Molecular basis for modulation of the p53 target selectivity by KLF4 [PDF]
PLoS ONE, 2012 The tumour suppressor p53 controls transcription of various genes involved in apoptosis, cell-cycle arrest, DNA repair and metabolism. However, its DNA-recognition specificity is not nearly sufficient to explain binding to specific locations in vivo ...
Brandt, Tobias +4 more
core +21 more sources
Lung Kruppel-like Factor, a Zinc Finger Transcription Factor, Is Essential for Normal Lung Development [PDF]
Journal of Biological Chemistry, 1999 Lung Kruppel-like factor (LKLF) is a member of the Kruppel-like factor family of transcription factors and is highly expressed in lung with limited distribution in other tissues. Mice lacking LKLF due to inactivation of LKLF by gene targeting die in utero at midgestation around day 12.5 due to severe hemorrhage, making it difficult to study the role of
Maqsood A. Wani +2 more
openaire +5 more sources
Cell-specific Transcription of Leukotriene C4Synthase Involves a Kruppel-like Transcription Factor and Sp1 [PDF]
Journal of Biological Chemistry, 2000 Leukotriene C(4) synthase (LTC(4)S) is responsible for the biosynthesis of cysteinyl leukotrienes that participate in allergic and asthmatic inflammation. We analyzed 2.1 kilobases of the 5'-flanking region of the human LTC(4)S gene, which contains three DNase I hypersensitivity sites, for its transcriptional activity when fused to a promoterless and ...
Bing K. Lam +2 more
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Kruppel-like Transcription Factor 6 Regulates Inflammatory Macrophage Polarization [PDF]
Journal of Biological Chemistry, 2014 Accumulating evidence supports the importance of macrophage plasticity in a broad spectrum of biological processes operative in health and disease. A major locus of control regulating macrophage polarization is at the transcriptional level, and several major pathways have been elucidated in recent years.
Goutham Narla +5 more
openaire +5 more sources
Suppression of glioblastoma tumorigenicity by the Kruppel-like transcription factor KLF6 [PDF]
Oncogene, 2004 The Kruppel-like transcription factor KLF6 is a novel tumor-suppressor gene mutated in a significant fraction of human prostate cancer. It is localized to human chromosome 10p14-15, a region that displays frequent loss of heterozygosity in glioblastoma multiforme (GBM).
Abhijit Guha +11 more
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Transcriptional repression of Kruppel like factor‐2 by the adaptor protein p66shc
The FASEB Journal, 2009 The adaptor protein p66shc promotes cellular oxidative stress and apoptosis. Here, we demonstrate a novel mechanistic relationship between p66shc and the kruppel like factor-2 (KLF2) transcription factor and show that this relationship has biological relevance to p66shc-regulated cellular oxidant level, as well as KLF2-induced target gene expression ...
Ajay Kumar +5 more
openaire +6 more sources
Transcriptional repression of the tyrosinase-related protein 2 gene by transforming growth factor-β and the Kruppel-like transcription factor GLI2 [PDF]
Journal of Dermatological Science, 2019 Tyrosinase-Related Protein 2 (TRP2) is an enzyme involved in melanogenesis, that also exerts proliferative, anti-apoptotic and immunogenic functions in melanoma cells. TRP2 transcription is regulated by the melanocytic master transcription factor MITF.
Véronique Marsaud +5 more
openaire +6 more sources
New Role for Kruppel-like Factor 14 as a Transcriptional Activator Involved in the Generation of Signaling Lipids [PDF]
Journal of Biological Chemistry, 2014 Sphingosine kinase 1 (SK1) is an FGF-inducible gene responsible for generation of sphingosine-1-phosphate, a critical lipid signaling molecule implicated in diverse endothelial cell functions. In this study, we identified SK1 as a target of the canonical FGF2/FGF receptor 1 activation pathway in endothelial cells and sought to identify novel ...
Thiago M. De Assuncao +8 more
openaire +5 more sources
Kruppel-Like Factor 2 Is a Transcriptional Regulator of Chronic and Acute Inflammation
The American Journal of Pathology, 2013 Although myeloid cell activation is requisite for an optimal innate immune response, this process must be tightly controlled to prevent collateral host tissue damage. Kruppel-like factor 2 (KLF2) is a potent regulator of myeloid cell proinflammatory activation.
Nikunj Sharma +6 more
openaire +4 more sources
The Kruppel-like transcription factor KLF13 is a novel regulator of heart development [PDF]
The EMBO Journal, 2006 In humans, congenital heart defects occur in 1-2% of live birth, but the molecular mechanisms and causative genes remain unidentified in the majority of cases. We have uncovered a novel transcription pathway important for heart morphogenesis. We report that KLF13, a member of the Krüppel-like family of zinc-finger proteins, is expressed predominantly ...
Nemer, Georges +6 more
openaire +6 more sources