Krüppel-like transcription factors KLF1 and KLF2 have unique and coordinate roles in regulating embryonic erythroid precursor maturation [PDF]
Haematologica, 2014 The Krüppel-like transcription factors KLF1 and KLF2 are essential for embryonic erythropoiesis. They can partially compensate for each other during mouse development, and coordinately regulate numerous erythroid genes, including the β-like globins ...
Divya S. Vinjamur +5 more
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Krüppel-like transcription factors and control of pluripotency [PDF]
BMC Biology, 2010 Recent papers have demonstrated a role for Krüppel-like transcription factors 2, 4 and 5 in the control of mouse embryonic stem cell pluripotency. However, it is not clear whether each factor has a unique role or whether they are functionally redundant ...
Bourillot Pierre-Yves, Savatier Pierre
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Activation and Repression of Interleukin-12 p40 Transcription by Erythroid Kruppel-like Factor in Macrophages [PDF]
Journal of Biological Chemistry, 2004 Transcription of interleukin (IL)-12 p40 in myeloid cells is attributed to the recruitment of multiple activated transcription factors such as nuclear factor kappaB (NFkappaB), CCAAT enhancer-binding protein beta, ets-2, PU.1, and so forth. We now provide the first description of the human erythroid Kruppel-like factor (EKLF) in human primary ...
Qi Luo +5 more
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Kruppel-Like Factor 2 Is a Transcriptional Regulator of Chronic and Acute Inflammation [PDF]
The American Journal of Pathology, 2013 Although myeloid cell activation is requisite for an optimal innate immune response, this process must be tightly controlled to prevent collateral host tissue damage. Kruppel-like factor 2 (KLF2) is a potent regulator of myeloid cell proinflammatory activation.
Lalitha Nayak +6 more
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The thromboprotective effect of bortezomib is dependent on the transcription factor Kruppel-like factor 2 (KLF2) [PDF]
Blood, 2014 Key Points Transcription factor KLF2 is a critical determinant of vascular thrombosis. The antithrombotic effect noted with bortezomib is KLF2 dependent.
Lalitha Nayak +5 more
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Cell-specific Transcription of Leukotriene C4Synthase Involves a Kruppel-like Transcription Factor and Sp1 [PDF]
Journal of Biological Chemistry, 2000 Leukotriene C(4) synthase (LTC(4)S) is responsible for the biosynthesis of cysteinyl leukotrienes that participate in allergic and asthmatic inflammation. We analyzed 2.1 kilobases of the 5'-flanking region of the human LTC(4)S gene, which contains three DNase I hypersensitivity sites, for its transcriptional activity when fused to a promoterless and ...
Ji-liang Zhao, K. Frank Austen, Bing Lam
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Transcriptional repression of Kruppel like factor‐2 by the adaptor protein p66shc
The FASEB Journal, 2009 ABSTRACT The adaptor protein p66shc promotes cellular oxidative stress and apoptosis. Here, we demonstrate a novel mechanistic relationship between p66shc and the kruppel like factor‐2 (KLF2) transcription factor and show that this relationship has biological relevance to p66shc‐regulated cellular oxidant level ...
Ajay Kumar +5 more
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Cutting Edge: The Transcription Factor Kruppel-Like Factor 4 Regulates the Differentiation of Th17 Cells Independently of RORγt [PDF]
The Journal of Immunology, 2010 Abstract Th17 cells play a significant role in inflammatory and autoimmune responses. Although a number of molecular pathways that contribute to the lineage differentiation of T cells have been discovered, the mechanisms by which lineage commitment occurs are not fully understood.
Lori Lebson +6 more
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Abnormal expression of Krüppel-like transcription factors and their potential values in lung cancer [PDF]
HeliyonLung cancer still is one of the most common malignancy tumors in the world. However, the mechanisms of its occurrence and development have not been fully elucidated.
Yang Shi +4 more
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GATA Binding Protein 3 Is a Direct Target of Kruppel-Like Transcription Factor 7 and Inhibits Chicken Adipogenesis [PDF]
Frontiers in Physiology, 2020 Kruppel-like transcription factor 7 (KLF7) is a negative regulator of adipogenesis, however, its precise mechanism is poorly understood. Our previous KLF7 ChIP-seq analysis showed that one of the KLF7 binding peaks was present upstream of GATA binding protein 3 (GATA3) in chicken preadipocytes.
Yingning Sun +7 more
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