Results 21 to 30 of about 24,542 (261)

SUMO and KSHV Replication [PDF]

Cancers, 2014
Small Ubiquitin-related MOdifier (SUMO) modification was initially identified as a reversible post-translational modification that affects the regulation of diverse cellular processes, including signal transduction, protein trafficking, chromosome segregation, and DNA repair.
Chang, Pei-Ching, Kung, Hsing-Jien
openaire   +2 more sources

Characteristics of circulating KSHV-infected viroblasts during active KSHV+ multicentric Castleman disease

Blood Advances, 2023
Abstract Kaposi sarcoma–associated herpesvirus (KSHV)/human herpesvirus 8–associated multicentric Castleman disease (MCD) is a polyclonal B-cell lymphoproliferative disorder that mainly occurs in immunocompromised hosts. The diagnosis relies on lymph node biopsy demonstrating KSHV-infected cells located in the mantle zone with a marked ...
Martin de Frémont, Gregoire, Vanjak, Anthony, Sbihi, Zineb, Knapp, Silene, Garzaro, Margaux, Chbihi, Marwa, Fournier, Benjamin, Poirot, Justine, Dossier, Antoine, Silvestrini, Marc-Antoine, Villemonteix, Juliette, Meignin, Véronique, Galicier, Lionel, Bertinchamp, Rémi, Le Goff, Jerome, Salmona, Maud, Flamarion, Edouard, Cassius, Charles, Lebbé, Celeste, Ronchetti, Anne Marie, Latour, Sylvain, Oksenhendler, Eric, Carcelain, Guislaine, Boutboul, David   +23 more
openaire   +2 more sources

Twenty Years of KSHV [PDF]

Viruses, 2014
Twenty years ago, Kaposi’s sarcoma (KS) was the oncologic counterpart to Winston Churchill’s Russia: a riddle, wrapped in a mystery, inside an enigma. First described by Moritz Kaposi in 1872, who reported it to be an aggressive skin tumor, KS became known over the next century as a slow-growing tumor of elderly men—in fact, most KS patients were ...
Chang, Y, Moore, P
openaire   +3 more sources

Latently KSHV-Infected Cells Promote Further Establishment of Latency upon Superinfection with KSHV [PDF]

International Journal of Molecular Sciences, 2021
Kaposi’s sarcoma-associated herpesvirus (KSHV) is a cancer-related virus which engages in two forms of infection: latent and lytic. Latent infection allows the virus to establish long-term persistent infection, whereas the lytic cycle is needed for the maintenance of the viral reservoir and for virus spread.
Chen Gam ze Letova, Inna Kalt, Meir Shamay, Ronit Sarid   +3 more
openaire   +2 more sources

KSHV Genome Replication and Maintenance [PDF]

Frontiers in Microbiology, 2016
Kaposi's sarcoma associated herpesvirus (KSHV) or human herpesvirus 8 (HHV8) is a major etiological agent for multiple severe malignancies in immune-compromised patients. KSHV establishes lifetime persistence in the infected individuals and displays two distinct life cycles, generally a prolonged passive latent, and a short productive or lytic cycle ...
Purushothaman, Pravinkumar, Dabral, Prerna, Gupta, Namrata, Sarkar, Roni, Verma, Subhash C.   +4 more
openaire   +4 more sources

Prevalence of Kaposi's sarcoma-associated herpesvirus and transfusion-transmissible infections in Tanzanian blood donors

International Journal of Infectious Diseases, 2020
Objective: Kaposi's sarcoma-associated herpesvirus (KSHV) is the causative agent for Kaposi's sarcoma (KS), one of the most common cancers in Tanzania. We have investigated KSHV prevalence and factors associated with KSHV infection in Tanzania.
Salum J. Lidenge, Tara Tran, For Yue Tso, John R. Ngowi, Danielle M. Shea, Julius Mwaiselage, Charles Wood, John T. West   +7 more
doaj   +1 more source

Reactive oxygen species hydrogen peroxide mediates Kaposi's sarcoma-associated herpesvirus reactivation from latency. [PDF]

PLoS Pathogens, 2011
Kaposi's sarcoma-associated herpesvirus (KSHV) establishes a latent infection in the host following an acute infection. Reactivation from latency contributes to the development of KSHV-induced malignancies, which include Kaposi's sarcoma (KS), the most ...
Fengchun Ye, Fuchun Zhou, Roble G Bedolla, Tiffany Jones, Xiufen Lei, Tao Kang, Moraima Guadalupe, Shou-Jiang Gao   +7 more
doaj   +1 more source

Biphasic euchromatin-to-heterochromatin transition on the KSHV genome following de novo infection. [PDF]

, 2013
The establishment of latency is an essential step for the life-long persistent infection and pathogenesis of Kaposi's sarcoma-associated herpesvirus (KSHV).
Brulois, Kevin, Izumiya, Yoshihiro, Jung, Jae U, Kung, Hsing-Jien, Lee, Hye-Ra, Tepper, Clifford, Toth, Zsolt   +6 more
core   +3 more sources

High-throughput sequencing analysis of a "hit and run" cell and animal model of KSHV tumorigenesis.

PLoS Pathogens, 2020
Kaposi's sarcoma (KS), is an AIDS-associated neoplasm caused by the KS herpesvirus (KSHV/ HHV-8). KSHV-induced sarcomagenesis is the consequence of oncogenic viral gene expression as well as host genetic and epigenetic alterations. Although KSHV is found
Julian Naipauer, Daria Salyakina, Guy Journo, Santas Rosario, Sion Williams, Martin Abba, Meir Shamay, Enrique A Mesri   +7 more
doaj   +1 more source

Establishment of Tree Shrew Animal Model for Kaposi’s Sarcoma-Associated Herpesvirus (HHV-8) Infection

Frontiers in Microbiology, 2021
Kaposi’s sarcoma-associated herpesvirus (KSHV) is the most common cause of Kaposi’s sarcoma (KS) and other malignant growths in humans. However, the lack of a KSHV-infected small animal model has hampered understanding of the mechanisms of KSHV infection,
Daoqun Li, Daoqun Li, Zulqarnain Baloch, Yang Zhao, Lei Bai, Xing Wang, Gang Wang, A-Mei Zhang, Ke Lan, Xueshan Xia   +9 more
doaj   +1 more source