Inhibition of post-synaptic Kv7/KCNQ/M channels facilitates long-term potentiation in the hippocampus. [PDF]
PLoS ONE, 2012 Activation of muscarinic acetylcholine receptors (mAChR) facilitates the induction of synaptic plasticity and enhances cognitive function. In the hippocampus, M(1) mAChR on CA1 pyramidal cells inhibit both small conductance Ca(2+)-activated KCa2 ...
Milos M Petrovic +5 more
doaj +11 more sources
Cyclic AMP-Dependent Regulation of Kv7 Voltage-Gated Potassium Channels [PDF]
Frontiers in Physiology, 2020 Voltage-gated Kv7 potassium channels, encoded by KCNQ genes, have major physiological impacts cardiac myocytes, neurons, epithelial cells, and smooth muscle cells. Cyclic adenosine monophosphate (cAMP), a well-known intracellular secondary messenger, can
Jennifer van der Horst +2 more
doaj +2 more sources
The Kv7 Channel and Cardiovascular Risk Factors
Frontiers in Cardiovascular Medicine, 2017 Potassium channels play a pivotal role in the regulation of excitability in cells such as neurons, cardiac myocytes, and vascular smooth muscle cells.
Andreas L. Fosmo, Øyvind B. Skraastad
doaj +2 more sources
KV7 Channel Expression and Function Within Rat Mesenteric Endothelial Cells [PDF]
Frontiers in Physiology, 2020 Background and Purpose: Arterial diameter is dictated by the contractile state of the vascular smooth muscle cells (VSMCs), which is modulated by direct and indirect inputs from endothelial cells (ECs).
Samuel N. Baldwin +4 more
doaj +2 more sources
Uncovered Contribution of Kv7 Channels to Pulmonary Vascular Tone in Pulmonary Arterial Hypertension [PDF]
, 2020 K+ channels play a fundamental role regulating membrane potential of pulmonary artery (PA) smooth muscle cells and their impairment is a common feature in pulmonary arterial hypertension (PAH).
Greenwood, Iain A. +11 more
core +3 more sources
Frontiers in Physiology, 2020 Lung diseases constitute a global health concern causing disability. According to WHO in 2016, respiratory diseases accounted for 24% of world population mortality, the second cause of death after cardiovascular diseases.
Gema Mondejar-Parreño +8 more
doaj +1 more source
Novel Roles for Kv7 Channels in Shaping Histamine-Induced Contractions and Bradykinin-Dependent Relaxations in Pig Coronary Arteries. [PDF]
PLoS ONE, 2016 Voltage-gated Kv7 channels are inhibited by agonists of Gq-protein-coupled receptors, such as histamine. Recent works have provided evidence that inhibition of vascular Kv7 channels may trigger vessel contractions.
Xingjuan Chen +3 more
doaj +1 more source
The novel KV7 channel activator URO-K10 exerts enhanced pulmonary vascular effects independent of the KCNE4 regulatory subunit [PDF]
, 2023 KV7 channels exert a pivotal role regulating vascular tone in several vascular beds. In this context, KV7 channel agonists represent an attractive strategy for the treatment of pulmonary arterial hypertension (PAH).
Göcken Telli +55 more
core +1 more source
Polyunsaturated Fatty Acids as Modulators of KV7 Channels
Frontiers in Physiology, 2020 Voltage-gated potassium channels of the KV7 family are expressed in many tissues. The physiological importance of KV7 channels is evident from specific forms of disorders linked to dysfunctional KV7 channels, including variants of epilepsy, cardiac ...
Johan E. Larsson +2 more
doaj +1 more source
Dehydroepiandrosterone sulfate (DHEAS) is an endogenous Kv7 channel modulator that reduces Kv7/M-current suppression and inflammatory pains [PDF]
, 2023 Neuronal Kv7 voltage-gated potassium channels generate the M-current and regulate neuronal excitability. Here, we report that dehydroepiandrosterone sulfate (DHEAS) is an endogenous Kv7 channel modulator that attenuates Gq-coupled receptor-induced M ...
Alhassen, Lamees +13 more
core +1 more source