Krüppel-like transcription factors and control of pluripotency [PDF]
Recent papers have demonstrated a role for Krüppel-like transcription factors 2, 4 and 5 in the control of mouse embryonic stem cell pluripotency. However, it is not clear whether each factor has a unique role or whether they are functionally redundant ...
Bourillot Pierre-Yves, Savatier Pierre
doaj +2 more sources
Abnormal expression of Krüppel-like transcription factors and their potential values in lung cancer [PDF]
Lung cancer still is one of the most common malignancy tumors in the world. However, the mechanisms of its occurrence and development have not been fully elucidated.
Yang Shi +4 more
doaj +2 more sources
Krüppel-like transcription factors KLF1 and KLF2 have unique and coordinate roles in regulating embryonic erythroid precursor maturation [PDF]
The Krüppel-like transcription factors KLF1 and KLF2 are essential for embryonic erythropoiesis. They can partially compensate for each other during mouse development, and coordinately regulate numerous erythroid genes, including the β-like globins ...
Divya S. Vinjamur +5 more
doaj +2 more sources
Krüppel-like factor 4 control of immune cell function [PDF]
Krüppel-like factor 4 (KLF4) belongs to a family of transcription factors that contain conserved zinc finger DNA binding domains, including specificity proteins (SPs) and Krüppel-like factors (KLFs).
Tapatee Das +6 more
doaj +2 more sources
KLF7 is a general inducer of human pluripotency [PDF]
Pluripotency is the capacity to generate all somatic cells and the germ line and is governed by a self-reinforcing network of transcription factors.
Mattia Arboit +11 more
doaj +2 more sources
Abstract Antiphospholipid syndrome is characterized by thrombosis and/or recurrent pregnancy loss in the presence of antiphospholipid antibodies (APLAs). The majority of APLAs are directed against phospholipid-binding proteins, particularly β2-glycoprotein I (β2GPI).
Allen KL, Hamik A, Jain MK, McCrae KR.
europepmc +4 more sources
Krüppel-like factors in mitochondrial quality control [PDF]
Krüppel-like factors (KLFs) are a group of transcription factors characterized by conserved zinc finger domains in the C-terminus, which are critically involved in basic cellular processes, including growth, differentiation, apoptosis, and angiogenesis ...
M. Y. Zhang +3 more
doaj +2 more sources
Molecular basis for modulation of the p53 target selectivity by KLF4 [PDF]
The tumour suppressor p53 controls transcription of various genes involved in apoptosis, cell-cycle arrest, DNA repair and metabolism. However, its DNA-recognition specificity is not nearly sufficient to explain binding to specific locations in vivo ...
Brandt, Tobias +4 more
core +16 more sources
Kruppel-like Transcription Factor 6 Regulates Inflammatory Macrophage Polarization [PDF]
Accumulating evidence supports the importance of macrophage plasticity in a broad spectrum of biological processes operative in health and disease. A major locus of control regulating macrophage polarization is at the transcriptional level, and several major pathways have been elucidated in recent years.
Dipali, Date +5 more
openaire +2 more sources
Suppression of glioblastoma tumorigenicity by the Kruppel-like transcription factor KLF6 [PDF]
The Kruppel-like transcription factor KLF6 is a novel tumor-suppressor gene mutated in a significant fraction of human prostate cancer. It is localized to human chromosome 10p14-15, a region that displays frequent loss of heterozygosity in glioblastoma multiforme (GBM).
Alec C, Kimmelman +11 more
openaire +2 more sources

