Kv7 Channels and Excitability Disorders
, 2021 Kv7.1-Kv7.5 (KCNQ1–5) K+ channels are voltage-gated K+ channels with major roles in neurons, muscle cells and epithelia where they underlie physiologically important K+ currents, such as neuronal M current and cardiac IKs. Specific biophysical properties
Haixia Gao +5 more
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The Journal of Clinical Investigation, 2023 Multiple sclerosis (MS) is a progressive inflammatory demyelinating disease of the CNS. Increasing evidence suggests that vulnerable neurons in MS exhibit fatal metabolic exhaustion over time, a phenomenon hypothesized to be caused by chronic ...
Hannah Kapell +41 more
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Vitamin D Receptor Deficiency Upregulates Pulmonary Artery Kv7 Channel Activity
, 2023 Horizonte 2020. Marie-Curie Nº 847635.Recent evidence suggests that vitamin D is involved in the development of pulmonary arterial hypertension (PAH). The aim of this study was to analyze the electrophysiological and contractile properties of pulmonary ...
Sancho González, María +8 more
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Sexual dimorphisms in vascular KV7 channels [PDF]
Introduction: Kcnq-encoded KV7 channels (termed KV7.1-5) are essential regulators of vascular physiology and are associated with pathophysiological states, however, vascular studies on Kv7 channels to date have focussed almost solely on arteries from ...
Baldwin, S. N.
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The expression and function of KCNQ potassium channels in human chorionic plate arteries from women with normal pregnancies and pre-eclampsia. [PDF]
PLoS ONE, 2018 Pre-eclampsia is associated with altered maternal and placental vascular reactivity. Kv7 channels (encoded by KCNQ 1-5 genes) are a potential contributor to the regulation of vascular tone in CPAs (chorionic plate arteries) during normal pregnancy.
Xiaohong Wei +5 more
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Detrusor Smooth Muscle KV7 Channels: Emerging New Regulators of Urinary Bladder Function
Frontiers in Physiology, 2020 Relaxation and contraction of the urinary bladder smooth muscle, also known as the detrusor smooth muscle (DSM), facilitate the micturition cycle. DSM contractility depends on cell excitability, which is established by the synchronized activity of ...
John Malysz +3 more
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Vascular Kv7 channels control intracellular Ca2+ dynamics in smooth muscle [PDF]
, 2020 Voltage-gated Kv7 (or KCNQ) channels control activity of excitable cells, including vascular smooth muscle cells (VSMCs), by setting their resting membrane potential and controlling other excitability parameters. Excitation-contraction coupling in muscle
Mullen, P +13 more
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Zinc pyrithione activates K+ channels and hyperpolarizes the membrane of rat pulmonary artery smooth muscle cells. [PDF]
PLoS ONE, 2018 The membrane potential helps determine pulmonary artery smooth muscle cell (PASMC) contraction. The Kv7 channel activators, retigabine and flupirtine, are thought to dilate pulmonary arteries by hyperpolarising PASMC.
Basma G Eid, Alison M Gurney
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Cycling matters: Sex hormone regulation of vascular potassium channels
Channels, 2023 Sex hormones and the reproductive cycle (estrus in rodents and menstrual in humans) have a known impact on arterial function. In spite of this, sex hormones and the estrus/menstrual cycle are often neglected experimental factors in vascular basic ...
Samuel N Baldwin +2 more
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Kv7 Channels in Cyclic-Nucleotide Dependent Relaxation of Rat Intra-Pulmonary Artery
Biomolecules, 2022 Pulmonary hypertension is treated with drugs that stimulate cGMP or cAMP signalling. Both nucleotides can activate Kv7 channels, leading to smooth muscle hyperpolarisation, reduced Ca2+ influx and relaxation.
Mohammed Al-Chawishly +2 more
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