Genetic and pharmacological studies of KV7 channels in excitability disorders
The KV7 (KCNQ) subfamily of voltage-gated potassium channels plays a key role in the regulation of neuronal excitability. By controlling the neuronal M-current, KV7 channels represent pharmacological targets for neurological disorders characterized by ...
LUZIO GASPAR, INGRIDE
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Die Rolle neuronaler Kv7-Kanäle in der antinozizeptive Wirkung von Paracetamol
, 2018 Paracetamol, auch genannt Acetaminophen (APAP), ist eines der am häufigsten eingesetzten Schmerzmittel weltweit. Der Wirkmechanismus ist weitgehend ungeklärt, obwohl eine Reihe von möglichen Mechanismen vorgeschlagen wurde.
Ray, Sutirtha
core
Altered axonal initial segment development links circuit and Kv7 dysfunction in an Fmr1 knockout rat
Fragile X syndrome (FXS) is the leading monogenetic cause of intellectual disability and autism, yet how basic hippocampal circuit properties evolve across development for this condition remains unclear.
Michael A. Cousin +2 more
core +1 more source
The role of neuronal Kv7 channels in the antinociceptive action of paracetamol
, 2018 Paracetamol, auch genannt Acetaminophen (APAP), ist eines der am häufigsten eingesetzten Schmerzmittel weltweit. Der Wirkmechanismus ist weitgehend ungeklärt, obwohl eine Reihe von möglichen Mechanismen vorgeschlagen wurde.
Ray, Sutirtha
core
Physiological 17β-oestradiol inhibits K<sub>V</sub>7.4 currents via GPER1-dependent PLC/PKC signalling. [PDF]
Channels (Austin)Karabatak E +5 more
europepmc +1 more source
From Retigabine to Azetukalner: Reviving Voltage-Gated Potassium Channels for Epilepsy Therapy. [PDF]
Arch Pharm (Weinheim)Rosendahl P, Schulig L, Link A.
europepmc +1 more source
Ion Channels as Therapeutic Targets in Overactive Bladder: A Narrative Review of Mechanisms, Translational Evidence, and Current Gaps. [PDF]
Low Urin Tract SymptomsDemirçi B +3 more
europepmc +1 more source
Assessment of gabapentin efficacy in patients with KCNQ2-developmental epileptic encephalopathy. [PDF]
Sci RepXiong J +10 more
europepmc +1 more source
Efficacy of Retigabine in Treating Weakness in a Mouse Model of Hypokalemic Periodic Paralysis. [PDF]
Muscle NerveDenman K, Rich MM.
europepmc +1 more source
μ-Opioid receptor signalling enhances Kir3 currents in glutamatergic preBötzinger complex neurons in mice. [PDF]
J PhysiolKalajian EJ +3 more
europepmc +1 more source