Results 81 to 90 of about 33,501 (214)

Klf4, Klf2, and Zfp148 activate autophagy‐related genes in smooth muscle cells during aortic aneurysm formation

Physiological Reports, 2019
Abdominal aortic aneurysms (AAAs) are a progressive dilation of the aorta that is characterized by an initial influx of inflammatory cells followed by a pro‐inflammatory, migratory, proliferative, and eventually apoptotic smooth muscle cell phenotype. In
Morgan Salmon, Michael Spinosa, Zendra E. Zehner, Gilbert R. Upchurch, Gorav Ailawadi   +4 more
doaj   +1 more source

Krüppel-like factor 6 regulates transforming growth factor-β gene expression during human respiratory syncytial virus infection

Virology Journal, 2011
Background Human respiratory syncytial virus (RSV) infection is associated with airway remodeling and subsequent asthma development. Transforming growth factor-beta (TGF) plays a crucial role in asthma development.
Chang TeHung, Segovia Jesus, Mgbemena Victoria, Bose Santanu   +3 more
doaj   +1 more source

Cooperative contributions of the klf1 and klf17 genes in zebrafish primitive erythropoiesis

Scientific Reports, 2023
Krüppel-like transcription factors (Klfs), which are characterized by the three conserved C-terminal zinc fingers, are involved in various biological processes, such as haematopoiesis and angiogenesis. However, how the Klf family of transcription factors
Hiroaki Suzuki, Tomotaka Ogawa, Shigeyoshi Fujita, Ryota Sone, Atsuo Kawahara   +4 more
doaj   +1 more source

Genome wide expression profiling reveals suppression of host defence responses during colonisation by Neisseria meningitides but not N. lactamica. [PDF]

, 2011
Both Neisseria meningitidis and the closely related bacterium Neisseria lactamica colonise human nasopharyngeal mucosal surface, but only N. meningitidis invades the bloodstream to cause potentially life-threatening meningitis and septicaemia.
Hibberd, Martin L, Kroll, J Simon, Langford, Paul R, Li, Ming-Shi, Wong, Hazel En En   +4 more
core   +1 more source

miR‐135a‐5p Is a Promising Target to Prevent the Glomerulosclerosis Associated with Podocyte Developmental Toxicity in Offspring Induced by Prenatal Dexamethasone Exposure

Advanced Science, EarlyView.
Prenatal dexamethasone exposure (PDE) programs persistent podocyte developmental injury and adult glomerulosclerosis. Mechanistically, glucocorticoid receptor (GR) binds the miR‐135a‐5p promoter and recruits the histone acetyltransferase p300, increasing promoter histone acetylation and sustaining miR‐135a‐5p expression. Elevated miR‐135a‐5p suppresses
Xiaoqi Zhao, Haiyun Chen, Yanan Zhu, Zhiping Xia, Hangyuan He, Yutang Liu, Tianshu Yang, Hui Wang, Ying Ao   +8 more
wiley   +1 more source

Exploring the Functionality of the Krüppel-like Factors in Kidney Development, Metabolism, and Diseases

Life
The kidneys contribute to the overall health of an organism by maintaining systemic homeostasis. This process involves various biological mechanisms, in which the Krüppel-like factors (KLFs), a family of transcription factors, are essential for ...
Itzel S. Salmon-Cabrales, David A. de la Garza-Kalife, Gabriel García-González, Ana E. Estrada-Rodríguez, Marco Antonio Jiménez-Gutiérrez, Michelle G. Santoyo-Suárez, Oscar Rodríguez-Núñez, Elsa N. Garza-Treviño, Diego F. Benítez-Chao, Gerardo R. Padilla-Rivas, Jose Francisco Islas   +10 more
doaj   +1 more source

The transcription factor Gbx2 induces expression of Kruppel-like factor 4 to maintain and induce naïve pluripotency of embryonic stem cells [PDF]

Journal of Biological Chemistry, 2017
The transcription factor Gbx2 (gastrulation brain homeobox 2) is a direct target of the LIF/STAT3 signaling pathway, maintains mouse embryonic stem cell (mESC) self-renewal, and facilitates mouse epiblast stem cell (mEpiSC) reprogramming to naïve pluripotency.
Manman, Wang, Ling, Tang, Dahai, Liu, Qi-Long, Ying, Shoudong, Ye   +4 more
openaire   +2 more sources

Autosomal Dominant Erythrocytosis Caused by Non‐Renal Erythropoietin (EPO) Due to EPO c.‐136 G>A Germline Mutation

American Journal of Hematology, EarlyView.
A novel erythropoietin (EPO) promoter mutation (c.‐136 G>A) causes autosomal dominant erythrocytosis via non‐renal expression of EPO. ABSTRACT We previously reported a five‐generation kindred with autosomal dominant erythrocytosis associated with a novel germline promoter variant in the erythropoietin (EPO) gene (EPO c.‐136 G>A).
Lucie Lanikova, Dusan Hrckulak, Veronika Zimolova, Felipe R. Lorenzo, Jihyun Song, Katerina Vecerkova, Olga Babosova, Linda Berkova, Vladimir Korinek, Steve Elliott, Josef T. Prchal   +10 more
wiley   +1 more source

Single-Cell Transcriptomics Reveals Zone-Specific Alterations of Liver Sinusoidal Endothelial Cells in CirrhosisSummary

Cellular and Molecular Gastroenterology and Hepatology, 2021
Background: Dysfunction of liver sinusoidal endothelial cells (LSECs) is permissive for the progression of liver fibrosis and cirrhosis and responsible for its clinical complications.
Tingting Su, Yilin Yang, Sanchuan Lai, Jain Jeong, Yirang Jung, Matthew McConnell, Teruo Utsumi, Yasuko Iwakiri   +7 more
doaj   +1 more source

Promoter keyholes enable specific and persistent multi-gene expression programs in primary T cells without genome modification [PDF]

, 2020
Non-invasive epigenome editing is a promising strategy for engineering gene expression programs, yet potency, specificity, and persistence remain challenging.
Acosta, Reyes, Baker, David, Bates, Daniel, Bloom, Jordan, Boyken, Scott E., Chen, Zibo, Ciarlo, Christie, Dunn, Douglass, Federation, Alexander, Funnell, Alister, Green, Shon, Heberlein, Gregory, Liao, Hanna, Nandakumar, Vivek, Otterman, Ericka, Pearl, Jocelynn, Queitsch, Konstantin, Sandstrom, Richard, Schanzer, Elaine, Stamatoyannopoulos, John A., Urnov, Fyodor D., Van Biber, Benjamin, Vong, Shinny, Wang, Hao, Wilken, Matthew S., Zrazhevskey, Pavel   +25 more
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