Results 51 to 60 of about 33,501 (214)
Blood, 2014 Key Points Transcription factor KLF2 is a critical determinant of vascular thrombosis. The antithrombotic effect noted with bortezomib is KLF2 dependent.
Lalitha, Nayak +5 more
openaire +3 more sources
Transcriptional Activity of Erythroid Kruppel-like Factor (EKLF/KLF1) Modulated by PIAS3 (Protein Inhibitor of Activated STAT3) [PDF]
Journal of Biological Chemistry, 2015 Erythroid Kruppel-like factor (EKLF or KLF1) is a transcription factor crucial for red cell development that is directly involved in regulation of a large number of erythroid genes. EKLF serves mostly as an activator of expression of these genes; however, it can act also as a repressor.
Miroslawa, Siatecka +3 more
openaire +2 more sources
Viruses, 2021 Following acute infection, herpes simplex virus 1 (HSV-1) establishes lifelong latency in neurons, including sensory neurons within trigeminal ganglia. During latency, lytic cycle viral gene expression is silenced.
Jeffery B. Ostler, Clinton Jones
doaj +1 more source
Role of noncoding RNA in vascular remodelling [PDF]
, 2016 Purpose of review: Noncoding RNAs (ncRNAs), such as microRNAs (miRNAs) and long noncoding RNAs (lncRNAs) are becoming fundamentally important in the pathophysiology relating to injury-induced vascular remodelling.
Baker, Andrew H. +2 more
core +1 more source
Interaction of PRP4 with Krüppel-Like Factor 13 Regulates CCL5 Transcription [PDF]
The Journal of Immunology, 2007 Abstract Activation of resting T lymphocytes initiates differentiation into mature effector cells over 3–7 days. The chemokine CCL5 (RANTES) and its major transcriptional regulator, Krüppel-like factor 13 (KLF13), are expressed late (3–5 days) after activation in T lymphocytes.
Boli, Huang +4 more
openaire +2 more sources
Materials Today Bio, 2021 Induced pluripotent stem cells are usually derived by reprogramming transcription factors (OSKM), such as octamer-binding transcription factor 4 (OCT4), (sex determining region Y)-box 2 (SOX2), Krüppel-like factor 4 (KLF4), and cellular proto-oncogene (c-
Mei-Hwa Lee +4 more
doaj +1 more source
Krüppel-Like Transcription Factor 13 Regulates T Lymphocyte Survival In Vivo [PDF]
The Journal of Immunology, 2007 Abstract Krüppel-like transcription factor (KLF)13, previously shown to regulate RANTES expression in vitro, is a member of the Krüppel- like family of transcription factors that controls many growth and developmental processes. To ascertain the function of KLF13 in vivo, Klf13-deficient mice were generated by gene targeting.
Meixia, Zhou +11 more
openaire +2 more sources
Repression of cardiac hypertrophy by KLF15: underlying mechanisms and therapeutic implications.
PLoS ONE, 2012 The Kruppel-like factor (KLF) family of transcription factors regulates diverse cell biological processes including proliferation, differentiation, survival and growth. Previous studies have shown that KLF15 inhibits cardiac hypertrophy by repressing the
Joost J Leenders +8 more
doaj +1 more source
Aberrant regulation of FBW7 in cancer [PDF]
, 2014 FBW7 (F-box and WD repeat domain-containing 7) or Fbxw7 is a tumor suppressor, which promotes the ubiquitination and subsequent degradation of numerous oncoproteins including Mcl-1, Cyclin E, Notch, c- Jun, and c-Myc.
Liu, Yueyong +4 more
core +1 more source
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019 Background We previously reported that vascular smooth muscle cells (VSMCs) from spontaneously hypertensive rats (SHRs) show the increased expression of complement 3 (C3) and the synthetic phenotype.
Lan Chen +7 more
doaj +1 more source