Results 81 to 90 of about 3,560 (160)

Electro‐Mechanical Uncoupling of KV7.1 Voltage Sensor and Pore by 1,4‐Benzodiazepines Is Modulated by Decoration of Position 1

Archiv der Pharmazie, Volume 359, Issue 7, July 2026.
Loss‐of‐function mutations of the voltage‐gated potassium channel KV7.1 (KCNQ1) can lead to malignant arrhythmia. The effects of five 1,4‐benzodiazepines modified at the lactam on KV7.1 gating were thoroughly analysed by two‐electrode voltage clamp experiments.
Florian Roßner, Thomas Jepps, Bo Hjorth Bentzen, Nathalie Strutz‐Seebohm, Bernhard Wünsch, Guiscard Seebohm   +5 more
wiley   +1 more source

Epilepsy: Epidemiology, Molecular Pathogenesis, and Clinical Management

MedComm, Volume 7, Issue 7, July 2026.
Epilepsy is a heterogeneous and chronically evolving brain network disorder. This review integrates epidemiological burden, psychiatric comorbidities, and cyclic seizure patterns with multiscale pathogenic mechanisms, including ion‐channel dysfunction, synaptic transmission defects, neuroinflammation, metabolic and mitochondrial dysfunction, and ...
Jian Liu, Xinyan Wu, Ting Yin, Feining Huang, Manqi Kong, Yu Yang, Zinan Liu, Jiabin Yu, Tianpeng Zhang   +8 more
wiley   +1 more source

The renal vasodilatation from β‐adrenergic activation in vivo in rats is not driven by KV7 and BKCa channels

Experimental Physiology
The mechanisms behind renal vasodilatation elicited by stimulation of β‐adrenergic receptors are not clarified. As several classes of K channels are potentially activated, we tested the hypothesis that KV7 and BKCa channels contribute to the decreased ...
Charlotte Mehlin Sorensen, Max Salomonsson, Anniek Frederike Lubberding, Niels‐Henrik Holstein‐Rathlou   +3 more
doaj   +1 more source

The M-Channel Blocker Linopirdine Is an Agonist of the Capsaicin Receptor TRPV1

Journal of Pharmacological Sciences, 2010
.: Linopirdine is a well known blocker of voltage-gated potassium channels from the Kv7 (or KCNQ) family that generate the so called M current in mammalian neurons.
Cristian Neacsu, Alexandru Babes
doaj   +1 more source

Identifying KIF Subtype that Mediates Axonal Targeting of Kv7 Channels [PDF]

, 2018
Early-onset Benign Familial Neonatal Epilepsy (BFNE) and Epileptic Encephalopathy (EE), are associated with mutations in neuronal KCNQ/Kv7 channel subunits Kv7.2 and Kv7.3. Kv7 channels are voltage-dependent potassium channels.
Chung, Hee Jung, Houghton, Allison, Walters, Jennifer, Joshi, Dhruv, Hong, Mary   +4 more
core  

The Natural Plant Product Rottlerin Activates Kv7.1/KCNE1 Channels

Cellular Physiology and Biochemistry, 2016
Background/Aims: Acquired as well as inherited channelopathies are disorders that are caused by altered ion channel function. A family of channels whose malfunction is associated with different channelopathies is the Kv7 K+ channel family; and ...
Veronika Matschke, Ilaria Piccini, Janina Schubert, Eva Wrobel, Florian Lang, Johann Matschke, Elsie Amedonu, Sven G. Meuth, Timo Strünker, Nathalie Strutz-Seebohm, Boris Greber, Jürgen Scherkenbeck, Guiscard Seebohm   +12 more
doaj   +1 more source

Endocannabinoids Tune Intrinsic Excitability in O-LM Interneurons by Direct Modulation of Postsynaptic Kv7 Channels

, 2021
International audienceKCNQ-Kv7 channels are found at the axon initial segment of pyramidal neurons, where they control cell firing and membrane potential.
Azzaz, Fodil, Fantini, Jacques, Russier, Michael, Sammari, Malika, Debanne, Dominique, Incontro, Salvatore, Ankri, Norbert, Inglebert, Yanis   +7 more
core   +1 more source

KV7 Channels Regulate Firing during Synaptic Integration in GABAergic Striatal Neurons

Neural Plasticity, 2015
Striatal projection neurons (SPNs) process motor and cognitive information. Their activity is affected by Parkinson’s disease, in which dopamine concentration is decreased and acetylcholine concentration is increased.
M. Belén Pérez-Ramírez, Antonio Laville, Dagoberto Tapia, Mariana Duhne, Esther Lara-González, José Bargas, Elvira Galarraga   +6 more
doaj   +1 more source

Abstracts

Molecular Oncology, Volume 20, Issue S1, Page 1-692, August 2026.
Abstracts submitted to the ‘EACR 2026 Congress: Innovative Cancer Science’, from 08–11 June 2026 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +1 more source

One man's side effect is another man's therapeutic opportunity:targeting Kv7 channels in smooth muscle disorders

, 2013
Retigabine is a first in class anticonvulsant that has recently undergone clinical trials to test its efficacy in epileptic patients. Retigabine's novel mechanism of action - activating Kv7 channels - suppresses neuronal activity to prevent seizure ...
Olesen, S P, Greenwood, I A, Jepps, Thomas Andrew   +2 more
core   +1 more source