haijun Li, Liying Sun, Saiqi Qi, Xinmin Liu, Wanhai Wang   +6 more
openaire   +3 more sources

Oseltamivir drug‐disease modelling in infants with influenza virus infection

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Oseltamivir is a commonly used neuraminidase inhibitor for treatment of influenza infection, but little data exist regarding concentration‐response relationships. Methods Pharmacokinetic (PK) and viral dynamic data from an earlier NIAID Collaborative Antiviral Study Group trial in paediatric patients with influenza from 0–23 months of age
Kun Wang, David W. Kimberlin, Richard J. Whitley, Edward P. Acosta, For the National Institute of Allergy and Infectious Diseases Collaborative Antiviral Study Group   +4 more
wiley   +1 more source

Women Empowerment in India – A Perspective

National Journal of Community Medicine, 2018
Background: The study presents an index of women empower- ment based on a statistical technique of data reduction viz. factor analysis and provides an in depth analysis of states in India with respect to the National Family Health Survey-4 (NFHS-4 ...
Ankita Dey, Kunal K Majumdar, Arun Kumar Chakraborty, Asok Kumar Mandal   +3 more
doaj  

Landslide Emergency Response Preparedness in Mining Areas: Early Warning System Implementation

The Indonesian Journal of Occupational Safety and Health
Introduction: Coal mining operations present serious risks due to landslip risks, necessitating the use of efficient early warning systems and emergency preparation. This paper examines the use of an early warning system called LASER (Land Sliding Alert)
Ardhila Chadarisman, Tedi Cahya Nusantara Herdianto   +1 more
doaj   +1 more source

Hypoparathyroidism in a Case of Transfusion Dependent Thalassemia

Journal of the ASEAN Federation of Endocrine Societies, 2020
Repeated blood transfusions in transfusion dependent thalassemia (TDT) leads to iron overload-related endocrine complications. Hypoparathyroidism (HPT) with severe signs of hypocalcemia is a recognized complication among these patients. A 14-year-old
Anirban Majumder, Sagar Basu
doaj   +1 more source

Stereoretentive Nucleophilic Aromatic Substitution Accesses Atropisomeric 4‐Amino‐N‐Arylquinolinium Salts

Chemistry – A European Journal, EarlyView.
Quinolin‐4‐ones were converted to chloroquinolinium salts, allowing formation of axially chiral aminoquinolinium salts via an enantioretentive SNAr reaction with a variety of amine nucleophiles. The salts have a high rotational barrier, with a racemization half‐life of ∼1000s of years.
Darren Holmes, Nia Foster, Saima Ansari, Paul Kavanagh, Paul Dingwall, Peter C. Knipe   +5 more
wiley   +1 more source