Results 61 to 70 of about 22,488 (214)
G-quadruplexes and G-quadruplex ligands: targets and tools in antiviral therapy [PDF]
, 2018 G-quadruplexes (G4s) are non-canonical nucleic acids secondary structures that form within guanine-rich strands of regulatory genomic regions. G4s have been extensively described in the human genome, especially in telomeres and oncogene promoters; in ...
Richter, Sara N, Ruggiero, Emanuela
core +1 more source
Aging, 2015 Kaposi's sarcoma-associated herpesvirus (KSHV) is the causative agent of the endothelial cell-derived tumor Kaposi's sarcoma and of the lymphoproliferative disorders primary effusion lymphoma and multicentric Castleman's disease. The life cycle of KSHV includes a latent and a lytic/productive phase that both contribute to tumorigenic activity.
Vinay, Murtadak +2 more
openaire +2 more sources
Endoplasmic Reticulum-Shaping Atlastin Proteins Facilitate KSHV Replication
Frontiers in Cellular and Infection Microbiology, 2022 Kaposi’s sarcoma-associated herpesvirus (KSHV) has two life cycle modes: the latent and lytic phases. The endoplasmic reticulum (ER) is the site for KSHV production. Furthermore, ER stress can trigger reactivation of KSHV.
Wen-ying Long, Guo-hua Zhao, Yao Wu
doaj +1 more source
The Epstein-Barr Virus Episome Maneuvers between Nuclear Chromatin Compartments during Reactivation. [PDF]
, 2018 The human genome is structurally organized in three-dimensional space to facilitate functional partitioning of transcription. We learned that the latent episome of the human Epstein-Barr virus (EBV) preferentially associates with gene-poor chromosomes ...
Fernandez, Samantha G +7 more
core +1 more source
Infectious Agents and Cancer, 2010 Kaposi sarcoma-associated herpesvirus (KSHV, also called Human herpesvirus 8 or HHV8) is a γ-2 herpesvirus that causes Kaposi sarcoma. KSHV seroprevalence rates vary geographically with variable rates recorded in different sub Sahara African countries ...
Figueiredo Constança +11 more
doaj +1 more source
PLoS Pathogens, 2022 Polyamines are critical metabolites involved in various cellular processes and often dysregulated in cancers. Kaposi's sarcoma-associated Herpesvirus (KSHV), a defined human oncogenic virus, leads to profound alterations of host metabolic landscape to ...
Guillaume N Fiches +8 more
doaj +1 more source
HIV Medicine, EarlyView.Abstract Introduction A proportion of people living with HIV (PLWH) fail to restore their CD4 count or their CD4/CD8 ratio despite effective antiretroviral therapy (ART). PLWH with immune non‐response (INR) are at a higher risk of both AIDS and non‐AIDS events. The underlying mechanisms of INR remain unclear.
Charlotte Silvestre +2 more
wiley +1 more source
médecine/sciences, 2018 Le virus herpétique humain associé au sarcome de Kaposi (KSHV) est l’agent étiologique du lymphome primitif des séreuses (PEL) dans lequel le virus d’Epstein-Barr (EBV) est aussi très souvent présent. Jusqu’à présent, seuls des modèles cellulaires permettaient d’explorer l’interaction des deux virus conduisant à la transformation des cellules.
Henri Gruffat, Evelyne Manet
openaire +1 more source
Cytokine-Targeted Therapeutics for KSHV-Associated Disease
Viruses, 2020 Kaposi’s sarcoma-associated herpesvirus (KSHV) also known as human herpesvirus 8 (HHV-8), is linked to several human malignancies including Kaposi sarcoma (KS), primary effusion lymphoma (PEL), multicentric Castleman’s disease (MCD) and recently KSHV ...
Nedaa Alomari, Jennifer Totonchy
doaj +1 more source
A portable device for nucleic acid quantification powered by sunlight, a flame or electricity. [PDF]
, 2018 A decentralized approach to diagnostics can decrease the time to treatment of infectious diseases in resource-limited settings. Yet most modern diagnostic tools require stable electricity and are not portable.
Cesarman, Ethel +8 more
core +1 more source