Results 51 to 60 of about 16,928 (247)
Blood Advances, 2023 Abstract Kaposi sarcoma–associated herpesvirus (KSHV)/human herpesvirus 8–associated multicentric Castleman disease (MCD) is a polyclonal B-cell lymphoproliferative disorder that mainly occurs in immunocompromised hosts. The diagnosis relies on lymph node biopsy demonstrating KSHV-infected cells located in the mantle zone with a marked ...
Martin de Frémont, Gregoire +23 more
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Kaposi’s Sarcoma-Associated Herpesvirus and Host Interaction by the Complement System
Pathogens, 2020 Kaposi’s sarcoma-associated herpesvirus (KSHV) modulates the immune response to allow the virus to establish persistent infection in the host and facilitate the development of KSHV-associated cancer.
Seung-Min Yoo, Myung-Shin Lee
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Application of the CDK9 inhibitor FIT-039 for the treatment of KSHV-associated malignancy
BMC Cancer, 2023 Chronic infection with Kaposi’s sarcoma-associated herpes virus (KSHV) in B lymphocytes causes primary effusion lymphoma (PEL), the most aggressive form of KSHV-related cancer, which is resistant to conventional chemotherapy.
Tetsunori Sakamoto +5 more
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KSHV Induction of Angiogenic and Lymphangiogenic Phenotypes [PDF]
Frontiers in Microbiology, 2012 Kaposi's sarcoma (KS) is a highly vascularized tumor supporting large amounts of neo-angiogenesis. The major cell type in KS tumors is the spindle cell, a cell that expresses markers of lymphatic endothelium. KSHV, the etiologic agent of KS, is found in the spindle cells of all KS tumors.
Terri A. DiMaio, Michael Lagunoff
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Infectious Agents and Cancer, 2011 Background Kaposi sarcoma (KS) is the most common AIDS-defining tumour in HIV-infected individuals in Africa. Kaposi sarcoma herpes virus (KSHV) infection precedes development of KS.
Maskew Mhairi +5 more
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PLoS Pathogens, 2017 Kaposi sarcoma-associated herpesvirus (KSHV) causes several tumors and hyperproliferative disorders. Hypoxia and hypoxia-inducible factors (HIFs) activate latent and lytic KSHV genes, and several KSHV proteins increase the cellular levels of HIF.
Coralie Viollet +7 more
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Metabolic reprogramming of Kaposi's sarcoma associated herpes virus infected B-cells in hypoxia. [PDF]
PLoS Pathogens, 2018 Kaposi's sarcoma associated herpesvirus (KSHV) infection stabilizes hypoxia inducible factors (HIFs). The interaction between KSHV encoded factors and HIFs plays a critical role in KSHV latency, reactivation and associated disease phenotypes.
Rajnish Kumar Singh +4 more
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Nature Communications, 2018 The RIG-I like receptors (RLRs) RIG-I and MDA5 are cytosolic RNA helicases best characterized as restriction factors for RNA viruses. However, evidence suggests RLRs participate in innate immune recognition of other pathogens, including DNA viruses ...
Yang Zhao +4 more
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Virologica Sinica, 2019 Kaposi’s sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus-8 (HHV-8), is etiologically linked to the development of Kaposi’s sarcoma, primary effusion lymphoma, and multicentric Castleman’s disease.
Lijun Yan +3 more
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Frontiers in Microbiology, 2012 Soon after the discovery of Kaposi sarcoma (KS)-associated herpesvirus (KSHV), it was appreciated that this virus was associated with most cases of multicentric Castleman disease (MCD) arising in patients infected with human immunodeficiency virus.
Mark N. Polizzotto +3 more
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