Results 61 to 70 of about 2,366 (190)
Supernatants derived from chemotherapy-treated cancer cell lines can modify angiogenesis [PDF]
, 2012 BACKGROUND: There is evidence that tumours produce substances such as cytokines and microvesicular bodies bearing bioactive molecules, which support the carcinogenic process.
Bodman-Smith, M +8 more
core +1 more source
Mechanism for KRIT1 Release of ICAP1-Mediated Suppression of Integrin Activation [PDF]
Molecular Cell, 2013 KRIT1 (Krev/Rap1 Interaction Trapped-1) mutations are observed in ∼40% of autosomal-dominant cerebral cavernous malformations (CCMs), a disease occurring in up to 0.5% of the population. We show that KRIT1 functions as a switch for β1 integrin activation by antagonizing ICAP1 (Integrin Cytoplasmic Associated Protein-1)-mediated modulation of "inside ...
Liu, Weizhi +4 more
openaire +2 more sources
Upregulation of transmembrane endothelial junction proteins in human cerebral cavernous malformations [PDF]
, 2010 OBJECT: Cerebral cavernous malformations (CCMs) are among the most prevalent cerebrovascular malformations, and endothelial cells seem to play a major role in the disease.
Chappell PM +8 more
core +1 more source
Zebrafish models of cerebrovascular disease [PDF]
, 2014 Perturbations in cerebral blood flow and abnormalities in blood vessel structure are the hallmarks of cerebrovascular disease. While there are many genetic and environmental factors that affect these entities through a heterogeneous group of disease ...
Peterson, Randall T, Walcott, Brian P
core +1 more source
American Journal of Medical Genetics Part A, Volume 197, Issue 11, November 2025.ABSTRACT Some vascular anomalies, such as hamartomas associated with PTEN hamartoma tumor syndrome (PHTS) and fibroadipose vascular anomaly (FAVA, often due to PI3KCA variants), share similar clinical, radiological, and histopathological presentations that challenge clinicians to provide an accurate diagnosis.
Luciana Daniela Garlisi Torales +10 more
wiley +1 more source
Nieuw rechts en de verzorgingsstaat [PDF]
, 2013 Volgens veel wetenschappers onderscheiden nieuw-rechtse populistische partijen zich van andere partijen door hun nadruk op een autoritaire culturele agenda. Als zelfverklaarde verdedigers van de belangen van de autochtone ‘gewone man’ nemen nieuw-rechtse
Achterberg, P.H.J. (Peter) +2 more
core +1 more source
Plasma Proteomic Profiling of a Group of Anxious Dogs by LC‐MS/MS: A Case–Control Study
PROTEOMICS – Clinical Applications, Volume 19, Issue 4, July 2025.ABSTRACT Purpose Anxiety is the most common underlying cause of behavioral problems in dogs, which remain a top reason for relinquishment and euthanasia. Despite its high prevalence, anxiety is often underdiagnosed, partly due to a limited understanding of biological processes and absence of diagnostic biomarkers.
Claudia Gaither +4 more
wiley +1 more source
Cardiovascular Diabetology, 2018 Background Antioxidant enzymes play a fundamental role in counteracting oxidative stress induced by high glucose. Although mitochondrial superoxide dismutase (SOD2) is the principal defence against the toxicity of superoxide anions, the mechanism of its ...
Lucia La Sala +4 more
doaj +1 more source
Krit1 inhibited proliferation and metastasis of human colon cancer via DPPIV signaling pathway [PDF]
, 2010 Oral presentationpublished_or_final_versionThe 15th Annual Research Conference of the Department of Medicine, The University of Hong Kong, Hong Kong, 16 January 2010. In Hong Kong Medical Journal, 2010, v. 16, suppl. 1, p.
Hung, IFN +7 more
core
Adding to Your Tool Box: Laser Therapy for Vascular Anomalies
Pediatric Dermatology, Volume 42, Issue 4, Page 716-727, July/August 2025.ABSTRACT Adjuvant laser therapy of vascular anomalies is based on the principle of selective photo‐thermolysis, through targeted destruction of selected chromophores with minimal injury to surrounding tissue. Choice of laser wavelength, treatment parameters, and predicted response to therapy are dependent on the dominant chromophore within the vascular
Kevin V. Thomas +8 more
wiley +1 more source