Results 31 to 40 of about 33,501 (214)

MicroRNAs-Proteomic Networks Characterizing Human Medulloblastoma-SLCs [PDF]

, 2016
Medulloblastoma (MB) is the most common malignant brain tumor of pediatric age and is characterized by cells expressing stem, astroglial, and neuronal markers.
Alfano, Vincenzo, Besharat, ZEIN MERSINI, Carai, Andrea, Catanzaro, Giuseppina, Ferretti, Elisabetta, Garg, Neha, Locatelli, Franco, Mastronuzzi, Angela, Miele, Evelina, Pieroni, Luisa, Po, Agnese, Ronci, Maurizio, Screpanti, Isabella, Urbani, Andrea   +13 more
core   +4 more sources

Transcriptional repression of Kruppel like factor‐2 by the adaptor protein p66shc

The FASEB Journal, 2009
ABSTRACT The adaptor protein p66shc promotes cellular oxidative stress and apoptosis. Here, we demonstrate a novel mechanistic relationship between p66shc and the kruppel like factor‐2 (KLF2) transcription factor and show that this relationship has biological relevance to p66shc‐regulated cellular oxidant level ...
Ajay, Kumar, Timothy A, Hoffman, Jeremy, Dericco, Asma, Naqvi, Mukesh K, Jain, Kaikobad, Irani   +5 more
openaire   +3 more sources

Cutting Edge: The Transcription Factor Kruppel-Like Factor 4 Regulates the Differentiation of Th17 Cells Independently of RORγt [PDF]

The Journal of Immunology, 2010
Abstract Th17 cells play a significant role in inflammatory and autoimmune responses. Although a number of molecular pathways that contribute to the lineage differentiation of T cells have been discovered, the mechanisms by which lineage commitment occurs are not fully understood.
Lori, Lebson, Anne, Gocke, Jason, Rosenzweig, Jonathan, Alder, Curt, Civin, Peter A, Calabresi, Katharine A, Whartenby   +6 more
openaire   +2 more sources

Transcriptional Regulation of Macrophages Polarization by MicroRNAs

Frontiers in Immunology, 2018
Diversity and plasticity are the hallmarks of cells from the monocyte–macrophage lineage. Macrophages undergo classical M1 or alternative M2 activation in response to the microenvironment signals.
Heng Li, Ting Jiang, Meng-Qi Li, Xi-Long Zheng, Xi-Long Zheng, Guo-Jun Zhao, Guo-Jun Zhao   +6 more
doaj   +1 more source

Role of Esrrg in the Fibrate-Mediated Regulation of Lipid Metabolism Genes in Human ApoA-I Transgenic Mice [PDF]

, 2009
We have used a new ApoA-I transgenic mouse model to identify by global gene expression profiling, candidate genes that affect lipid and lipoprotein metabolism in response to fenofibrate treatment.
A Chroni, A Duka, A Patsialou, A Rigotti, A Walsh, AP Feinberg, B Staels, B Staels, B Staels, B Staels, B Staels, B Staels, BN Finck, CW Miller, D Arsenijevic, D Lan, D Sanoudou, D Sanoudou, D Sanoudou, EM Rubin, ES Cathcart, F Yadetie, G Fredrikson, G Martin, H Duez, H Samyn, HB Rubins, HY Kan, J Karbowska, J Lin, J St Pierre, JC Fruchart, JD Brunzell, JJ Lehman, JK Reddy, JL Goldstein, JM Huss, JM Huss, JP Desager, K C Hayes, K Drosatos, K Motojima, K Schoonjans, K Schoonjans, KE Kypreos, KE Kypreos, KS Frederiksen, L Berthou, LA Pennacchio, LJ Kelly, M Bouly, MB Eisen, MC Hunt, MJ Holness, N Hennuyer, N Vu-Dac, N Vu-Dac, N Vu-Dac, N Vu-Dac, NF Cariello, P Puigserver, Q Guo, R Sladek, RB Vega, RL Jacobs, SA Greenberg, SN Schreiber, V Beisvag, V Giguere, V I Zannis, V Litvak, VG Tusher, VI Zannis, VI Zannis, VI Zannis, WC Roberts, X Prieur, Y Kamei, Y Nagai, Z Wu   +79 more
core   +3 more sources

