Results 81 to 90 of about 16,928 (247)

Polyamine biosynthesis and eIF5A hypusination are modulated by the DNA tumor virus KSHV and promote KSHV viral infection.

PLoS Pathogens, 2022
Polyamines are critical metabolites involved in various cellular processes and often dysregulated in cancers. Kaposi's sarcoma-associated Herpesvirus (KSHV), a defined human oncogenic virus, leads to profound alterations of host metabolic landscape to ...
Guillaume N Fiches, Zhenyu Wu, Dawei Zhou, Ayan Biswas, Tai-Wei Li, Weili Kong, Maxime Jean, Netty G Santoso, Jian Zhu   +8 more
doaj   +1 more source

EBV and KSHV Infection Dysregulates Autophagy to Optimize Viral Replication, Prevent Immune Recognition and Promote Tumorigenesis

Viruses, 2018
Autophagy is a catabolic process strongly involved in the immune response, and its dysregulation contributes to the onset of several diseases including cancer.
M. Cirone
semanticscholar   +1 more source

Lactate and Lactylation in AKI‐to‐CKD: Epigenetic Regulation and Therapeutic Opportunities

Cell Proliferation, EarlyView.
ABSTRACT Lactate is not only a byproduct of glycolysis, but is also considered an energy source, gluconeogenic precursor, signalling molecule and protein modifier during the process of cellular metabolism. The discovery of lactylation reveals the multifaceted functions of lactate in cellular metabolism and opens new avenues for lactate‐related research.
Yi Hou, Dongwei Liu, Zuishuang Guo, Cien Wei, Fengyu Cao, Yue Xu, Qi Feng, Fengxun Liu   +7 more
wiley   +1 more source

Identification of new antiviral agents against Kaposi’s sarcoma-associated herpesvirus (KSHV) by high-throughput drug screening reveals the role of histamine-related signaling in promoting viral lytic reactivation

PLoS Pathogens, 2019
Kaposi’s sarcoma-associated herpesvirus (KSHV) causes several human cancers, such as Kaposi’s sarcoma (KS) and primary effusion lymphoma (PEL). Current treatment options for KSHV infection and virus associated diseases are sometimes ineffective ...
Jungang Chen, L. Dai, Alana Goldstein, Haiwei Zhang, Wei-Feng Tang, J. Craig Forrest, Steven R. Post, Xulin Chen, Zhiqiang Qin   +8 more
semanticscholar   +1 more source

A guide to heat shock factors as multifunctional transcriptional regulators

The FEBS Journal, EarlyView.
The heat shock factors (HSFs) are evolutionarily conserved transcription factors best known as regulators of molecular chaperone genes in response to heat shock and other protein‐damaging stresses. Vertebrate HSFs, HSF1‐5, HSFX, and HSFY, are implicated in various physiological and pathological processes, including organismal development and cancer ...
Hendrik S. E. Hästbacka, Alejandro J. Da Silva, Lea Sistonen, Eva Henriksson   +3 more
wiley   +1 more source

KSHV and the toll of innate immune activation [PDF]

Cell Cycle, 2009
Comment on: Gregory SM, West JA, Dillon PJ, Hilscher C, Dittmer DP, Damania B. Toll-like receptor signaling controls reactivation of KSHV from latency. Proc Natl Acad Sci USA 2009; 106:11725-30.
Sean M. Gregory, Blossom Damania
openaire   +3 more sources

Herpesvirus Simplex Virus‐1 Exploits Inflammation to Infect Periodontal Stem Cells and Disrupt Lineage Commitment

Journal of Periodontal Research, EarlyView.
HSV‐1 infects oral mesenchymal stem cells both in vitro and in vivo to dysregulate their lineage commitment. An inflamed gingival environment increases susceptibility to HSV‐1 infection, which further elevates proinflammatory cytokine levels and exacerbates alveolar bone loss.
Araceli Valverde, Raza Ali Naqvi, Yinghua Chen, Alireza Moshaverinia, Anne George, Deepak Shukla, Gloria Martinez, Gabriella Chapa, Salvador Nares, Afsar R. Naqvi   +9 more
wiley   +1 more source

PDGFRA defines the mesenchymal stem cell Kaposi’s sarcoma progenitors by enabling KSHV oncogenesis in an angiogenic environment

bioRxiv, 2019
Kaposi’s sarcoma (KS) is an AIDS-defining cancer caused by the KS-associated herpesvirus (KSHV). Unanswered questions regarding KS are its cellular ontology and the conditions conducive to viral oncogenesis.
J. Naipauer, Santas Rosario, Sachin Gupta, C. Premer, Omayra Méndez-Solís, Mariana Schlesinger, Virginia Ponzinibbio, Vaibhav Jain, Lauren A. Gay, R. Renne, Ho Lam Chan, L. Morey, D. Salyakina, M. Abba, Sion L. Williams, J. Hare, P. Goldschmidt-Clermont, E. Mesri   +17 more
semanticscholar   +1 more source

Heterogeneous Activation of Signaling Pathways and Therapeutic Vulnerabilities in KSHV‐Associated Primary Effusion Lymphoma Cell Lines

Journal of Medical Virology, Volume 97, Issue 8, August 2025.
ABSTRACT Primary effusion lymphoma (PEL) is a rare and aggressive B‐cell malignancy caused by Kaposi's sarcoma‐associated herpesvirus (KSHV), with limited treatment options and poor prognosis. KSHV‐encoded proteins and miRNAs activate multiple signaling pathways that promote cell proliferation and survival.
Lianna Huang, Luping Chen, Yufei Huang, Shou‐Jiang Gao   +3 more
wiley   +1 more source

Quantitative Analysis of Kaposi Sarcoma–Associated Herpesvirus (KSHV) in KSHV‐Associated Diseases [PDF]

The Journal of Infectious Diseases, 2006
Accurate numbers of copies of Kaposi sarcoma-associated herpesvirus (KSHV) and numbers of virus-infected cells in lesions caused by KSHV-associated diseases are unknown.Quantitative polymerase chain reaction (PCR) and computerized imaging of immunohistochemical analysis were performed on pathologic sections of samples from persons with KSHV-associated ...
Yuko Sato, Tetsutaro Sata, Harutaka Katano, Takayuki Kanno, Yasuko Asahi-Ozaki   +4 more
openaire   +2 more sources