Simvastatin has an anti-inflammatory effect on macrophages via upregulation of an atheroprotective transcription factor, Kruppel-like factor 2 [PDF]
Cardiovascular Research, 2008 Statins have beneficial vascular effects beyond their cholesterol-lowering action. Since macrophages play a central role in atherogenesis, we characterized the effects of simvastatin on gene expression profile of human peripheral blood monocyte (HPBM)-macrophages.Gene expression profile was studied using Affymetrix gene chip analysis.
Tuomisto, T.T. +8 more
openaire +5 more sources
Protein Kinase C δ Increases Kruppel-like Factor 4 Protein, which Drives Involucrin Gene Transcription in Differentiating Keratinocytes [PDF]
Journal of Biological Chemistry, 2013 KLF4 is a member of the Kruppel-like factor family of transcriptional regulators. KLF4 has been shown to be required for normal terminal differentiation of keratinocytes, but the molecular mechanism whereby KLF4 regulates genes associated with the differentiation process has not been studied.
Richard L. Eckert +4 more
openaire +3 more sources
Kruppel-like Factor-9 (KLF9) Inhibits Glioblastoma Stemness through Global Transcription Repression and Integrin α6 Inhibition [PDF]
Journal of Biological Chemistry, 2014 It is increasingly important to understand the molecular basis for the plasticity of neoplastic cells and their capacity to transition between differentiated and stemlike phenotypes. Kruppel-like factor-9 (KLF9), a member of the large KLF transcription factor family, has emerged as a regulator of oncogenesis, cell differentiation, and neural ...
Yingying Wei +6 more
openaire +4 more sources
Genome-wide ChIP-Seq reveals a dramatic shift in the binding of the transcription factor erythroid Kruppel-like factor during erythrocyte differentiation [PDF]
Blood, 2011 Abstract Erythropoiesis is dependent on the activity of transcription factors, including the erythroid-specific erythroid Kruppel-like factor (EKLF). ChIP followed by massively parallel sequencing (ChIP-Seq) is a powerful, unbiased method to map trans-factor occupancy.
Praveen F. Cherukuri +11 more
openaire +5 more sources
The transcription factor Gbx2 induces expression of Kruppel-like factor 4 to maintain and induce naïve pluripotency of embryonic stem cells [PDF]
Journal of Biological Chemistry, 2017 The transcription factor Gbx2 (gastrulation brain homeobox 2) is a direct target of the LIF/STAT3 signaling pathway, maintains mouse embryonic stem cell (mESC) self-renewal, and facilitates mouse epiblast stem cell (mEpiSC) reprogramming to naïve pluripotency.
Manman Wang +4 more
openaire +4 more sources
The pluripotency transcription factor Kruppel-like factor 4 is strongly expressed in intratubular germ cell neoplasia unclassified and seminoma [PDF]
Molecular Human Reproduction, 2009 Germ cell tumors of the testis are the most frequent tumors in men between 20 and 40 years. Their most common subtype is the seminoma, which arises like the embryonal carcinoma from an intratubular germ cell neoplasia unclassified (IGCNU), i.e. fetal germ cells that escaped from the control of the developing testicular stem cell niche, eventually ...
Godmann, M. +6 more
openaire +5 more sources
Blood, 2011 Abstract Antiphospholipid syndrome is characterized by thrombosis and/or recurrent pregnancy loss in the presence of antiphospholipid antibodies (APLAs). The majority of APLAs are directed against phospholipid-binding proteins, particularly β2-glycoprotein I (β2GPI).
Allen KL, Hamik A, Jain MK, McCrae KR.
europepmc +5 more sources
Induction of T‐Cell Differentiation by KLF4 in T‐Cell Acute Lymphoblastic Leukemia Cells Harboring Activating Mutation in NOTCH3 [PDF]
The FASEB Journal, Volume 39, Issue 10, 31 May 2025.KLF4‐induced T‐cell differentiation and apoptosis in TALL‐1 cells harboring an activating mutation in NOTCH3. KLF4 directly downregulated NOTCH3 expression by binding to its promoter, thereby promoting the differentiation of CD4/CD8 double‐positive cells into CD4 single‐positive cells, with the differentiated cells subsequently undergoing apoptosis ...
Mina Noura +3 more
wiley +2 more sources
Journal of Forensic Science and Medicine, 2022 Background: Accumulated studies have demonstrated that Kruppel-like factor 5 (KLF5), a transcription factor, plays an important role in regulating cell proliferation and tissue remodeling through the expression of its downstream genes.
Xingyu Ma +7 more
doaj +2 more sources
Tcf7l1 promotes transcription of Kruppel-like factor 4 during Xenopus embryogenesis
The Journal of Biomedical Research, 2018 Kruppel-like factor 4 (Klf4) is a zinc finger transcriptionfactor and plays crucial roles in Xenopus embryogenesis. However, its regulation during embryogenesis is stillunclear. Here, we report that Tcf7l1, a key downstream transducerof the Wnt signaling pathway, could promote Klf4 transcription and stimulate Klf4 promoter activity in early Xenopus ...
Chen Liu +4 more
openaire +4 more sources