Transcriptional repression of the tyrosinase-related protein 2 gene by transforming growth factor-β and the Kruppel-like transcription factor GLI2 [PDF]

Journal of Dermatological Science, 2019
Tyrosinase-Related Protein 2 (TRP2) is an enzyme involved in melanogenesis, that also exerts proliferative, anti-apoptotic and immunogenic functions in melanoma cells. TRP2 transcription is regulated by the melanocytic master transcription factor MITF.
Pierrat, Marie-Jeanne, Marsaud, Véronique, Mauviel, Alain, Javelaud, Delphine   +3 more
openaire   +3 more sources

Kruppel-Like Factor 2 Is a Transcriptional Regulator of Chronic and Acute Inflammation

The American Journal of Pathology, 2013
Although myeloid cell activation is requisite for an optimal innate immune response, this process must be tightly controlled to prevent collateral host tissue damage. Kruppel-like factor 2 (KLF2) is a potent regulator of myeloid cell proinflammatory activation.
Nayak, Lalitha, Goduni, Lediana, Takami, Yoichi, Sharma, Nikunj, Kapil, Parul, Jain, Mukesh K., Mahabeleshwar, Ganapati H.   +6 more
openaire   +2 more sources

Zebrafish Vestigial Like Family Member 4b Is Required for Valvulogenesis Through Sequestration of Transcription Factor Myocyte Enhancer Factor 2c

Frontiers in Cell and Developmental Biology, 2019
A variety of cardiac transcription factors/cofactors, signaling pathways, and downstream structural genes integrate to form the regulatory hierarchies to ensure proper cardiogenesis in vertebrate.
Chang Xue, Xiaohui Liu, Bin Wen, Ruimeng Yang, Shuo Gao, Jiong Tao, Jun Zhou   +6 more
doaj   +1 more source

Kruppel-like Factor-9 (KLF9) Inhibits Glioblastoma Stemness through Global Transcription Repression and Integrin α6 Inhibition [PDF]

Journal of Biological Chemistry, 2014
It is increasingly important to understand the molecular basis for the plasticity of neoplastic cells and their capacity to transition between differentiated and stemlike phenotypes. Kruppel-like factor-9 (KLF9), a member of the large KLF transcription factor family, has emerged as a regulator of oncogenesis, cell differentiation, and neural ...
Mingyao, Ying, Jessica, Tilghman, Yingying, Wei, Hugo, Guerrero-Cazares, Alfredo, Quinones-Hinojosa, Hongkai, Ji, John, Laterra   +6 more
openaire   +2 more sources

GATA Binding Protein 3 Is a Direct Target of Kruppel-Like Transcription Factor 7 and Inhibits Chicken Adipogenesis [PDF]

Frontiers in Physiology, 2020
Kruppel-like transcription factor 7 (KLF7) is a negative regulator of adipogenesis, however, its precise mechanism is poorly understood. Our previous KLF7 ChIP-seq analysis showed that one of the KLF7 binding peaks was present upstream of GATA binding protein 3 (GATA3) in chicken preadipocytes.
Yingning Sun, Yingning Sun, Yingning Sun, Yingning Sun, Zhao Jin, Xinyang Zhang, Xinyang Zhang, Xinyang Zhang, Tingting Cui, Tingting Cui, Tingting Cui, Tingting Cui, Wenjian Zhang, Wenjian Zhang, Wenjian Zhang, Shuli Shao, Hui Li, Hui Li, Hui Li, Ning Wang, Ning Wang, Ning Wang   +21 more
openaire   +3 more sources