Krüppel-like factor 4 regulates intestinal epithelial cell morphology and polarity. [PDF]
PLoS ONE, 2012 Krüppel-like factor 4 (KLF4) is a zinc finger transcription factor that plays a vital role in regulating cell lineage differentiation during development and maintaining epithelial homeostasis in the intestine.
Tianxin Yu +7 more
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Elevated Krüppel-like factor 4 transcription factor in canine mammary carcinoma [PDF]
BMC Veterinary Research, 2011 Background Krüppel-like factors (KLFs) are critical regulators of biological and physiological systems and have been extensively studied for their roles in cell proliferation, differentiation and survival in the context of cancer. Among the KLFs, KLF4 is
Yeh Kun-Tu +5 more
doaj +5 more sources
Inhibition of miR-25 Ameliorates Cardiac Dysfunction and Fibrosis by Restoring Krüppel-like Factor 4 Expression. [PDF]
Int J Mol Sci, 2023 Lee C, Cho S, Jeong D.
europepmc +3 more sources
Transcription factors Krüppel-like factor 4 and paired box 5 regulate the expression of the Grainyhead-like genes. [PDF]
PLoS ONE, 2021 Genes from the Grainyhead-like (GRHL) family code for transcription factors necessary for the development and maintenance of various epithelia. These genes are also very important in the development of many types of cancer. However, little is known about
Grzegorz Kotarba +4 more
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Therapeutic targeting of Krüppel-like factor 4 abrogates microglial activation [PDF]
Journal of Neuroinflammation, 2012 Background Neuroinflammation occurs as a result of microglial activation in response to invading micro-organisms or other inflammatory stimuli within the central nervous system.
Kaushik Deepak +4 more
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Hypoxia‐inducible factor‐1α attenuates renal podocyte injury in male rats in a simulated high‐altitude environment by upregulating Krüppel‐like factor 4 expression [PDF]
Experimental PhysiologyPrevious studies have shown that podocyte injury is involved in the development of proteinuria in rats under hypobaric hypoxia conditions. Prolyl hydroxylase inhibitors (PHIs) may reduce proteinuria.
Zeng Xiaoshan +5 more
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Mesenchymal Mycn participates in odontoblastic lineage commitment by regulating Krüppel-like Factor 4 (Klf4) in mice [PDF]
Stem Cell Research & Therapy, 2022 Background Commitment of mouse dental papilla cells (mDPCs) to the odontoblast lineage is critical for dentin formation, and this biological process is regulated by a complex transcription factor network. The transcription factor Mycn is a proto-oncogene
Zhuo Huang +6 more
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Transcription factor Krüppel‐like factor 4 upregulated G protein‐coupled receptor 30 alleviates intestinal inflammation and apoptosis, and protects intestinal integrity from intestinal ischemia–reperfusion injury [PDF]
Immunity, Inflammation and Disease, 2023 Introduction Intestinal ischemia/reperfusion (I/R) injury is a common clinical event occurring during multiple clinical pathological processes. Here, we designed this paper to discuss the role of G protein‐coupled receptor 30 (GPR30) playing in ...
Jie Yin +5 more
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Extracellular vesicles from 3D cultured dermal papilla cells improve wound healing via Krüppel-like factor 4/vascular endothelial growth factor A -driven angiogenesis. [PDF]
Burns Trauma, 2023 Wang Y +17 more
europepmc +3 more sources
Krüppel-like factor 4 promotes survival and expansion in acute myeloid leukemia cells. [PDF]
Oncotarget, 2021 Lewis AH +5 more
europepmc +3 more sources