Results 21 to 30 of about 3,560 (160)

From pan-reactive KV7 channel opener to subtype selective opener/inhibitor by addition of a methyl group. [PDF]

PLoS ONE, 2014
The voltage-gated potassium channels of the KV7 family (KV7.1-5) play important roles in controlling neuronal excitability and are therefore attractive targets for treatment of CNS disorders linked to hyperexcitability.
Sigrid Marie Blom, Mario Rottländer, Jan Kehler, Christoffer Bundgaard, Nicole Schmitt, Henrik Sindal Jensen   +5 more
doaj   +1 more source

Site and Mechanism of ML252 Inhibition of Kv7 Voltage-Gated Potassium Channels

Function, 2023
Kv7 (KCNQ) voltage-gated potassium channels are critical regulators of neuronal excitability and are candidate targets for development of antiseizure medications.
Richard Kanyo, Shawn M Lamothe, Arturo Urrutia, Samuel J Goodchild, W Ted Allison, Richard Dean, Harley T Kurata   +6 more
doaj   +1 more source

Molecular expression and pharmacological evidence for a functional role of kv7 channel subtypes in Guinea pig urinary bladder smooth muscle. [PDF]

PLoS ONE, 2013
Voltage-gated Kv7 (KCNQ) channels are emerging as essential regulators of smooth muscle excitability and contractility. However, their physiological role in detrusor smooth muscle (DSM) remains to be elucidated. Here, we explored the molecular expression
Serge A Y Afeli, John Malysz, Georgi V Petkov   +2 more
doaj   +1 more source

The Functional Availability of Arterial Kv7 Channels Is Suppressed Considerably by Large-Conductance Calcium-Activated Potassium Channels in 2- to 3-Month Old but Not in 10- to 15-Day Old Rats

Frontiers in Physiology, 2020
BackgroundVoltage-gated potassium (Kv) channels, especially Kv7 channels, are major potassium channels identified in vascular smooth muscle cells with a great, albeit differential functional impact in various vessels.
Dongyu Ma, Dongyu Ma, Dina Gaynullina, Dina Gaynullina, Nadine Schmidt, Mitko Mladenov, Mitko Mladenov, Rudolf Schubert, Rudolf Schubert   +8 more
doaj   +1 more source

Kv7 Channels as an Important Contributor to Alcohol-Induced Modulation of Neuronal Excitability in Neonatal Rat Superior Cervical Ganglion. [PDF]

Cells
Normal alcohols (n-alcohols) exhibit contrasting effects on neuronal excitability; specifically, ethanol enhances neuronal firing, while hexanol suppresses it. Both compounds are known to inhibit sodium currents, yet the mechanisms behind their differing
Jeong DJ, Woo JN, Yun T, Baek M, Suh BC.
europepmc   +2 more sources

Ganoderic Acid A Ameliorates Pentylenetetrazol-Induced Epilepsy in Mice via Activating KCNQ2. [PDF]

CNS Neurosci Ther
GA‐A binds and activates KCNQ2, thereby reducing epileptic‐like EEG discharges, the loss and apoptosis of hippocampal neurons, and improving anxiety and depression‐like behavioral changes. In addition, GA‐A inhibits neuroinflammation and alleviates oxidative stress independent of activating KCNQ2.
Yao Y, Liu Z, Wang X, Bian C, Wang R, Zhang Y.   +5 more
europepmc   +2 more sources

Kv7 and Kv11 channels in myometrial regulation. [PDF]

, 2013
Ion channels play a key role in defining myometrial contractility. Modulation of ion channel populations is proposed to underpin gestational changes in uterine contractility associated with the transition from uterine quiescence to active labour.
Tribe, Rachel M; id_orcid, Greenwood, IA, Rachel M. Tribe, Greenwood, Iain, Iain A. Greenwood, Tribe, RM   +5 more
core   +1 more source

Nicotine enhances object recognition memory through inhibition of voltage-dependent potassium 7 channels in the medial prefrontal cortex of mice

Journal of Pharmacological Sciences, 2021
Nicotine administration enhances object recognition memory. However, target brain regions and cellular mechanisms underlying the nicotine effects remain unclear.
Hirohito Esaki, Shoma Izumi, Akari Fukao, Naoya Nishitani, Satoshi Deyama, Katsuyuki Kaneda   +5 more
doaj   +1 more source

The contribution of Kv7 channels to pregnant mouse and human myometrial contractility. [PDF]

, 2011
Premature birth accounts for approximately 75% of neonatal mortality and morbidity in the developed world. Despite this, methods for identifying and treating women at risk of preterm labour are limited and many women still present in preterm labour ...
Pierce, SL, Greenwood, Iain A., Greenwood, IA, Tribe, Rachel M.; id_orcid, McCallum, LA, England, SK, McCallum, Laura A., Tribe, RM, England, Sarah K., Pierce, Stephanie L.   +9 more
core   +1 more source

Inhibition of M/Kv7 Currents Contributes to Chloroquine-Induced Itch in Mice

Frontiers in Molecular Neuroscience, 2020
M/Kv7 potassium channels play a key role in regulation of neuronal excitability. Modulation of neuronal excitability of primary sensory neurons determines the itch sensation induced by a variety of itch-causing substances including chloroquine (CQ).
Dong Zhang, Dong Zhang, Dong Zhang, Dong Zhang, Dong Zhang, Hongchao Men, Hongchao Men, Hongchao Men, Hongchao Men, Hongchao Men, Ludi Zhang, Ludi Zhang, Ludi Zhang, Ludi Zhang, Xiangxin Gao, Xiangxin Gao, Xiangxin Gao, Xiangxin Gao, Jingjing Wang, Jingjing Wang, Jingjing Wang, Jingjing Wang, Leying Li, Leying Li, Leying Li, Leying Li, Qiaoying Zhu, Qiaoying Zhu, Qiaoying Zhu, Qiaoying Zhu, Hailin Zhang, Hailin Zhang, Hailin Zhang, Hailin Zhang, Zhanfeng Jia, Zhanfeng Jia, Zhanfeng Jia, Zhanfeng Jia   +37 more
doaj   +1 more source