Results 111 to 120 of about 3,560 (160)

Discovery of Novel Bicyclic Pyrazole Amides as Potent Neuronal K_V7 Potassium Channel Openers with Strong Preclinical Antiseizure Activity. [PDF]

ACS Med Chem Lett
Sun S, Jia Q, Bankar G, Burford KN, Christabel J, Clement HA, de Boer G, Feng Z, Hambira CM, Jackson SK, Khakh K, Kwan R, Lee S, Li J, Lindgren A, Mezeyova J, Sabbatini J, Urrutia A, Charifson P, Clark MP, Wesolowski SS, Johnson JP, Empfield JR, Dehnhardt CM, Dean R.   +24 more
europepmc   +1 more source

Impaired adrenergic regulation of Kv channels underlies LC hyperactivity and early-onset sleep disruption in AD-like amyloidogenic mice. [PDF]

Alzheimers Dement
Zhang YC, Zhang XT, Chen PY, Zhou ZY, Huang MQ, He KW.   +5 more
europepmc   +1 more source

Endosomal 2Cl-/H+ exchangers regulate neuronal excitability by tuning Kv7/KCNQ channel density. [PDF]

Brain
Qi G, Diaz-Castillo A, Aretzweiler C, Steinmetz L, Bungert-Plümke S, Müller F, Feldmeyer D, Guzman RE.   +7 more
europepmc   +1 more source

Modulation of Nociceptive Ion Channels by Protease-Activated Receptor-2 in Inflammatory Pain: Molecular Mechanisms and Therapeutic Potential. [PDF]

Int J Mol Sci
Aburamadan H, Lozon Y, Cyril AC, Parambath AN, Ali NM, Jan RK, Plevin R, Radhakrishnan R.   +7 more
europepmc   +1 more source

Efficacy of a K⁺ Channel Agonist, XEN1101, For Preserving Contractility in Mouse Models of Hypokalemic Periodic Paralysis. [PDF]

Muscle Nerve
Chanchykov V, Iype S, Quinonez M, Wu F, Cannon S.   +4 more
europepmc   +1 more source

Potassium channel-targeted therapy in reducing vascular complications in diabetes mellitus: novel insights. [PDF]

Front Pharmacol
Rajkovic J, Ribic A, Rekovic L, Gostimirovic M, Bukarica A, Terzic D, Gojkovic-Bukarica L.   +6 more
europepmc   +1 more source

Cannabidiol inhibits both human K_V7.1 and K_V7.1/KCNE1 channels through distinct sites. [PDF]

Acta Pharmacol Sin
Kusay AS, Pökl M, Hiniesto-Iñigo I, Sridhar A, Delemotte L, Liin SI.   +5 more
europepmc   +1 more source

H₂O₂-mediated relaxation in a swine model of ischemic heart disease and exercise training: mechanistic insights and the role of Kv7 channels. [PDF]

Basic Res Cardiol
Self TS, Bray JF, Heaps CL.
europepmc   +1 more source

Antiseizure Medications in Development: Novel Mechanisms, Precision Therapy, and the Move Towards Disease Modification. [PDF]

Curr Issues Mol Biol
Martins WA.
europepmc   +1 more source

Shining Light on the Neuropathology of Temporal Lobe Epilepsy. [PDF]

Epilepsy Curr
Scharfman HE.
europepmc   +1 more source