Results 71 to 80 of about 16,928 (247)

Clinical Features and Outcomes of Patients With Symptomatic Kaposi Sarcoma Herpesvirus (KSHV)-associated Inflammation: Prospective Characterization of KSHV Inflammatory Cytokine Syndrome (KICS).

Clinical Infectious Diseases, 2016
BACKGROUND Kaposi sarcoma herpesvirus (KSHV) is the cause of Kaposi sarcoma (KS), primary effusion lymphoma (PEL), and a form of Castleman disease (KSHV-MCD).
M. Polizzotto, T. Uldrick, K. Wyvill, K. Aleman, V. Marshall, V. Wang, D. Whitby, S. Pittaluga, E. Jaffe, C. Millo, G. Tosato, R. Little, S. Steinberg, I. Sereti, R. Yarchoan   +14 more
semanticscholar   +1 more source

Human IFIT proteins inhibit lytic replication of KSHV: A new feed-forward loop in the innate immune system

PLoS Pathogens, 2019
Kaposi’s sarcoma-associated herpesvirus (KSHV) is causally associated with Kaposi’s sarcoma, primary effusion lymphoma (PEL) and multicentric Castleman’s disease. The IFIT family of proteins inhibits replication of some viruses, but their effects on KSHV
Dajiang Li, S. Swaminathan
semanticscholar   +1 more source

Advances in Single‐Cell Sequencing for Infectious Diseases: Progress and Perspectives

Advanced Science, EarlyView.
Single‐cell sequencing technologies uncover novel, unknown, and emergent features of many diseases. This review describes recent progress of single‐cell sequencing technologies and their applications in infectious diseases, summarizes the underlying commonalities of different infections and discusses future research directions, facilitating the ...
Mengyuan Lyu, Yang Liu, Jian Zhou, Hongli Lai, Hongxia Ruan, Dongsheng Wu, Shun Zhu, Xudong Zhou, Wananqi Ma, Yuchen Huang, Shuting Lei, Han Luo, Jie Chen, Binwu Ying   +13 more
wiley   +1 more source

Endoplasmic Reticulum-Shaping Atlastin Proteins Facilitate KSHV Replication

Frontiers in Cellular and Infection Microbiology, 2022
Kaposi’s sarcoma-associated herpesvirus (KSHV) has two life cycle modes: the latent and lytic phases. The endoplasmic reticulum (ER) is the site for KSHV production. Furthermore, ER stress can trigger reactivation of KSHV.
Wen-ying Long, Guo-hua Zhao, Yao Wu
doaj   +1 more source

Viral and Cellular N6-Methyladenosine (m6A) and N6, 2′-O-Dimethyladenosine (m6Am) Epitranscriptomes in KSHV Life Cycle

Nature Microbiology, 2017
N6-methyladenosine (m6A) and N6,2′-O-dimethyladenosine (m6Am) modifications (m6A/m) of messenger RNA mediate diverse cellular functions. Oncogenic Kaposi’s sarcoma-associated herpesvirus (KSHV) has latent and lytic replication phases that are essential ...
Brandon Tan, Hui Liu, Song-Seon Zhang, S. R. da Silva, Lin Zhang, Jia Meng, Xiaodong Cui, Hongfeng Yuan, O. Sorel, Shaowu Zhang, Yufei Huang, Shou-Jiang Gao   +11 more
semanticscholar   +1 more source

Mapping protein–protein interactions by mass spectrometry

Mass Spectrometry Reviews, EarlyView.
Abstract Protein–protein interactions (PPIs) are essential for numerous biological activities, including signal transduction, transcription control, and metabolism. They play a pivotal role in the organization and function of the proteome, and their perturbation is associated with various diseases, such as cancer, neurodegeneration, and infectious ...
Xiaonan Liu, Lawrence Abad, Lopamudra Chatterjee, Ileana M. Cristea, Markku Varjosalo   +4 more
wiley   +1 more source

Persistence of Kaposi Sarcoma–Associated Herpesvirus (KSHV)–Infected Cells in KSHV/HIV‐1–Coinfected Subjects without KSHV‐Associated Diseases [PDF]

The Journal of Infectious Diseases, 2005
Inguinal lymph nodes from 24 human immunodeficiency virus (HIV) type 1-infected subjects without Kaposi sarcoma-associated herpesvirus (KSHV)-associated diseases were examined for KSHV infection. KSHV-infected cells were detected at a very low frequency in the lymph nodes of 7 subjects (median frequency, 2 infected cells/10(7) lymph node cells). Latent,
Joy M. Folkvord, James M. Neid, Xing-Quan Zhang, Katherine Staskus, Elizabeth Connick, Irene E. White, Thomas B. Campbell   +6 more
openaire   +3 more sources

Transactivation of human endogenous retrovirus K (HERV-K) by KSHV promotes Kaposi’s Sarcoma development

Oncogene, 2018
Kaposi’s sarcoma-associated herpesvirus (KSHV) is the causative agent of several human cancers such as Kaposi’s sarcoma (KS), which represents the most common AIDS-associated malignancy that lacks effective treatment options.
L. Dai, L. Del Valle, W. Miley, D. Whitby, A. Ochoa, E. Flemington, Zhiqiang Qin   +6 more
semanticscholar   +1 more source

A Focus on Natural Autophagy Modulators as Potential Host‐Directed Weapons Against Emerging and Re‐Emerging Viruses

Medicinal Research Reviews, EarlyView.
ABSTRACT Autophagy is a highly conserved intracellular process involved in maintaining homeostasis and in the degradation of damaged organelles and external pathogens. Nature provides complex and varied reservoirs of scaffolds and chemical entities that may have a pivotal role in the search for new therapeutic leads.
Ilaria Cursaro, Sara Rossi, Stefania Butini, Sandra Gemma, Gabriele Carullo, Giuseppe Campiani   +5 more
wiley   +1 more source

KSHV Paracrine Effects on Tumorigenesis [PDF]

, 2012
In 1994, Chang and colleagues isolated two viral DNA fragments from Kaposi’s sarcoma (KS) patients which showed homologies to, but were distinct from, genes coding for capsid and tegument proteins of two herpesviruses namely, Epstein-Barr virus and Herpesvirus saimiri (Y. Chang et al., 1994).
Ramona Jochmann, Christian Zietz, Andreas Konrad, Michael Stürzl, Priya Chudasama, Peter Lorenz   +5 more
openaire   +3 more sources