Results 51 to 60 of about 161,113 (157)

β‐Adrenergic Signaling Promotes Anti‐Tumor Immunity in TP53‐mutant Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
β‐adrenergic stimulation enhances anti‐tumor immunity in TP53‐deficient oral squamous cell carcinoma by inducing tumor‐derived secretion of CXCL10, which attracts and activates cytotoxic CD8+ T cells. The findings demonstrate that β‐adrenergic signaling alters tumor–immune interactions via CXCL10‐mediated paracrine activation, revealing a neuro‐immune ...
Frederico O. Gleber‐Netto, Deborah Silverman, Tongxin Xie, Shamima Akhter, Nicole R. Vaughn, Adewale Adebayo, Kala Chand Debnath, Shorook Naara, Shajedul Islam, Erik Knutsen, Emily Lorin Ashkin, Simone Anfossi, Sara Leahey, Patrick Hwu, Sebastien Talbot, Erica K Sloan, Robert Saddawi‐Konefka, Roberto Rangel, Jeffrey N. Myers, George A. Calin, Moran Amit   +20 more
wiley   +1 more source

Phenotypic and Genetic Analysis of KPC-49, a KPC-2 Variant Conferring Resistance to Ceftazidime–Avibactam and Maintaining Resistance to Imipenem and Meropenem

Infection and Drug Resistance, 2023
Meng Yu, Qingzheng Wei, Weiqing Song, Jiangshui Yuan Clinical Laboratory, University of Health and Rehabilitation Sciences (Qingdao Municipal Hospital), Qingdao, Shandong, People’s Republic of ChinaCorrespondence: Jiangshui Yuan; Weiqing Song, Clinical ...
Yu M, Wei Q, Song W, Yuan J
doaj  

DOTA‐grafted Cationic Polymers Behaving as Powerful Macromolecular Resistance‐reversal Agents (MRRAs) Combating Against New Delhi Metallo‐β‐lactamase (NDM)‐producing Bacteria

Advanced Science, EarlyView.
Two macromolecular resistance‐reversal agents (MRRAs)—linear (MRRAL) and nanostructured (MRRAN) polymers were fabricated by integrating DOTA motifs into tunable polycationic scaffolds. MRRAs exhibit superior antibacterial potency once combined with meropenem (MEM) through (i) bacterial membrane disruption via localized cationic charge and ...
Ruixue Wang, Jian Zhang, Yun li, Liping Qiao, Zhuorui Dong, Dandan Cui, Peirong Bai, Liping Li, Bing Cao, Ruiping Zhang   +9 more
wiley   +1 more source

Production of Carbapenemases in Klebsiella pneumoniae Isolated in Saint-Petersburg [PDF]

Клиническая микробиология и антимикробная химиотерапия, 2016
Carbapenem-resistant nosocomial K. pneumoniae isolates are a significant problem in clinical practice. Carbapenem resistance in K. pneumoniae isolated from hospitalized patients was 2.8% over the study period.
Barantsevich E.P., Barantsevich N.E., Shlyakhto E.V.   +2 more
doaj  

Hypoparathyroidism in a Case of Transfusion Dependent Thalassemia

Journal of the ASEAN Federation of Endocrine Societies, 2020
Repeated blood transfusions in transfusion dependent thalassemia (TDT) leads to iron overload-related endocrine complications. Hypoparathyroidism (HPT) with severe signs of hypocalcemia is a recognized complication among these patients. A 14-year-old
Anirban Majumder, Sagar Basu
doaj   +1 more source

Endocrine Therapy of Adult Gender-Incongruent Individuals Seeking Gender Reaffirmation

Indian Journal of Plastic Surgery, 2022
Gender-affirming hormone therapy (GAHT) is integral to the management of gender-incongruent (GI) individuals. GAHT greatly improves the quality of life for GI individuals.
Anirban Majumder
doaj   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Women Empowerment in India – A Perspective

National Journal of Community Medicine, 2018
Background: The study presents an index of women empower- ment based on a statistical technique of data reduction viz. factor analysis and provides an in depth analysis of states in India with respect to the National Family Health Survey-4 (NFHS-4 ...
Ankita Dey, Kunal K Majumdar, Arun Kumar Chakraborty, Asok Kumar Mandal   +3 more
doaj  

Identification and Characterization of Carbapenem Hydrolysing β-lactamase – KPC among Enterobacteriaceae: A report from North India

Asian Journal of Medical Sciences, 2013
Objective: The serine carbapenemase KPC (Klebsiella pneumoniae carbapenemase) has emerged as a beta-lactamase capable of inactivating carbapenem antibiotics.
Supriya Upadhyay
doaj   +1 more source

Galactic Parameters from Masers with Trigonometric Parallaxes

, 2010
Spatial velocities of all currently known 28 masers having trigonometric parallaxes, proper motion and line-of-site velocities are reanalyzed using Bottlinger's equations. These masers are associated with 25 active star-forming regions and are located in
Anisa T. Bajkova, Asaki, Aumer, Avedisova, Baba, Bobylev, Bobylev, Bovy, Bower, Burton, Byl, Clemens, Dehnen, Famaey, Fernández, Francis, Ghez, Gillessen, Hirota, Hirota, Hirota, Kharchenko, Lin, Lépine, McMillan, Mel'nik, Mishurov, Mishurov, Ogorodnikov, Piskunov, Reid, Rohlfs, Russeil, Rygl, Sandstrom, Sato, Sato, Schönrich, Vadim V. Bobylev, Van Leeuwen, Vityazev, Zabolotskikh   +41 more
core   +1 more source