Results 11 to 20 of about 33,501 (214)

Krüppel-like transcription factors and control of pluripotency [PDF]

BMC Biology, 2010
Recent papers have demonstrated a role for Krüppel-like transcription factors 2, 4 and 5 in the control of mouse embryonic stem cell pluripotency. However, it is not clear whether each factor has a unique role or whether they are functionally redundant ...
Bourillot Pierre-Yves, Savatier Pierre
doaj   +2 more sources

Abnormal expression of Krüppel-like transcription factors and their potential values in lung cancer [PDF]

Heliyon
Lung cancer still is one of the most common malignancy tumors in the world. However, the mechanisms of its occurrence and development have not been fully elucidated.
Yang Shi, Min Yao, Shuijie Shen, Li Wang, Dengfu Yao   +4 more
doaj   +2 more sources

Krüppel-like transcription factors KLF1 and KLF2 have unique and coordinate roles in regulating embryonic erythroid precursor maturation [PDF]

Haematologica, 2014
The Krüppel-like transcription factors KLF1 and KLF2 are essential for embryonic erythropoiesis. They can partially compensate for each other during mouse development, and coordinately regulate numerous erythroid genes, including the β-like globins ...
Divya S. Vinjamur, Kristen J. Wade, Safa F. Mohamad, Jack L. Haar, Stephen T. Sawyer, Joyce A. Lloyd   +5 more
doaj   +2 more sources

Krüppel-like factor 4 control of immune cell function [PDF]

Frontiers in Immunology
Krüppel-like factor 4 (KLF4) belongs to a family of transcription factors that contain conserved zinc finger DNA binding domains, including specificity proteins (SPs) and Krüppel-like factors (KLFs).
Tapatee Das, Elaine Wang, Yitian Xu, Harrison Yang, Xudong Liao, Mukesh K. Jain, Mukesh K. Jain   +6 more
doaj   +2 more sources

KLF7 is a general inducer of human pluripotency [PDF]

EMBO Reports
Pluripotency is the capacity to generate all somatic cells and the germ line and is governed by a self-reinforcing network of transcription factors.
Mattia Arboit, Irene Zorzan, Eleonora Pensabene, Marco Pellegrini, Federica Bertelli, Giorgia Panebianco, Davide Benvegnù, Giada Rossignoli, Paolo Martini, Gianluca Amadei, Elena Carbognin, Graziano Martello   +11 more
doaj   +2 more sources

Endothelial cell activation by antiphospholipid antibodies is modulated by Kruppel-like transcription factors.

Blood, 2011
Abstract Antiphospholipid syndrome is characterized by thrombosis and/or recurrent pregnancy loss in the presence of antiphospholipid antibodies (APLAs). The majority of APLAs are directed against phospholipid-binding proteins, particularly β2-glycoprotein I (β2GPI).
Allen KL, Hamik A, Jain MK, McCrae KR.
europepmc   +4 more sources

Krüppel-like factors in mitochondrial quality control [PDF]

Frontiers in Physiology
Krüppel-like factors (KLFs) are a group of transcription factors characterized by conserved zinc finger domains in the C-terminus, which are critically involved in basic cellular processes, including growth, differentiation, apoptosis, and angiogenesis ...
M. Y. Zhang, H. Zhang, Y. M. Yao, D. W. Yang   +3 more
doaj   +2 more sources

Molecular basis for modulation of the p53 target selectivity by KLF4 [PDF]

, 2012
The tumour suppressor p53 controls transcription of various genes involved in apoptosis, cell-cycle arrest, DNA repair and metabolism. However, its DNA-recognition specificity is not nearly sufficient to explain binding to specific locations in vivo ...
Brandt, Tobias, Freund, Stefan M. V., Teufel, Daniel P., Townsley, Fiona M., Veprintsev, Dmitry B.   +4 more
core   +16 more sources

Kruppel-like Transcription Factor 6 Regulates Inflammatory Macrophage Polarization [PDF]

Journal of Biological Chemistry, 2014
Accumulating evidence supports the importance of macrophage plasticity in a broad spectrum of biological processes operative in health and disease. A major locus of control regulating macrophage polarization is at the transcriptional level, and several major pathways have been elucidated in recent years.
Dipali, Date, Riku, Das, Goutham, Narla, Daniel I, Simon, Mukesh K, Jain, Ganapati H, Mahabeleshwar   +5 more
openaire   +2 more sources

Suppression of glioblastoma tumorigenicity by the Kruppel-like transcription factor KLF6 [PDF]

Oncogene, 2004
The Kruppel-like transcription factor KLF6 is a novel tumor-suppressor gene mutated in a significant fraction of human prostate cancer. It is localized to human chromosome 10p14-15, a region that displays frequent loss of heterozygosity in glioblastoma multiforme (GBM).
Alec C, Kimmelman, Rui F, Qiao, Goutham, Narla, Asoka, Banno, Nelson, Lau, Paula D, Bos, Nelson, Nuñez Rodriguez, Bertrand C, Liang, Abhijit, Guha, John A, Martignetti, Scott L, Friedman, Andrew M, Chan   +11 more
openaire   +2 more sources