Results 141 to 150 of about 33,501 (214)

Peripheral Nerves in Cancer: Regulatory Roles and Therapeutic Strategies

MedComm, Volume 7, Issue 2, February 2026.
The interaction between cancer cells and peripheral nerves: (1) tumor cells could induce the growth of new neural axons and constructing a neural fiber network within the tumor tissue through secreting nerve growth factors; (2) nerve‐derived bioactive molecules can induce perineural invasion of tumor and regulate the malignant phenotype of tumor, such ...
Yan Fu, Zhi‐Shan Ge, Qing‐Yue Cao, Zi‐Han Li, An Zhang, Hai‐Dong Zhu, Gao‐Jun Teng   +6 more
wiley   +1 more source

Kruppel-like factor 4 regulates neutrophil activation

Blood Advances, 2017
: Neutrophils are the most abundant white blood cells in circulation and are key components of the innate immune response. Clinical and experimental studies support an important role for the neutrophils in a broad spectrum of acute and chronic ...
Yuyan Shen, Hong Hong, Panjamaporn Sangwung, Stephanie Lapping, Lalitha Nayak, Lilei Zhang, Mukesh K. Jain, Xudong Liao   +7 more
doaj   +1 more source

Genome-wide ChIP-Seq reveals a dramatic shift in the binding of the transcription factor erythroid Kruppel-like factor during erythrocyte differentiation

Blood, 2011
Abstract Erythropoiesis is dependent on the activity of transcription factors, including the erythroid-specific erythroid Kruppel-like factor (EKLF). ChIP followed by massively parallel sequencing (ChIP-Seq) is a powerful, unbiased method to map trans-factor occupancy.
Andre M, Pilon, Subramanian S, Ajay, Swathi Ashok, Kumar, Laurie A, Steiner, Praveen F, Cherukuri, Stephen, Wincovitch, Stacie M, Anderson, James C, Mullikin, Patrick G, Gallagher, Ross C, Hardison, Elliott H, Margulies, David M, Bodine   +11 more
openaire   +3 more sources

Challenge Specific Modulation of Responses to Adjuvant‐Induced Innate Immune Memory

Immunology, Volume 177, Issue 2, Page 254-269, February 2026.
We utilised a commercially available adjuvant formulation to study the induction, maintenance, and consequences of innate immune memory. Using functional assays on bone marrow‐derived innate cells, extensive transcriptomic analysis of haematopoietic progenitors, and challenge models of spirochetal infection, nonspecific inflammation, and model antigen ...
Samuel T. Pasco, Itziar Martín‐Ruiz, Sarai Araujo‐Aris, Diego Barriales, Janire Castelo, Leire Egia‐Mendikute, Monika Gonzalez, Jose Ezequiel Martin, Elena Molina, Maitane Mugica, Ainhoa Palacios, Iratxe Seoane, Naiara Gutiez, Estibaliz Atondo, Eneko Santos Fernández, Maddi Oyanguren, Borja Jimenez‐Lasheras, Ainize Peña‐Cearra, Ana M. Aransay, Asis Palazon, Aize Pellón, Leticia Abecia, Hector Rodriguez, Natalia Elguezabal, Juan Anguita   +24 more
wiley   +1 more source

KLF feedback loops in innate immunity

Frontiers in Immunology
The Krüppel-like factor (KLF) family of zinc finger transcription factors regulate the expression of genes involved in a wide range of cellular processes, including cell proliferation and differentiation.
Jessica M. Salmon, Holly Adams, Graham W. Magor, Andrew C. Perkins   +3 more
doaj   +1 more source

Direct competition between DNA binding factors highlights the role of Krüppel-like Factor 1 in the erythroid/megakaryocyte switch

Scientific Reports, 2017
The Krüppel-like factor (KLF) family of transcription factors play critical roles in haematopoiesis. KLF1, the founding member of the family, has been implicated in the control of both erythropoiesis and megakaryopoiesis.
Laura J. Norton, Samantha Hallal, Elizabeth S. Stout, Alister P. W. Funnell, Richard C. M. Pearson, Merlin Crossley, Kate G. R. Quinlan   +6 more
doaj   +1 more source

Bioinformatics analysis of the early inflammatory response in a rat thermal injury model

BMC Bioinformatics, 2007
Background Thermal injury is among the most severe forms of trauma and its effects are both local and systemic. Response to thermal injury includes cellular protection mechanisms, inflammation, hypermetabolism, prolonged catabolism, organ dysfunction and
Berthiaume Francois, Yarmush Martin L, Maguire Timothy, Yang Eric, Androulakis Ioannis P   +4 more
doaj   +1 more source

The hardwiring of development: Organization and function of genomic regulatory systems [PDF]

, 1997
The gene regulatory apparatus that directs development is encoded in the DNA, in the form of organized arrays of transcription factor target sites. Genes are regulated by interactions with multiple transcription factors and the target sites for the ...
Arnone, Maria I., Davidson, Eric H.
core  

KLF1 Exerts Pro‐Tumour Role in Liver Cancer via Inhibiting ACSL4/LPCAT3‐Regulated Ferroptosis

Journal of Cellular and Molecular Medicine, Volume 30, Issue 3, February 2026.
ABSTRACT Kruppel‐like factors (KLFs) constitute a crucial family of transcription factors that are engaged in a variety of biological processes, such as erythropoiesis as well as liver development. A growing body of research underscores the increasing importance of the KLF family in the context of hepatocellular carcinoma (HCC). Despite this, the exact
Zhihui Chen, Changyan Zhang, Jialin Yang, Yong Peng   +3 more
wiley   +1 more source

AAV‐Driven miR‐146a Promotes Neurite Outgrowth and Axonal Regeneration in Cortical Neurons

Journal of Neurochemistry, Volume 170, Issue 2, February 2026.
In the adult central nervous system (CNS), neuronal regeneration after injury is limited, resulting in poor functional recovery. MicroRNAs (miRNAs), a class of small noncoding RNAs that control gene expression, have gained attention as potential therapeutic agents, although their contribution to CNS repair remains insufficiently understood.
V. U. S. Matos, R. A. Almeida, C. G. Ferreira, M. T. R. Alves, M. P. Braga, M. C. Silva, T. F. da Silva, P. P. G. Guimarães, F. M. Soriani, P. Caramelli, M. R. Costa, U. Michel, V. T. Ribas   +12 more
wiley   +1 more source