Results 11 to 20 of about 22,488 (214)
KSHV Genome Replication and Maintenance [PDF]
Frontiers in Microbiology, 2016 Kaposi’s sarcoma associated herpesvirus (KSHV) or human herpesvirus 8 (HHV8) is a major etiological agent for multiple severe malignancies in immunocompromised patients.
Namrata Gupta +4 more
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The Role of Bacteria in KSHV Infection and KSHV-Induced Cancers [PDF]
Cancers, 2021 The objective of this article is to review the current status of the bacteria-virus interplay in Kaposi’s sarcoma-associated herpesvirus (KSHV) infection and KSHV-driven cancers. KSHV is the etiological agent of several cancers, including Kaposi’s sarcoma (KS) and primary effusion lymphoma.
Markazi, Ashley +4 more
openaire +4 more sources
Cell Host & Microbe, 2013 In this issue of Cell Host & Microbe, Chang and Ganem (2013) report that Kaposi's sarcoma-associated herpesvirus infection of lymphatic endothelial cells (LECs), but not blood endothelial cells (BECs), activates mTORC1 signaling and sensitizes LECs to rapamycin-induced killing.
Yogev, Ohad, Boshoff, Chris
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KSHV LANA—The Master Regulator of KSHV Latency [PDF]
Viruses, 2014 Kaposi’s sarcoma associated herpesvirus (KSHV), like other human herpes viruses, establishes a biphasic life cycle referred to as dormant or latent, and productive or lytic phases. The latent phase is characterized by the persistence of viral episomes in a highly ordered chromatin structure and with the expression of a limited number of viral genes ...
Timsy Uppal +4 more
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Chromatinization of the KSHV Genome During the KSHV Life Cycle [PDF]
Cancers, 2015 Kaposi’s sarcoma-associated herpesvirus (KSHV) belongs to the gamma herpesvirus family and is the causative agent of various lymphoproliferative diseases in humans. KSHV, like other herpesviruses, establishes life-long latent infection with the expression of a limited number of viral genes.
Timsy Uppal +3 more
openaire +3 more sources
KSHV: Immune Modulation and Immunotherapy [PDF]
Frontiers in Immunology, 2020 Kaposi's sarcoma (KS)-associated herpesvirus (KSHV) is associated with KS, primary effusion lymphoma (PEL), and multicentric Castleman disease (MCD). To ensure its own survival and propagation, KSHV employs an extensive network of viral proteins to subvert the host immune system, resulting in lifelong latent infection.
Grant Broussard +4 more
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KSHV/HHV8‐associated lymphomas [PDF]
British Journal of Haematology, 2007 SummaryThis review looks at the current state of knowledge on primary effusion lymphoma (PEL) and other Kaposi sarcoma herpesvirus (KSHV)/human herpesvirus 8 (HHV8)‐associated lymphomas. In 1995, KSHV DNA sequences were identified within a distinct subgroup of acquired immunodeficiency syndrome‐related non‐Hodgkin lymphomas localized in body cavities ...
Antonino, Carbone, Annunziata, Gloghini
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Kaposi’s Sarcoma-Associated Herpesvirus (KSHV) LANA Prevents KSHV Episomes from Degradation
Journal of Virology, 2023 ABSTRACTProtein knock-down with an inducible degradation system is a powerful tool to study proteins of interest in living cells. Here, we adopted the auxin-inducible degron (AID) approach to detail Kaposi’s Sarcoma-associated herpesvirus (KSHV) latency-associated nuclear antigen (LANA) function in latency maintenance and inducible viral lytic gene ...
Ken-ichi Nakajima +3 more
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SUMO and KSHV Replication [PDF]
Cancers, 2014 Small Ubiquitin-related MOdifier (SUMO) modification was initially identified as a reversible post-translational modification that affects the regulation of diverse cellular processes, including signal transduction, protein trafficking, chromosome segregation, and DNA repair.
Chang, Pei-Ching, Kung, Hsing-Jien
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Blood Advances, 2023 Abstract Kaposi sarcoma–associated herpesvirus (KSHV)/human herpesvirus 8–associated multicentric Castleman disease (MCD) is a polyclonal B-cell lymphoproliferative disorder that mainly occurs in immunocompromised hosts. The diagnosis relies on lymph node biopsy demonstrating KSHV-infected cells located in the mantle zone with a marked ...
Martin de Frémont, Gregoire +23 more
openaire +2 more sources