Results 81 to 90 of about 24,542 (261)

Disease Progression Mediated by Egr-1 Associated Signaling in Response to Oxidative Stress [PDF]

, 2012
When cellular reducing enzymes fail to shield the cell from increased amounts of reactive oxygen species (ROS), oxidative stress arises. The redox state is misbalanced, DNA and proteins are damaged and cellular transcription networks are activated.
Abdulkadir, Abdulkadir, Aggeli, Arsenian, Banks, Baron, Bedadala, Bedard, Bjelakovic, Bjelakovic, Bonventre, Brand, Calogero, Cao, Cao, Chang, Chen, Christy, Christy, Cramer, Datta, Dixit, Dixit, Dyson, Dyson, Eidelman, Elisabeth Deindl, Eto, Eto, Fahmy, Fahmy, Feldman, Forsberg, Förstermann, Gao, Gashler, Hallahan, Halliwell, Harja, Harman, Harrison, Hasan, Hasan, Hebert, Heo, Hill, Hirata, Huang, Irani, Iyoda, Izumi, Judith-Irina Pagel, Katsarou, Kawamura, Khachigian, Khachigian, Konishi, Lee, Liao, Lim, Lukac, Marais, Meira, Nishi, Nose, Nose, Nozik-Grayck, Ohba, Ouellette, Pagel, Paron, Pavletich, Peskin, Pines, Preston, Radisky, Sakamoto, Sattler, Schwachtgen, Sies, Sies, Stuart, Sudenga, Tell, Tell, Tell, Tell, Terashima, Treisman, Tsai-Morris, Vickers, Vivekananthan, Wang, Whitmarsh, Yan, Yan, Yang, Yang, Ye, Yu   +99 more
core   +2 more sources

Harnessing viral footprints in circulating free DNA (cfDNA) for early cancer detection: A focus on liquid‐biopsy‐based screening

International Journal of Cancer, Volume 158, Issue 3, Page 511-526, 1 February 2026.
Abstract Viral infections play a significant role in cancer development, making detecting viral signatures a promising approach for early cancer diagnosis. Circulating free DNA (cfDNA), released into the bloodstream by tumors and other cells, has emerged as a powerful biomarker for non‐invasive cancer screening.
Richard Donkor Amponsah, Emmanuel Addai Gyabaah, Moro Amidu, Zhao Cheng, Fazlur Rahman Talukdar   +4 more
wiley   +1 more source

Trends in Kaposi's sarcoma-associated Herpesvirus antibodies prior to the development of HIV-associated Kaposi's sarcoma: a nested case-control study. [PDF]

, 2014
HIV-associated Kaposi's sarcoma (KS) is a public health challenge in sub-Saharan Africa since both the causative agent, Kaposi's sarcoma associated-herpesvirus (KSHV), and the major risk factor, HIV, are prevalent. In a nested case-control study within a
Elliott, Alison M, Johnston, W Thomas, Mayanja, Billy N, Miley, Wendell, Nalwoga, Angela, Newton, Robert, Wakeham, Katie, Webb, Emily L, Whitby, Denise   +8 more
core   +1 more source

Blocking Lysine Crotonylation and Aerobic Glycolysis as Targeting Strategy Against mpox Virus Replication

Advanced Science, Volume 13, Issue 4, 19 January 2026.
Wei et al. report that MPXV infection induces aerobic glycolysis, a process mediated by the viral protein I3 through lysine crotonylation at its K102 residue. The acetyltransferase MYST1 catalyzes the crotonylation of I3 to inhibit the ubiquitin‐mediated degradation of WDR26.
Pengjun Wei, Zongzheng Zhao, Ruoqi Xu, Qin Yan, Liangzi Jiang, Fuxiao Geng, Yang Gu, Tianjiao Wang, Jing Zhou, Xiao Li, Qin Yan, Chun Lu, Wan Li   +12 more
wiley   +1 more source

The Inflammatory Kinase MAP4K4 Promotes Reactivation of Kaposi's Sarcoma Herpesvirus and Enhances the Invasiveness of Infected Endothelial Cells [PDF]

