Results 181 to 190 of about 19,359 (226)

Comparative study on the effects of kynurenic acid and glucosamine–kynurenic acid

Pharmacology Biochemistry and Behavior, 2004
Kynurenic acid (KYNA) is the only known endogenous N-methyl-D-aspartate (NMDA) receptor inhibitor and might therefore come into consideration as a therapeutic agent in certain neurobiological disorders. However, its use as a neuroprotective compound is practically excluded because KYNA does not readily cross the blood-brain barrier (BBB).
Füvesi, Judit, Somlai, Csaba, Németh, Hajnalka, Varga, Hedvig, Kis, Zsolt, Farkas, Tamás, Károly, Norbert, Dobszay, Márton, Penke, Zsuzsa, Penke, Botond, Vécsei, László, Toldi, József   +11 more
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The kynurenic acid hypothesis of schizophrenia

Physiology & Behavior, 2007
In recent years progress in the field of schizophrenia research has led to the suggestion that dopamine only plays an intermediary role in the pathophysiology of the disease and that the main abnormalities lie elsewhere. In particular, deficits in brain glutamatergic systems are suggested to play a prominent role in the pathophysiology of the disease ...
Sophie, Erhardt, Lilly, Schwieler, Linda, Nilsson, Klas, Linderholm, Göran, Engberg   +4 more
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Endogenous kynurenic acid disrupts prepulse inhibition

Biological Psychiatry, 2004
Recent studies show that endogenous levels of kynurenic acid (KYNA) are increased in the cerebrospinal fluid of schizophrenic patients. Prepulse inhibition (PPI) of the acoustic startle reflex is an operational measure of sensorimotor gating that is reduced in neuropsychiatric disorders, such as schizophrenia.
Sophie, Erhardt, Lilly, Schwieler, Carolina, Emanuelsson, Mark, Geyer   +3 more
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Kynurenic Acid And Schizophrenia

2003
In recent years the "dopamine (DA) hypothesis of schizophrenia", has been modified into a more diversified view where an attenuated glutamatergic neurotransmission is believed to participate in the pathogenesis of the disease. Thus, schizophrenia may be regarded as a glutamate deficiency disorder.
Sophie, Erhardt, Lilly, Schwieler, Göran, Engberg   +2 more
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Kynurenic acid synthesis by human glioma

Journal of the Neurological Sciences, 1990
Biopsy material from human gliomas obtained during neurosurgery was used to investigate whether pathological human brain tissue is capable of producing kynurenic acid (KYNA), a natural brain metabolite which can act as an antagonist at excitatory amino acid receptors.
Vezzani, A, Gramsbergen, J B, Versari, P, Stasi, M A, Procaccio, F, Schwarcz, R   +5 more
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A novel kynurenic acid analogue: a comparison with kynurenic acid. An in vitro electrophysiological study

Journal of Neural Transmission, 2009
Kynurenic acid is an endogenous product of the tryptophan metabolism, and as a broad-spectrum antagonist of excitatory amino acid receptors may serve as a protective agent in neurological disorders. The use of kynurenic acid as a neuroprotective agent is rather limited, however, because it has only restricted ability to cross the blood-brain barrier ...
Marosi Máté Gábor, Nagy Dávid, Farkas Tamás, Kis Zsolt, Rózsa Éva, Robotka Hermina, Fülöp Ferenc, Vécsei László, Toldi József   +8 more
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KYNURENIC ACID — II. PHOTOSENSITIZING PROPERTIES

Photochemistry and Photobiology, 1979
Abstract— The photosensitizing properties of kynurenic acid have been studied by 353 nm laser flash spectroscopy and steady state irradiations. Laser flash spectroscopy indicates that the kynurenic acid triplet is reduced by amino acids and nucleic acid bases. Photoreactions implying singlet oxygen formation are shown to occur.
M. P. Pileni, M. Giraud, R. Santus
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Neuroprotective potency of kynurenic acid against excitotoxicity

NeuroReport, 2000
The aim of this study was to determine in vivo which extracellular levels of kynurenic acid (KYNA) are required to control excessive NMDA receptor activation in the rat cortex. As excitotoxicity is coupled to marked ion movements, local depolarisations induced by perfusion of NMDA or quinolinic acid (QUIN) through microdialysis probes were recorded at ...
J, Urenjak, T P, Obrenovitch
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KYNURENIC ACID — I. SPECTROSCOPIC PROPERTIES

Photochemistry and Photobiology, 1979
Abstract— The presence of different ground state species in ionic and/or keto s enol equilibrium has been demonstrated by studying NMR, IR and UV spectroscopic properties of kynurenic acid and related quinoline derivatives. The optical and emission properties of kynurenic acid and related compounds are thus very sensitive to pH conditions. Fluorescence
M. P. Pileni, M. Giraud, R. Santus
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Developmental changes in brain kynurenic acid concentrations

Developmental Brain Research, 1992
The cerebral distribution and regulation of excitatory amino acid levels may play a crucial role in neuronal development. In the present study we examined concentrations of the endogenous excitatory amino acid antagonist kynurenic acid and related substances during development in fetal and neonatal rat brain and fetal non-human primate cerebral cortex.
M F, Beal, K J, Swartz, O, Isacson
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