PLoS ONE, 2022 Progression of virtually all forms of chronic kidney disease (CKD) is associated with activation of pro-inflammatory and pro-fibrotic signaling pathways.
Silvana B. De Lorenzo +7 more
doaj +3 more sources
Krüppel-like factors in cancer progression: three fingers on the steering wheel [PDF]
, 2013 Kruppel-like factors (KLFs) comprise a highly conserved family of zinc finger transcription factors, that are involved in a plethora of cellular processes, ranging from proliferation and apoptosis to differentiation, migration and pluripotency.
de Beeck, Ken Op +4 more
core +3 more sources
Transcriptional Regulation of Macrophages Polarization by MicroRNAs
Frontiers in Immunology, 2018 Diversity and plasticity are the hallmarks of cells from the monocyte–macrophage lineage. Macrophages undergo classical M1 or alternative M2 activation in response to the microenvironment signals.
Heng Li +6 more
doaj +1 more source
Transcriptional repression of WEE1 by Kruppel-like factor 2 is involved in DNA damage-induced apoptosis [PDF]
Oncogene, 2005 Human Kruppel-like factor 2 (KLF2) is a Cys(2)/His(2) zinc-finger-containing transcriptional factor, which is involved in multiple cellular pathways. Utilizing gene expression profiling to identify aberrantly expressed genes in ovarian cancer, we found that KLF2 was significantly and specifically downregulated in ovarian tumors.
Ngan, HYS +12 more
openaire +4 more sources
Control of globin gene expression by Kruppel-like factors [PDF]
, 2014 Kruppel-like factors (KLFs) are a family of seventeen proteins designated KLF1 to KLF17. KLFs are transcriptional factors that bind GC-rich sequences such as CACCC elements. The DNA binds to KLFs via three carboxyl-terminal Cys-2/His-2 zinc fingers. KLFs
Borg, Joseph, Grech, Laura
core +1 more source
Differential regulation of Krüppel-like factor family transcription factor expression in neonatal rat cardiac myocytes: effects of endothelin-1, oxidative stress and cytokines [PDF]
, 2008 Krüppel-like transcription factors (Klfs) modulate fundamental cell processes. Cardiac myocytes are terminally-differentiated, but hypertrophy in response to stimuli such as endothelin-1. H2O2 or cytokines promote myocyte apoptosis. Microarray studies of
Ahmad +61 more
core +2 more sources
Transcription Factors as Therapeutic Targets in Chronic Kidney Disease
Molecules, 2018 The growing number of patients with chronic kidney disease (CKD) is recognized as an emerging problem worldwide. Recent studies have indicated that deregulation of transcription factors is associated with the onset or progression of kidney disease ...
Akihito Hishikawa +2 more
doaj +1 more source
Global analysis of gene expression mediated by OX1 orexin receptor signaling in a hypothalamic cell line. [PDF]
PLoS ONE, 2017 The orexins and their cognate G-protein coupled receptors have been widely studied due to their associations with various behaviors and cellular processes.
Eric Koesema, Thomas Kodadek
doaj +1 more source
3D polymer simulations of genome organization and transcription across different chromosomes and cell types [PDF]
, 2022 We employ the diffusing transcription factors model for numerical simulation of chromatin topology conformations and transcriptional processes of human chromatin. Simulations of a short chromatin filament reveal different possible pathways to regulate transcription: it is shown that the transcriptional activity profile can be regulated and controlled ...
arxiv +1 more source
Erythroid Kruppel-like factor directly activates the basic Kruppel-like factor gene in erythroid cells [PDF]
, 2007 The Sp/Kriippel-like factor (Sp/KIf) family is comprised of around 25 zinc finger transcription factors that recognize CACCC boxes and GC-rich elements.
Crossley, Merlin +6 more
core +1 more source