Results 11 to 20 of about 24,542 (261)

Cross-Species Insights Into Gamma Herpesvirus Transcriptomes: Long-Read and Multi-Omics Perspectives. [PDF]

J Med Virol
ABSTRACT Comparative transcriptome analyses of gamma herpesviruses have been revolutionized by long‐read sequencing and integrative multi‐omics approaches, enabling unprecedented resolution of viral gene expression. Cross‐species studies of Kaposi's sarcoma‐associated herpesvirus (KSHV), Epstein–Barr virus (EBV), and murine gamma herpesvirus 68 (MHV68)
Shekhar R, McMahon S, Tibbetts SA, Flemington EK, Renne R.   +4 more
europepmc   +2 more sources

EBV+ and Kaposi's Sarcoma Herpesvirus-Associated Multicentric Castleman Disease in a Patient With HIV Infection: A Case Report. [PDF]

Case Rep Infect Dis
Multicentric Castleman disease is a rare proliferative disease of lymphoid tissue. It has rarely been reported in Asian countries, particularly in HIV‐positive patients. Here, we report a case of Kaposi’s sarcoma herpesvirus‐associated Multicentric Castleman disease (KSHV‐MCD).
Huang MY, Li Z, Zhang W, Chen HY, Liu J, Li CX.   +5 more
europepmc   +2 more sources

The Role of Bacteria in KSHV Infection and KSHV-Induced Cancers [PDF]

Cancers, 2021
The objective of this article is to review the current status of the bacteria-virus interplay in Kaposi’s sarcoma-associated herpesvirus (KSHV) infection and KSHV-driven cancers. KSHV is the etiological agent of several cancers, including Kaposi’s sarcoma (KS) and primary effusion lymphoma.
Markazi, Ashley, Meng, Wen, Bracci, Paige M, McGrath, Michael S, Gao, Shou-Jiang   +4 more
openaire   +4 more sources

Spatial Transcriptomics of Patients With Kaposi Sarcoma Identifies Mechanisms of Immune Evasion. [PDF]

J Med Virol
ABSTRACT To identify the cell types that are infected with KSHV and the immune interactions in Kaposi sarcoma (KS) lesions, we performed spatial transcriptomics with seven KS skin tumors. We used a single‐cell RNA‐sequencing reference data set from healthy skin donors with a method to conduct spatially informed cell‐type deconvolution for spatial ...
Afsari B, Ramaswami R, Lurain K, Tagawa T, Knudsen-Palmer D, Mahesh G, Mungale A, Yarchoan R, Ziegelbauer J.   +8 more
europepmc   +2 more sources

Redefining KSHV Latency [PDF]

Cell Host & Microbe, 2013
In this issue of Cell Host & Microbe, Chang and Ganem (2013) report that Kaposi's sarcoma-associated herpesvirus infection of lymphatic endothelial cells (LECs), but not blood endothelial cells (BECs), activates mTORC1 signaling and sensitizes LECs to rapamycin-induced killing.
Yogev, Ohad, Boshoff, Chris
openaire   +2 more sources

KSHV LANA—The Master Regulator of KSHV Latency [PDF]

Viruses, 2014
Kaposi’s sarcoma associated herpesvirus (KSHV), like other human herpes viruses, establishes a biphasic life cycle referred to as dormant or latent, and productive or lytic phases. The latent phase is characterized by the persistence of viral episomes in a highly ordered chromatin structure and with the expression of a limited number of viral genes ...
Timsy Uppal, Sagarika Banerjee, Zhiguo Sun, Subhash Verma, Erle Robertson   +4 more
openaire   +4 more sources

Chromatinization of the KSHV Genome During the KSHV Life Cycle [PDF]

Cancers, 2015
Kaposi’s sarcoma-associated herpesvirus (KSHV) belongs to the gamma herpesvirus family and is the causative agent of various lymphoproliferative diseases in humans. KSHV, like other herpesviruses, establishes life-long latent infection with the expression of a limited number of viral genes.
Timsy Uppal, Hem Jha, Subhash Verma, Erle Robertson   +3 more
openaire   +3 more sources

KSHV: Immune Modulation and Immunotherapy [PDF]

Frontiers in Immunology, 2020
Kaposi's sarcoma (KS)-associated herpesvirus (KSHV) is associated with KS, primary effusion lymphoma (PEL), and multicentric Castleman disease (MCD). To ensure its own survival and propagation, KSHV employs an extensive network of viral proteins to subvert the host immune system, resulting in lifelong latent infection.
Grant Broussard, Grant Broussard, Blossom Damania, Blossom Damania, Blossom Damania   +4 more
openaire   +3 more sources

KSHV/HHV8‐associated lymphomas [PDF]

British Journal of Haematology, 2007
SummaryThis review looks at the current state of knowledge on primary effusion lymphoma (PEL) and other Kaposi sarcoma herpesvirus (KSHV)/human herpesvirus 8 (HHV8)‐associated lymphomas. In 1995, KSHV DNA sequences were identified within a distinct subgroup of acquired immunodeficiency syndrome‐related non‐Hodgkin lymphomas localized in body cavities ...
Antonino, Carbone, Annunziata, Gloghini
openaire   +2 more sources

Kaposi’s Sarcoma-Associated Herpesvirus (KSHV) LANA Prevents KSHV Episomes from Degradation

Journal of Virology, 2023
ABSTRACTProtein knock-down with an inducible degradation system is a powerful tool to study proteins of interest in living cells. Here, we adopted the auxin-inducible degron (AID) approach to detail Kaposi’s Sarcoma-associated herpesvirus (KSHV) latency-associated nuclear antigen (LANA) function in latency maintenance and inducible viral lytic gene ...
Ken-ichi Nakajima, Tomoki Inagaki, Jonna Magdallene Espera, Yoshihiro Izumiya   +3 more
openaire   +4 more sources