Results 121 to 130 of about 43,811 (246)

The depletion of serine beta‐lactamase‐like protein (LACTB) ameliorates metabolic dysfunction–associated steatotic liver disease by reducing ubiquitin‐mediated degradation of carnitine palmitoyltransferase 2

Diabetes, Obesity and Metabolism, Volume 28, Issue 4, Page 2962-2977, April 2026.
Abstract Aims Metabolic dysfunction–associated steatotic liver disease (MASLD) represents one of the most common chronic liver disorders worldwide, and its incidence continues to rise each year. Serine β‐lactamase‐like protein (LACTB) is a serine protease that plays a crucial role in lipid metabolism and hepatocellular carcinoma, but its function in ...
Wujiang Shi, Xin Liu, Nan Wang, Qianwen Zhang, Jianjun Gao, Canghai Guan, Yapeng Li, Chengru Yang, Shaowu Bi, Xinlei Zou, Xiangyu Zhong   +10 more
wiley   +1 more source

The Role of Kupffer Cells and Liver Macrophages in the Pathogenesis of Metabolic Dysfunction-Associated Steatotic Liver Disease. [PDF]

Biomedicines
Tsomidis I, Tsakou A, Voumvouraki A, Kouroumalis E.   +3 more
europepmc   +1 more source

Targeting the LPI/GPR55 Axis in MAFLD and MASH: Novel Insights, Therapeutic Strategies and Future Directions

Liver International, Volume 46, Issue 4, April 2026.
ABSTRACT Metabolic dysfunction‐associated fatty liver disease (MAFLD), recently redefined from non‐alcoholic fatty liver disease (NAFLD), highlights the central role of metabolic dysfunction in its pathophysiology. The L‐α‐lysophosphatidylinositol/G protein‐coupled receptor 55 (LPI/GPR55) axis, an element of the endocannabinoidome, has emerged as a key
Jerome Lian, Ricky R Lareu, Mohan Patil, Marco Falasca   +3 more
wiley   +1 more source

Protocol for generating liver organoids containing Kupffer cells using human iPSCs. [PDF]

STAR Protoc
Li Y, Nie Y, Taniguchi H.
europepmc   +1 more source

The Gut‐Liver Axis in Metabolic Dysfunction‐Associated Steatotic Liver Disease: From Mechanistic Insights to Precision Therapeutics

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
Description: This review synthesizes groundbreaking advances in the gut‐liver axis for MASLD management. It details mechanistic pathways from transkingdom dysbiosis to liver pathology, integrating AI‐driven diagnostics and host genetics (PNPLA3). The framework transitions from broad microbial restoration to precision medicine, showcasing targeted ...
Shaoliang Zhu, Mengjie Zou, Qijun Wu, Yan Zou, Tingting Tan, Zhangnan Huang, Zheng Gong, Honglin Luo, Xiaofeng Dong   +8 more
wiley   +1 more source

Preoperative exercise induces anti-tumor Kupffer cells to prevent surgical stress-promoted colorectal cancer liver metastasis. [PDF]

Cell Rep Med
Zhang Y, Zhang Y, Shen C, Li J, Wang H, Hamad A, Cao C, El Moheb M, Wang Y, Xia Y, Cummins KC, Beane J, Ejaz A, Huang H, Tsung A, Zhang H.   +15 more
europepmc   +1 more source

Single Cell Analysis Reveals the Presence of Novel Intermediate Cells in Both Mice and Patients With Severe MASLD

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
Schematic overview of the experimental workflow combining single‐cell RNA sequencing and spatial proteomics in a murine model of MASLD. Tissues were isolated, dissociated, and processed for single‐cell transcriptomic profiling to identify distinct cellular clusters and define cell‐type–specific gene expression signatures. Computational analysis enabled
Marica Meroni, Paride Pelucchi, Erika Paolini, Miriam Longo, Ada Sula, Michele Battistin, Alice Chiodi, Deborah Mattinzoli, Masami Ikehata, Elena Trombetta, Daniele Dondossola, Alessandra Mezzelani, Gianluca Martino Tartaglia, Giuseppe Castellano, Anna Ludovica Fracanzani, Flora Peyvandi, Stefano Gatti, Ettore Mosca, Paola Dongiovanni   +18 more
wiley   +1 more source

DTX1-mediated degradation of TUBB3 in Kupffer cells mitigates hepatocellular carcinoma progression by regulating M1/M2 polarization. [PDF]

Commun Biol
Sun J, Sun T, Zhang Y, Liu B, Yin L.
europepmc   +1 more source

Export of miRNAs from activated macrophages is cooperative and HuR‐dependent

FEBS Letters, Volume 600, Issue 5, Page 693-709, March 2026.
This study uncovers a new mechanism for miRNA export regulation in mammalian cells, driven by the RNA‐binding protein HuR. In macrophages, HuR cooperatively binds with miRNAs to export both low‐ and high‐affinity substrates, thereby influencing macrophage activation.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Alpha-Lipoic Acid Reduces NLRP3/ASC Expression and IL-1β Release in Kupffer Cells and Improves Insulin Signaling in FL83B Hepatocytes Exposed to a Conditioned Medium. [PDF]

Food Sci Nutr
Ko CY, Lo YM, Nguyen TKN, Kao ST, Wu CH, Huang WC, Shen SC.   +6 more
europepmc   +1 more source