Results 11 to 20 of about 33,472 (185)

Krüppel-like factor 4 transcriptionally regulates TGF-β1 and contributes to cardiac myofibroblast differentiation. [PDF]

PLoS ONE, 2013
Angiotensin II (Ang II) plays a major role in the pathogenesis of cardiac fibrosis in hypertension. It is known that Ang II induces TGF-β1 expression.
Yi Zhang, Ying Wang, Yan Liu, Nanping Wang, Yongfen Qi, Jie Du   +5 more
doaj   +1 more source

Krüppel-like factor 2: a central regulator of B cell differentiation and plasma cell homing

Frontiers in Immunology, 2023
The development of B cells, their activation and terminal differentiation into antibody-producing plasma cells are characterized by alternating phases of proliferation and quiescence that are controlled by complex transcriptional networks.
Jens Wittner, Wolfgang Schuh
doaj   +1 more source

Transcription factors Krüppel-like factor 4 and paired box 5 regulate the expression of the Grainyhead-like genes.

PLoS ONE, 2021
Genes from the Grainyhead-like (GRHL) family code for transcription factors necessary for the development and maintenance of various epithelia. These genes are also very important in the development of many types of cancer. However, little is known about
Grzegorz Kotarba, Agnieszka Taracha-Wisniewska, Michal Miller, Michal Dabrowski, Tomasz Wilanowski   +4 more
doaj   +1 more source

Cell-specific Transcription of Leukotriene C4Synthase Involves a Kruppel-like Transcription Factor and Sp1 [PDF]

Journal of Biological Chemistry, 2000
Leukotriene C(4) synthase (LTC(4)S) is responsible for the biosynthesis of cysteinyl leukotrienes that participate in allergic and asthmatic inflammation. We analyzed 2.1 kilobases of the 5'-flanking region of the human LTC(4)S gene, which contains three DNase I hypersensitivity sites, for its transcriptional activity when fused to a promoterless and ...
J L, Zhao, K F, Austen, B K, Lam
openaire   +2 more sources

The Kruppel‐like transcription factor KLF13 is a novel regulator of heart development [PDF]

The EMBO Journal, 2006
In humans, congenital heart defects occur in 1-2% of live birth, but the molecular mechanisms and causative genes remain unidentified in the majority of cases. We have uncovered a novel transcription pathway important for heart morphogenesis. We report that KLF13, a member of the Krüppel-like family of zinc-finger proteins, is expressed predominantly ...
Nemer, Georges, Horb, Marko E., Nemer, Mona, Nadeau, Mathieu, Lefebvre, Chantal, Lavallée, Geneviève, Andelfinger, Gregor   +6 more
openaire   +3 more sources

Lung Kruppel-like Factor, a Zinc Finger Transcription Factor, Is Essential for Normal Lung Development [PDF]

Journal of Biological Chemistry, 1999
Lung Kruppel-like factor (LKLF) is a member of the Kruppel-like factor family of transcription factors and is highly expressed in lung with limited distribution in other tissues. Mice lacking LKLF due to inactivation of LKLF by gene targeting die in utero at midgestation around day 12.5 due to severe hemorrhage, making it difficult to study the role of
M A, Wani, S E, Wert, J B, Lingrel
openaire   +2 more sources

Deoxycholic Acid Upregulates the Reprogramming Factors KFL4 and OCT4 Through the IL-6/STAT3 Pathway in Esophageal Adenocarcinoma Cells

Technology in Cancer Research & Treatment, 2020
Cancer stem cells, a special subgroup of cancer cells, have self-renewal capabilities and multidirectional potential, which may be reprogrammed from the dedifferentiation of cancer cells, contributing to the failure of clinical treatments.
Mei Chen BSc, AXiaojun Ye MSc, Jingxi Wei BSc, Ruihua Wang MD, Karen Poon PhD   +4 more
doaj   +1 more source

Kruppel-like factor 4 is critical for transcriptional control of cardiac mitochondrial homeostasis [PDF]

Journal of Clinical Investigation, 2015
Mitochondrial homeostasis is critical for tissue health, and mitochondrial dysfunction contributes to numerous diseases, including heart failure. Here, we have shown that the transcription factor Kruppel-like factor 4 (KLF4) governs mitochondrial biogenesis, metabolic function, dynamics, and autophagic clearance.
Xudong, Liao, Rongli, Zhang, Yuan, Lu, Domenick A, Prosdocimo, Panjamaporn, Sangwung, Lilei, Zhang, Guangjin, Zhou, Puneet, Anand, Ling, Lai, Teresa C, Leone, Hisashi, Fujioka, Fang, Ye, Mariana G, Rosca, Charles L, Hoppel, P Christian, Schulze, E Dale, Abel, Jonathan S, Stamler, Daniel P, Kelly, Mukesh K, Jain   +18 more
openaire   +2 more sources

Krüppel-like factors in cancer progression: three fingers on the steering wheel [PDF]

, 2013
Kruppel-like factors (KLFs) comprise a highly conserved family of zinc finger transcription factors, that are involved in a plethora of cellular processes, ranging from proliferation and apoptosis to differentiation, migration and pluripotency.
de Beeck, Ken Op, De Wever, Olivier, Lardon, Filip, LIMAME, RIDHA, Pauwels, Patrick   +4 more
core   +3 more sources

Role of kruppel-like transcription factors in adipogenesis

Developmental Biology, 2013
The zinc-finger transcription factors of the kruppel-like factor family (KLF) are critical in many physiological and pathological processes including cell proliferation, differentiation, inflammation, and apoptosis. Recently, there is increasing evidence that suggests these KLFs have an important role in fat biology.
Wu, Zeni, Wang, Suqing
openaire   +2 more sources