Results 141 to 150 of about 193,609 (276)
Kruppel-like factor 4 regulates neutrophil activation
Blood Advances, 2017 : Neutrophils are the most abundant white blood cells in circulation and are key components of the innate immune response. Clinical and experimental studies support an important role for the neutrophils in a broad spectrum of acute and chronic ...
Yuyan Shen +7 more
doaj
Double the Double: Revisiting BCL11B's Multimerization
Proteins: Structure, Function, and Bioinformatics, Volume 93, Issue 7, Page 1205-1211, July 2025.ABSTRACT The transcription factor B Cell Lymphoma/Leukemia 11B (BCL11B) exerts a bi‐directional function in cancer, with its role as an emerging therapeutic target in cancer treatment being particularly intriguing. BCL11B knockouts in cultured T cells revealed the acquisition of properties characteristic of natural killer cells, hinting at its ...
Anne Susemihl +5 more
wiley +1 more source
Transcriptional profiling of fetal hypothalamic TRH neurons [PDF]
, 2011 RIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/about/license which is similar to the 'Creative Commons Attribution Licence'.
Castillo-Ramirez, Santiago +7 more
core +4 more sources
The FASEB Journal, Volume 39, Issue 11, 15 June 2025.NaVβ3 expression is increased by laminar shear stress (LSS) through KLF4 induction (1). NaVβ3 is retained within the cell and interacts with mTOR protein and colocalizes partially with LAMP1 and LC3B, lysosome and autophagosome markers, respectively (2). Since SiRNA SCN3B induces the decrease of LC3B expression and cell alignment in response to LSS (3),
Léa Réthoré +13 more
wiley +1 more source
Aberrant regulation of FBW7 in cancer [PDF]
, 2014 FBW7 (F-box and WD repeat domain-containing 7) or Fbxw7 is a tumor suppressor, which promotes the ubiquitination and subsequent degradation of numerous oncoproteins including Mcl-1, Cyclin E, Notch, c- Jun, and c-Myc.
Liu, Yueyong +4 more
core +1 more source
Advanced Science, Volume 12, Issue 21, June 5, 2025.In KLF1‐on (neonatal and Klf1 overexpression hearts) models, KLF1 regulates Wnt/β‐catenin signaling pathway and the expression of cell proliferation‐related genes via transcriptional and epigenetic mechanisms, which induces cardiomyocyte proliferation and cardiac regeneration in mice after myocardial infarction.
Yanglin Hao +19 more
wiley +1 more source
Acetylation-dependent regulation of essential iPS-inducing factors: a regulatory crossroad for pluripotency and tumorigenesis [PDF]
, 2015 Induced pluripotent stem (iPS) cells can be generated from somatic cells by coexpression of four transcription factors: Sox2, Oct4, Klf4, and c-Myc.
Dai, Xiangpeng +4 more
core +1 more source
Negative Example Aided Transcription Factor Binding Site Search [PDF]
arXiv, 2011 Computational approaches to transcription factor binding site identification have been actively researched for the past decade. Negative examples have long been utilized in de novo motif discovery and have been shown useful in transcription factor binding site search as well.
arxiv
Immunology, Volume 175, Issue 2, Page 123-133, June 2025.The tumour microenvironment (TME) and tumour evolution stage lead to temporal and spatial heterogeneity in tumour‐resident macrophages (TRMs), affecting their phenotype and function across different stages and tumour types. While TRMs infiltration is often linked to positive immunotherapy responses and prognosis, some subtypes may negatively impact ...
Yile Shang +10 more
wiley +1 more source
Characterization of Carotid Smooth Muscle Cells during Phenotypic Transition [PDF]
, 2018 Vascular smooth muscle cells (VSMCs) are central players in carotid atherosclerosis plaque development. Although the precise mechanisms involved in plaque destabilization are not completely understood, it is known that VSMC proliferation and migration ...
Alloza Moral, Iraide +7 more
core +3 more sources