Results 81 to 90 of about 193,609 (276)
Bioinformatics analysis of the early inflammatory response in a rat thermal injury model
BMC Bioinformatics, 2007 Background Thermal injury is among the most severe forms of trauma and its effects are both local and systemic. Response to thermal injury includes cellular protection mechanisms, inflammation, hypermetabolism, prolonged catabolism, organ dysfunction and
Berthiaume Francois +4 more
doaj +1 more source
Identification and analysis of KLF13 variants in patients with congenital heart disease
BMC Medical Genetics, 2020 Background The protein Kruppel-like factor 13 (KLF13) is a member of the KLF family and has been identified as a cardiac transcription factor that is involved in heart development.
Wenjuan Li +6 more
doaj +1 more source
Cell Death Discovery, 2022 Misalignment of physiological circadian rhythms promotes obesity which is characterized by white adipose tissue (WAT) expansion. Differentiation of Adipose stem/progenitor cells (ASCs) contributes to WAT increase but the importance of the cellular clock ...
Markus Mandl +14 more
doaj +1 more source
Frontiers in Immunology, 2023 cDC2s occur abundantly in peripheral tissues and arise from circulating blood cDC2s. However, the factors governing cDC2 differentiation in tissues, especially under inflammatory conditions, remained poorly defined.
Magdalena Lang +8 more
doaj +1 more source
Functional Evolution of a cis-Regulatory Module [PDF]
, 2005 Lack of knowledge about how regulatory regions evolve in relation to their structure–function may limit the utility of comparative sequence analysis in deciphering cis-regulatory sequences.
Alekseeva, Elena +5 more
core +4 more sources
Transcription Factor KLF10 Constrains IL-17-Committed Vγ4+ γδ T Cells
Frontiers in Immunology, 2018 γδ T cells, known to be an important source of innate IL-17 in mice, provide critical contributions to host immune responses. Development and function of γδ T cells are directed by networks of diverse transcription factors (TFs).
Girak Kim +14 more
doaj +1 more source
How the DNA sequence affects the Hill curve of transcriptional response [PDF]
Phys. Biol. 9 (2012) 056006, 2011 The Hill coefficient is often used as a direct measure of the cooperativity of binding processes. It is an essential tool for probing properties of reactions in many biochemical systems. Here we analyze existing experimental data and demonstrate that the Hill coefficient characterizing the binding of transcription factors to their cognate sites can in ...
arxiv +1 more source
Genome wide expression profiling reveals suppression of host defence responses during colonisation by Neisseria meningitides but not N. lactamica. [PDF]
, 2011 Both Neisseria meningitidis and the closely related bacterium Neisseria lactamica colonise human nasopharyngeal mucosal surface, but only N. meningitidis invades the bloodstream to cause potentially life-threatening meningitis and septicaemia.
Hibberd, Martin L +4 more
core +1 more source
Critical Role of microRNA-21 in the Pathogenesis of Liver Diseases [PDF]
, 2020 MicroRNAs are small non-coding RNAs that range in length from 18 to 24 nucleotides. As one of the most extensively studied microRNAs, microRNA-21 (miR-21) is highly expressed in many mammalian cell types.
Han, Sen +4 more
core +1 more source
Extending the dynamic range of transcription factor action by translational regulation [PDF]
Phys. Rev. E 93, 022404 (2016), 2015 A crucial step in the regulation of gene expression is binding of transcription factor (TF) proteins to regulatory sites along the DNA. But transcription factors act at nanomolar concentrations, and noise due to random arrival of these molecules at their binding sites can severely limit the precision of regulation.
arxiv +1 more source