Results 111 to 120 of about 42,072 (228)

Targeting the LPI/GPR55 Axis in MAFLD and MASH: Novel Insights, Therapeutic Strategies and Future Directions

Liver International, Volume 46, Issue 4, April 2026.
ABSTRACT Metabolic dysfunction‐associated fatty liver disease (MAFLD), recently redefined from non‐alcoholic fatty liver disease (NAFLD), highlights the central role of metabolic dysfunction in its pathophysiology. The L‐α‐lysophosphatidylinositol/G protein‐coupled receptor 55 (LPI/GPR55) axis, an element of the endocannabinoidome, has emerged as a key
Jerome Lian, Ricky R Lareu, Mohan Patil, Marco Falasca   +3 more
wiley   +1 more source

Induction of TFEB promotes Kupffer cell survival and reduces lipid accumulation in MASLD. [PDF]

Hepatol Commun
Chan MM, Daemen S, Beatty W, Byrnes K, Cho K, Ferguson D, Feldstein N, Park C, Guo Z, Park AC, Fu CF, Florczak KL, He L, Yang BQ, Javaheri A, Patti GJ, Finck BN, Razani B, Schilling JD.   +18 more
europepmc   +1 more source

The Gut‐Liver Axis in Metabolic Dysfunction‐Associated Steatotic Liver Disease: From Mechanistic Insights to Precision Therapeutics

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
Description: This review synthesizes groundbreaking advances in the gut‐liver axis for MASLD management. It details mechanistic pathways from transkingdom dysbiosis to liver pathology, integrating AI‐driven diagnostics and host genetics (PNPLA3). The framework transitions from broad microbial restoration to precision medicine, showcasing targeted ...
Shaoliang Zhu, Mengjie Zou, Qijun Wu, Yan Zou, Tingting Tan, Zhangnan Huang, Zheng Gong, Honglin Luo, Xiaofeng Dong   +8 more
wiley   +1 more source

Targeting Kupffer Cell Enolase 1 Attenuates Liver Inflammation and Injury in Hemorrhagic Shock. [PDF]

Int J Mol Sci
Hu Z, Li J, Rashid N, Jacob A, Wang P.
europepmc   +1 more source

Single Cell Analysis Reveals the Presence of Novel Intermediate Cells in Both Mice and Patients With Severe MASLD

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
Schematic overview of the experimental workflow combining single‐cell RNA sequencing and spatial proteomics in a murine model of MASLD. Tissues were isolated, dissociated, and processed for single‐cell transcriptomic profiling to identify distinct cellular clusters and define cell‐type–specific gene expression signatures. Computational analysis enabled
Marica Meroni, Paride Pelucchi, Erika Paolini, Miriam Longo, Ada Sula, Michele Battistin, Alice Chiodi, Deborah Mattinzoli, Masami Ikehata, Elena Trombetta, Daniele Dondossola, Alessandra Mezzelani, Gianluca Martino Tartaglia, Giuseppe Castellano, Anna Ludovica Fracanzani, Flora Peyvandi, Stefano Gatti, Ettore Mosca, Paola Dongiovanni   +18 more
wiley   +1 more source

Kupffer Cell-Derived Interleukin-6 Aggravates Radiation-Induced Liver Disease by Activating Hepatocyte STAT3 to Promote <i>Ccng1</i> Transcription. [PDF]

Adv Radiat Oncol
Song X, Shao Y, Sun R, Jiang W, Chen Y, Liu M, Gu W, Zheng X, Jiang J.   +8 more
europepmc   +1 more source

Effect of Interferon Gamma on Ebola Virus Infection of Primary Kupffer Cells and a Kupffer Cell Line. [PDF]

Viruses, 2023
Aguilar-Briseño JA, Elliff JM, Patten JJ, Wilson LR, Davey RA, Bailey AL, Maury WJ.   +6 more
europepmc   +1 more source

Export of miRNAs from activated macrophages is cooperative and HuR‐dependent

FEBS Letters, Volume 600, Issue 5, Page 693-709, March 2026.
This study uncovers a new mechanism for miRNA export regulation in mammalian cells, driven by the RNA‐binding protein HuR. In macrophages, HuR cooperatively binds with miRNAs to export both low‐ and high‐affinity substrates, thereby influencing macrophage activation.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Discrimination of cell-intrinsic and environment-dependent effects of natural genetic variation on Kupffer cell epigenomes and transcriptomes. [PDF]

Nat Immunol, 2023
Bennett H, Troutman TD, Zhou E, Spann NJ, Link VM, Seidman JS, Nickl CK, Abe Y, Sakai M, Pasillas MP, Marlman JM, Guzman C, Hosseini M, Schnabl B, Glass CK.   +14 more
europepmc   +1 more source

Kupffer Cell [PDF]

, 2020
openaire   +1 more source