, 2013
Kaposi's sarcoma (KS) is a mesenchymal tumour, which is caused by Kaposi's sarcoma herpesvirus (KSHV) and develops under inflammatory conditions. KSHV-infected endothelial spindle cells, the neoplastic cells in KS, show increased invasiveness, attributed
A Beeghly-Fadiel, A Cuenda, A Greenhough, A Grundhoff, A Jarviluoma, A Kitzis, A Liacini, A Sodhi, AE Carpenter, AM Manning, AW Liu, B Ensoli, B Fingleton, BD Shelby, Blossom Damania, BW Ozanne, C Grossmann, C Yan, CJ Edgell, CS Collins, D Blankaert, D Briot, D Ganem, D Ganem, D Qin, D Rott, Darya A. Haas, DF Legler, DH Kedes, DL Simmons, DM Lukac, E Deutsch, EA Jaffe, EI Deryugina, F Cheng, F Cheng, F Lu, FA Mack, FQ Wang, G Giraldo, GJ Tesz, Guntram Büsche, György Keri, H Chang, H Katano, H Lu, H Nagase, H Pan, H Sheng, H Zhu, HJ Ra, I Nindl, J An, J Nicholas, J Soulier, J Vieira, J Westermarck, J Xie, J Xie, JA Mengshol, JC Boehm, JC Lee, JC Lee, Jessica Rückert, JG Kang, JJ Liang, JL Ambrus, JN Kline, JN Martin, JR Jackson, JW Said, JW Tjiu, K Bouzakri, K Lan, K Wisithphrom, Kiran Bala, KJ Sales, KQ Hu, KR Alkharsah, KV Guntur, L Pantanowitz, L Rosano, LC Meade-Tollin, LW Qian, M Aouadi, M Baumgartner, M Chatterjee, M Khyatti, M Paulose-Murphy, M Pouliot, M Rincon, M Tsujii, MA Fabian, Magdalena Weidner-Glunde, ME Janelle, MH Qiu, Michael Kracht, MM Brinkmann, Modester Damas, MR Bongiorno, MW Karaman, N Dupin, N Edraki, N Otsu, N Sharma-Walia, N Sharma-Walia, N Yamamoto, Oliver Dittrich-Breiholz, P Ben-Av, P Pyakurel, PJ Dillon, PP Naranatt, PP Naranatt, PS Moore, PW Ford, R Ala-Aho, RE Harris, RW Humphrey, S Kati, S Milligan, S Sadagopan, Semra Kati, Silvia Gramolelli, SJ Gao, SK Lee, SM Gregory, Susann Santag, SX Han, T Fournier, T Gatanaga, T May, T Shiomi, T Simonart, TB Campbell, TF Gallagher, TF Schulz, Thomas F. Schulz, TL Symensma, UR Hengge, UR Hengge, V Fonsato, V Knauper, V Puri, W Greene, W Yue, WW Au, X Tang, Y Chang, Y Liang, Y Xu, YH Chung, Z Yao, Zoltan Varga   +152 more
core   +1 more source

RNAi Regulator C3PO Promotes Arbovirus Infection in Insect Vectors

Advanced Science, Volume 13, Issue 4, 19 January 2026.
RNA interference (RNAi) is vital for eukaryotes to defend against virus infection. The C3PO complex takes part in RNAi but its role in regulating viral infection remains unclear. This work finds that insect C3PO facilitates arbovirus replication by degrading precursors of miRNAs, especially miR‐971‐3p.
Yan Xiao, Tianyu Guan, Qianfeng Xia, Chen Chen, Qian Wang, Lan Luo, Hong Lu, Feng Cui   +7 more
wiley   +1 more source

Toward Anti‐Herpesviral PROTACs: Assessing the Challenges for Targeted Protein Degradation on the Example of Kaposi's Sarcoma‐Associated Herpesvirus Latency‐Associated Nuclear Antigen

ChemMedChem, Volume 21, Issue 1, January 2026.
It is attempted to employ proteolysis‐targeting chimeras‐based targeted protein degradation to the viral protein “Latency‐associated Nuclear Antigen” from Kaposi's sarcoma‐associated herpesvirus. While ternary complex formation is detected via native mass spectrometry, protein degradation is not observed, presumably due to insufficient permeability ...
Aylin Berwanger, Saskia Catherina Stein, Sarah Brandner, Andreas Martin Kany, Sebastian Heinz, Brigitta Loretz, Claus‐Michael Lehr, Anna Katharina Herta Hirsch, Frederik Lermyte, Thomas Friedrich Schulz, Martin Empting   +10 more
wiley   +1 more source

Upregulation of xCT by KSHV-encoded microRNAs facilitates KSHV dissemination and persistence in an environment of oxidative stress. [PDF]

PLoS Pathogens, 2010
Upregulation of xCT, the inducible subunit of a membrane-bound amino acid transporter, replenishes intracellular glutathione stores to maintain cell viability in an environment of oxidative stress.
Zhiqiang Qin, Eduardo Freitas, Roger Sullivan, Sarumathi Mohan, Rocky Bacelieri, Drake Branch, Margaret Romano, Patricia Kearney, Jim Oates, Karlie Plaisance, Rolf Renne, Johnan Kaleeba, Chris Parsons   +12 more
doaj   +1 more source

Age of Infection with Kaposi Sarcoma-Associated Herpesvirus and Subsequent Antibody Values Among Children in Uganda. [PDF]

, 2018
We investigated associations between Kaposi sarcoma-associated herpesvirus (KSHV) seroconversion age and KSHV antibody values in Ugandan children. Every annual delay in KSHV seroconversion age was associated with a reduction of 19% (P < 0.0001) in K8.1 ...
Cose, Stephen, Elliott, Alison, Labo, Nazzarena, Miley, Wendell, Nalwoga, Angela, Newton, Robert, Whitby, Denise   +6 more
core   +1 more source

The CD8 and CD4 T-cell response against Kaposi's sarcoma-associated herpesvirus is skewed towards early and late lytic antigens.

PLoS ONE, 2009
Kaposi's sarcoma-associated herpesvirus (KSHV) is causally related to Kaposi's sarcoma (KS), the most common malignancy in untreated individuals with HIV/AIDS. The adaptive T-cell immune response against KSHV has not been fully characterized.
Rebecca C Robey, Dimitrios Lagos, Fiona Gratrix, Stephen Henderson, Nick C Matthews, Richard J Vart, Mark Bower, Chris Boshoff, Frances M Gotch   +8 more
doaj   +1 more source