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Kynurenic acid synthesis by human glioma
Journal of the Neurological Sciences, 1990Biopsy material from human gliomas obtained during neurosurgery was used to investigate whether pathological human brain tissue is capable of producing kynurenic acid (KYNA), a natural brain metabolite which can act as an antagonist at excitatory amino acid receptors.
Vezzani, A +5 more
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Production of Quinolinic Acid and Kynurenic Acid by Human Glioma
1991Using biochemical and immunohistochemical techniques, the biosynthesis of the excitotoxin quinolinic acid (QUIN) and the anti-excitotoxin kynurenic acid (KYNA) in the rat brain has been demonstrated to take place preferentially in glial cells (see Schwarcz and Du, this volume, for review). Although a dysfunction of either of these two brain metabolites
Vezzani, A +3 more
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Antagonism of kynurenic acid to anxiogens in mice
Life Sciences, 1998In a dark-light chamber in mice, kynurenic acid (KYNA, 200 mg/kg, i.p.), an endogenous neuroactive metabolite of tryptophan, attenuated the most stable effect of anxiogens in this model of anxiety--a decrease in the rate of leanings-out of the dark compartment --induced by caffeine, pentylenetetrazole and yohimbine, but not by beta-phenylethylamine ...
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Distribution, Synthesis, and Absorption of Kynurenic Acid in Plants
Planta Medica, 2010Kynurenic acid (KYNA) is an endogenous antagonist of the ionotropic glutamate receptors and the α7 nicotinic acetylcholine receptor as well as an agonist of the G-protein-coupled receptor GPR35. In this study, KYNA distribution and synthesis in plants as well as its absorption was researched.
Michał P. Turski +5 more
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EXCRETION OF KYNURENIC ACID AND XANTHURENIC ACID DURING INFECTION
Pediatrics, 1971Urinary excretion of diazotizable amines in acute febrile disease was demonstrated 90 years ago. These substances were subsequently identified as metabolites of tryptophan via the kynurenine pathway and the hepatic enzyme tryptophan pyrrolase (TP) was established as a regulator of this pathway.
R C, Shaw, R D, Feigin
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Neuropharmacology of quinolinic and kynurenic acids.
Pharmacological Reviews, 1993In a little more than 10 years, the kynurenine metabolites of tryptophan have emerged from their former position as biochemical curiosities, to occupy a prominent position in research on the causes and treatment of several major CNS disorders. The pathway includes two compounds, quinolinic acid and kynurenic acid, which are remarkably specific in their
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[Analgesic effect of kynurenic acid].
Ideggyogyaszati szemle, 2003It is well known that glutamate receptors have significant role in the pain transmission. The activation of N-methyl-D-aspartate receptors causes persistent pain, therefore the antagonists acting on these receptors cause antinociception in chronic pain states.
Gabriella, Kékesi, Gyöngyi, Horváth
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ON THE EXCRETION OF KYNURENIC ACID
American Journal of Physiology-Legacy Content, 1898Lafayette B. Mendel, Holmes C. Jackson
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Endogenous kynurenic acid and neurotoxity
2014Derkacz, Marek, Owe-Larsson, Bjorn
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Effective Activation by Kynurenic Acid and Its Aminoalkylated Derivatives on M-Type K+ Current
International Journal of Molecular Sciences, 2021Balint Lorinczi, Chih-Lung Lin
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