Results 41 to 50 of about 3,560 (160)

Roles of perivascular adipose tissue and Kv7 voltage‐dependent potassium channels in vascular tone [PDF]

, 2023
Hypertension is widely acknowledged as a major risk factor in the progression of many vascular diseases, especially for elderlies. The vascular tone plays a key role in several major areas of research. The Kv7 voltage-dependent potassium channels (also
Wang, Yibin
core   +1 more source

Functional and molecular evidence for Kv7 channel subtypes in human detrusor from patients with and without bladder outflow obstruction.

PLoS ONE, 2015
The aim of the study was to investigate whether Kv7 channels and their ancillary β-subunits, KCNE, are functionally expressed in the human urinary bladder.
Julie Svalø, Majid Sheykhzade, Jørgen Nordling, Christina Matras, Pierre Bouchelouche   +4 more
doaj   +1 more source

Kynurenine causes vasodilation and hypotension induced by activation of KCNQ-encoded voltage-dependent K+ channels

Journal of Pharmacological Sciences, 2015
Kynurenine is a potential contributor to hypotension in animal and human sepsis. The present study was designed to examine whether the voltage-dependent K+ channels encoded by the KCNQ gene family (Kv7 channels) mediate vasodilator effects of kynurenine ...
Kensuke Sakakibara, Guo-Gang Feng, Jiazheng Li, Takahiko Akahori, Yoshitaka Yasuda, Emi Nakamura, Noboru Hatakeyama, Yoshihiro Fujiwara, Hiroyuki Kinoshita   +8 more
doaj   +1 more source

Modulation of Kv7 channels and excitability in the brain [PDF]

, 2017
Neuronal Kv7 channels underlie a voltage-gated non-inactivating potassium current known as the M-current. Due to its particular characteristics, Kv7 channels show pronounced control over the excitability of neurons.
Greene, Derek L, Hoshi, Naoto
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Kv7(KCNQ)-K+-Channels Influence Total Peripheral Resistance in Female but Not Male Rats, and Hamper Catecholamine Release in Hypertensive Rats of Both Sexes

Frontiers in Physiology, 2018
K+-channels of the Kv7/KCNQ-family hyperpolarize and stabilize excitable cells such as autonomic neurons and vascular smooth muscle cells (VSMC). Kv7 may therefore play a role in blood pressure (BP) homeostasis, and prevent a high total peripheral ...
Torill Berg
doaj   +1 more source

Structural Insight into KCNQ (Kv7) Channel Assembly and Channelopathy [PDF]

, 2007
SummaryKv7.x (KCNQ) voltage-gated potassium channels form the cardiac and auditory IKs current and the neuronal M-current. The five Kv7 subtypes have distinct assembly preferences encoded by a C-terminal cytoplasmic assembly domain, the A-domain Tail ...
Holton, James M., Clark, Kimberly A., Minor, Daniel L., Howard, Rebecca J.   +3 more
core   +1 more source

Kv7 channels can function without constitutive calmodulin tethering.

PLoS ONE, 2011
M-channels are voltage-gated potassium channels composed of Kv7.2-7.5 subunits that serve as important regulators of neuronal excitability. Calmodulin binding is required for Kv7 channel function and mutations in Kv7.2 that disrupt calmodulin binding ...
Juan Camilo Gómez-Posada, Paloma Aivar, Araitz Alberdi, Alessandro Alaimo, Ainhoa Etxeberría, Juncal Fernández-Orth, Teresa Zamalloa, Meritxell Roura-Ferrer, Patricia Villace, Pilar Areso, Oscar Casis, Alvaro Villarroel   +11 more
doaj   +1 more source

The Gβ1 and Gβ3 Subunits Differentially Regulate Rat Vascular Kv7 Channels

Frontiers in Physiology, 2020
Within the vasculature Kv7 channels are key regulators of basal tone and contribute to a variety of receptor mediated vasorelaxants. The Kv7.4 isoform, abundant within the vasculature, is key to these processes and was recently shown to have an ...
Iain A. Greenwood, Jennifer B. Stott
doaj   +1 more source

The actions of Pasteurella multocida toxin on neuronal cells [PDF]

, 2014
Pasteurella multocida toxin (PMT) activates the G-proteins Gα, Gα, Gα Gα and Gα by deamidation of specific glutamine residues. A number of these alpha subunits have signalling roles in neurones.
Lax, Alistair; id_orcid, Robbins, Jon, Duricki, DA, Surguy, SM, Duricki, Denise A., Duricki, Denise, Lax, AJ, Reilly, JM, Reilly, Joanne, Surguy, Susan, Surguy, Susan M., Reilly, Joanne M., Robbins, J, Lax, Alistair J.   +13 more
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M-Current Suppression, Seizures and Lipid Metabolism: A Potential Link Between Neuronal Kv7 Channel Regulation and Dietary Therapies for Epilepsy

Frontiers in Physiology, 2020
Neuronal Kv7 channel generates a low voltage-activated potassium current known as the M-current. The M-current can be suppressed by various neurotransmitters that activate Gq-coupled receptors.
Naoto Hoshi, Naoto Hoshi
doaj   +1 more source