Results 91 to 100 of about 3,560 (160)

Neuropathic pain and Kv7 voltage-gated potassium channels: The potential role of Kv7 activators in the treatment of neuropathic pain

Molecular Pain, 2019
Neuropathic pain conditions severely and chronically affect the quality of life in a large human population, but the pain conditions are not adequately managed due to poor understanding of their underlying mechanisms. There is a pressing need for further
Alaa Abd-Elsayed, Markus Jackson, Steven L Gu, Kenneth Fiala, Jianguo Gu   +4 more
doaj   +1 more source

Injection or removal of Kv7 conductance by dynamic clamp reverses or mimics the effects of XE-991.

, 2013
A) Changes in membrane potential and input resistance caused by introduction of negative dynamic clamp Kv7 conductance (blue bar), XE-991 (10 µM, red bar) and positive dynamic clamp Kv7 conductance (green bar).
Milos M. Petrovic (333174), Andrew D. Randall (333180), Valeria Olivo (333178), Jakub Nowacki (333176), Krasimira Tsaneva-Atanasova (144624), Jack R. Mellor (333181)   +5 more
core   +1 more source

rdHSV-CA8 non-opioid analgesic gene therapy decreases somatosensory neuronal excitability by activating Kv7 voltage-gated potassium channels

Frontiers in Molecular Neuroscience
Chronic pain is common and inadequately treated, making the development of safe and effective analgesics a high priority. Our previous data indicate that carbonic anhydrase-8 (CA8) expression in dorsal root ganglia (DRG) mediates analgesia via inhibition
Munal B. Kandel, Gerald Z. Zhuang, William F. Goins, Marco Marzulli, Mingdi Zhang, Joseph C. Glorioso, Yuan Kang, Alexandra E. Levitt, Wai-Meng Kwok, Roy C. Levitt, Roy C. Levitt, Roy C. Levitt, Roy C. Levitt, Konstantinos D. Sarantopoulos, Konstantinos D. Sarantopoulos   +14 more
doaj   +1 more source

The role of Kv7 in peripheral neurons [PDF]

, 2012
The Kv7 (KCNQ) channel is a family of voltage-gated potassium channels that is considered to be important in the regulation of cellular excitability and axonal conduction.
King, Chih Houng, King, Chih
core  

Kv7 K+ Channels in Airway Smooth Muscle Cells as Target for Asthma Therapy [PDF]

, 2012
Airway hyperresponsiveness (AHR) is an important etiological feature of asthma, the molecular mechanisms of which are poorly understood, thus preventing development of specific and effective therapies.
Kakad, Priyanka Prakash
core   +1 more source

Participation of calcium-permeable AMPA receptors in the regulation of epileptiform activity of hippocampal neurons

Frontiers in Synaptic Neuroscience
IntroductionEpileptiform activity is the most striking result of hyperexcitation of a group of neurons that can occur in different brain regions and then spread to other sites.
Valery Petrovich Zinchenko, Ilia Yu. Teplov, Artem Mikhailovich Kosenkov, Sergei Gennadievich Gaidin, Bakytzhan Kairatuly Kairat, Sultan Tuleukhanovich Tuleukhanov   +5 more
doaj   +1 more source

KV7 channels regulate muscle tone and nonadrenergic noncholinergic relaxation of the rat gastric fundus

, 2011
Voltage-dependent type 7 K+ (KV7) channels play important physiological roles in neurons and muscle cells. The aims of the present study were to investigate the motor effects of KV7 channel modulators in the rat gastric fundus and the expression of KV7
TAGLIALATELA, MAURIZIO, Currò, D., Martire, Maria, M. Taglialatela, Ipavec, V, V. Ipavec, Curro', Diego, V. Barrese, D. Currò, Martire, M, Barrese, V, M. Martire   +11 more
core   +1 more source

Activation of KV7 channels stimulates vasodilatation of human placental chorionic plate arteries.

, 2015
Introduction: Potassium (K(+)) channels are key regulators of vascular smooth muscle cell (VSMC) excitability. In systemic small arteries, Kv7 channel expression/activity has been noted and a role in vascular tone regulation demonstrated.
Robinson, M, Cottrell, Elizabeth; id_orcid, Greenwood, Susan, Hayward, Christina, Shweikh, Y, Dalby-Brown, W, Tropea, T, Mills, Tracey, Devlin, G, Cowley, E, Brereton, Melissa, Wareing, Mark   +11 more
core   +1 more source

Disease-modifying rdHSV-CA8* non-opioid analgesic gene therapy treats chronic osteoarthritis pain by activating Kv7 voltage-gated potassium channels

Frontiers in Molecular Neuroscience
Chronic pain is common in our population, and most of these patients are inadequately treated, making the development of safer analgesics a high priority.
Gerald Z. Zhuang, William F. Goins, Munal B. Kandel, Marco Marzulli, Mingdi Zhang, Joseph C. Glorioso, Yuan Kang, Alexandra E. Levitt, Konstantinos D. Sarantopoulos, Konstantinos D. Sarantopoulos, Roy C. Levitt, Roy C. Levitt, Roy C. Levitt, Roy C. Levitt   +13 more
doaj   +1 more source

G protein βγ regulation of KCNQ-encoded voltage-dependent K channels

Frontiers in Physiology
The KCNQ family is comprised of five genes and the expression products form voltage-gated potassium channels (Kv7.1–7.5) that have a major impact upon cellular physiology in many cell types.
Jennifer B. Stott, Iain A. Greenwood
doaj   +1 more source