Results 151 to 160 of about 43,811 (246)

Association Between Dietary Tea Consumption and Non‐Alcoholic Fatty Liver Disease: A Systematic Review and Meta‐Analysis

Health Science Reports, Volume 9, Issue 3, March 2026.
ABSTRACT Background Non‐Alcoholic Fatty Liver Disease (NAFLD) is a significant global health concern linked with metabolic syndrome, affecting approximately 25% of the global population. It leads to severe liver complications and has limited effective pharmacological treatments. Tea, known for its bioactive compounds such as flavonoids and polyphenols,
Amogh Verma, Ranjana Sah, Rachana Mehta
wiley   +1 more source

Binge drinking triggers VGLUT3-mediated glutamate secretion and subsequent hepatic inflammation by activating mGluR5/NOX2 in Kupffer cells. [PDF]

Nat Commun
Yang K, Kim K, Ryu T, Shim YR, Kim HH, Choi SE, Kim MJ, Chung KPS, Lee E, Lee KW, Jeon J, Kim P, Kim YS, Ku T, Jeong H, Nam KT, Lim G, Choi DW, Kim SH, Eun HS, Kim W, Jeong WI.   +21 more
europepmc   +1 more source

Diagnostic Value of Neutrophil CD64 in Differentiating Scrub Typhus From Febrile Diseases

Immunity, Inflammation and Disease, Volume 14, Issue 3, March 2026.
ABSTRACT Background Scrub typhus, lacks specific early symptoms, and traditional serological tests have low sensitivity. This study shows that CD64 has superior diagnostic performance compared to CRP and PCT in bacterial infections. Methods This retrospective study analyzed 242 febrile patients admitted to the Jiangsu Province (Suqian) Hospital ...
Jing Su, Junyi Chen, Xuan Shen, Yaoyun Zhang, Wenya Li, Jijin Qi, Qing Zhong, Tianyu Sun, Siqi Shi, Fang Zhu, Youde Yan   +10 more
wiley   +1 more source

[Role of Kupffer cells in liver regeneration with metabolic associated fatty liver disease in mice]. [PDF]

Zhonghua Gan Zang Bing Za Zhi
Wang TW, Liu L, Wang SY, Cheng LL, Wang X, Cao YN, Wang YF, Yang LM.   +7 more
europepmc   +1 more source

Imidazole Alkaloids Epiisopilosine and Epiisopiloturine Attenuate Acetaminophen‐Induced Liver Toxicity in Mice via Autophagy Modulation and Anti‐Inflammatory Effects

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 3, March 2026.
Imidazole alkaloids epiisopilosine and epiisopiloturine protect the liver against acetaminophen‐induced toxicity by reducing oxidative stress, suppressing inflammatory mediators, and restoring antioxidant defenses. These hepatoprotective effects are partially mediated by enhanced autophagy, indicating a key mechanistic pathway for the biological ...
Ana Patricia de Oliveira, Gabriella Pacheco, André Luis Fernandes Lopes, Andreza Ketly da Silva Araujo, Letícia de Sousa Chaves, Simone de Araújo, Erick Bryan de Sousa Lima, Even Herlany Pereira Alves, Celso Martins Queiroz‐Junior, Mauro Martins Teixeira, Vivian Vasconcelos Costa, Jéssica Maria Teles Souza, Ayslan Batista Barros, Paulo Sérgio de Araujo Sousa, Jefferson Almeida Rocha, Ana Jérsia Araújo, José Delano Barreto Marinho Filho, Leiz Maria Costa Véras, Daniel Fernando Pereira Vasconcelos, Jand Venes Rolim Medeiros   +19 more
wiley   +1 more source

Breast cancer induces CD62L⁺ Kupffer cells via DMBT1 to promote neutrophil extracellular trap formation and liver metastasis. [PDF]

Cell Discov
Tian P, Wu Q, He D, Zhao W, Luo L, Jia Z, Luo W, Lv X, Liu Y, Wang Y, Wang Q, Zhang P, Liang Y, Yang Q, Hu G.   +14 more
europepmc   +1 more source

An Exploratory Study on the Pathogenic Role of Faecal Extracellular Vesicles in Metabolic Dysfunction‐Associated Steatotic Liver Disease Progression and in Drug‐Induced Liver Injury

Journal of Extracellular Vesicles, Volume 15, Issue 3, March 2026.
Fecal extracellular vesicles (fEVs) from DILI patients have a distinct bacterial profile. This study provides evidence that bacterial EVs enter the bloodstream. DILI and MASLD F≥3 fEVs increase the pro‐inflammatory response and hepatocyte steatosis. FEVs from DILI patients enhance the hepatotoxic potential of diclofenac.
Antonio J. Ruiz‐Malagón, Marina Herraiz‐Vilela, Jose Pinazo‐Bandera, Juan Pedro Toro‐Ortiz, Carlos López‐Gómez, Ailec Ho‐Plagaro, Lourdes Garrido‐Sánchez, Mercedes Robles‐Díaz, Bernard Taminiau, Georges Daube, Judith Sanabria‐Cabrera, Gonzalo Matilla‐Cabello, Maria Isabel Lucena, Raúl J. Andrade, Eduardo García‐Fuentes, Miren García‐Cortes, Cristina Rodriguez‐Diaz   +16 more
wiley   +1 more source

A1AT dysregulation of metabolically stressed hepatocytes by Kupffer cells drives MASH and fibrosis. [PDF]

Exp Mol Med
Park JS, Lee J, Wang F, Ma H, Zhou Z, Lee YS, Oh K, Lee H, Sui G, Lee S, Yang YM, Lee JW, Ji YH, Park CW, Yoo HS, Hwang BY, Han SB, Song N, Oh S, Kim B, Seki E, Hong JT, Roh YS.   +22 more
europepmc   +1 more source

Companion Diagnostics in Clinical Therapy: Current Applications and Future Directions

MedComm, Volume 7, Issue 3, March 2026.
Companion diagnostics use biomarker‐based assays to stratify patients for precision therapies, improving outcomes while reducing ineffective treatment and side effects. This review summarizes the evolution, regulatory landscape, clinical applications, and technological platforms of CDx, highlighting their role in biomarker‐driven precision therapy.
Yuesong Wu, Rou Xue, Xiangwen Luo, Jiangnan Liao, Zongbo Zhang, Jinhai Deng, Teng Liu, Xin Li, Zhe‐Sheng Chen, Mingzhu Yin   +9 more
wiley   +1 more source

The role of Kupffer cells in microbiota-brain communication: Sleep and fever signaling in response to lipopolysaccharide. [PDF]

Brain Behav Immun
Szentirmai É, Buckley K, Kapás L.
europepmc   +1 more source