Results 51 to 60 of about 3,560 (160)
PLoS Biology, 2023 Neurons tightly regulate firing rate and a failure to do so leads to multiple neurological disorders. Therefore, a fundamental question in neuroscience is how neurons produce reliable activity patterns for decades to generate behavior. Neurons have built-
Sarah Pellizzari +4 more
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Targeting Kv7 Potassium Channels for Epilepsy. [PDF]
CNS DrugsVoltage-gated Kv7 potassium channels, particularly Kv7.2 and Kv.7.3 channels, play a critical role in modulating susceptibility to seizures, and mutations in genes that encode these channels cause heterogeneous epilepsy phenotypes.
Perucca E, Taglialatela M.
europepmc +2 more sources
The Role of Kv7 Channels in Neural Plasticity and Behavior
Frontiers in Physiology, 2020 Activity-dependent persistent changes in neuronal intrinsic excitability and synaptic strength are widely thought to underlie learning and memory. Voltage-gated KCNQ/Kv7 potassium channels have been of great interest as the potential targets for memory ...
Brian C. Baculis +3 more
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Nature Communications, 2023 Autism spectrum disorders (ASD) represent neurodevelopmental disorders characterized by social deficits, repetitive behaviors, and various comorbidities, including epilepsy. ANK2, which encodes a neuronal scaffolding protein, is frequently mutated in ASD,
Hyoseon Oh +20 more
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BMC Pharmacology and Toxicology, 2021 Background The objective of the present study was to determine the effect of allisartan, a new angiotensin II type 1 receptor antagonist on vascular remodeling through voltage gated potassium channels (Kv7) in hypertensive rats.
Xiaoqin Zhang +4 more
doaj +1 more source
Molecular Basis for Activation to Inhibition Switching in Kv7.2 Channel Modulators
Angewandte Chemie International Edition, EarlyView.The paper describes the serendipitous discovery of chemical manipulation allowing the activator‐to‐inhibitor switching in Kv7.2 channel modulators. The molecular determinants driving this switch have been rationalized by multidisciplinary investigation encompassing synthetic and analytical chemistry, in silico methods, cryo‐EM analysis ...
Tania Ciaglia +20 more
wiley +1 more source
The role of potassium channel activation in celecoxib-induced analgesic action. [PDF]
PLoS ONE, 2013 BACKGROUND AND PURPOSE: Celecoxib (CXB) is a widely prescribed COX-2 inhibitor used clinically to treat pain and inflammation. Recently, COX-2 independent mechanisms have been described to be the targets of CXB.
Yao Mi +8 more
doaj +1 more source
British Journal of Pharmacology, EarlyView.Obesity is a chronic, relapsing, multisystem disease in which cardiometabolic risk arises from excess adiposity and progressive dysfunction of peripheral organs, ultimately disrupting endocrine and metabolic crosstalk among tissues. Within this network, sulphur‐based biology, centred on hydrogen sulphide and related reactive sulphur species, has ...
Martina Smimmo +4 more
wiley +1 more source
, 2015 Aims Voltage-gated potassium channels encoded by KCNQ genes (Kv7 channels) are emerging as important regulators of vascular tone. In this study, we analysed the contribution of Kv7 channels to the vasodilation induced by hypoxia and the cyclic AMP ...
Jimenez, Rosario +13 more
core +1 more source
Role and Mechanism of Polyunsaturated Fatty Acids on Potassium Ion Channels
Shengwu huaxue yu shengwu wuli jinzhanPolyunsaturated fatty acids (PUFAs) have diverse health-promoting effects, such as potentially protecting in immune, nervous, and cardiovascular systems by targeting a variety of sites, including most ion channels. Voltage-gated potassium channels of the
SUN Yu-Jiao +4 more
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