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Kynurenic acid actions in brain and periphery
International Congress Series, 2007Abstract. Kynurenic acid (KYNA) is commonly considered a non-competitive NMDA receptor antagonist. It has been recently shown that KYNA also antagonizes the alpha 7 nicotine receptors and reduces glutamate and dopamine release in the rat striatum. Finally, it has been demonstrated that KYNA interacts with GPR35, an orphan receptor negatively coupled ...
MORONI, FLAVIO +3 more
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On the toxicity of kynurenic acid in vivo and in vitro
Pharmacological Reports, 2014Kynurenic acid (KYNA), a tryptophan metabolite is an antagonist of ionotropic glutamate receptors and alpha-7 nicotinic receptor. Moreover, it is an agonist of G-protein receptor GPR35. Its neuroprotective, anticonvulsant, anti-inflammatory and antioxidant activity was documented. KYNA is present in food and herbal medicines.
Waldemar A. Turski +6 more
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Quinolinic Acid and Kynurenic Acid in the Mammalian Brain
1991Over the last decade, the study of neuroexcitatory amino acids has become one of the most rapidly expanding areas of neuroscientific research. Interest in this class of compounds was precipitated mainly by the realization that metabolites such as glutamate and aspartate are major neurotransmitters in the central nervous system (Fonnum, 1984; Erecinska ...
R, Schwarcz, F, Du
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Production of Quinolinic Acid and Kynurenic Acid by Human Glioma
1991Using biochemical and immunohistochemical techniques, the biosynthesis of the excitotoxin quinolinic acid (QUIN) and the anti-excitotoxin kynurenic acid (KYNA) in the rat brain has been demonstrated to take place preferentially in glial cells (see Schwarcz and Du, this volume, for review). Although a dysfunction of either of these two brain metabolites
Vezzani, A +3 more
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Antagonism of kynurenic acid to anxiogens in mice
Life Sciences, 1998In a dark-light chamber in mice, kynurenic acid (KYNA, 200 mg/kg, i.p.), an endogenous neuroactive metabolite of tryptophan, attenuated the most stable effect of anxiogens in this model of anxiety--a decrease in the rate of leanings-out of the dark compartment --induced by caffeine, pentylenetetrazole and yohimbine, but not by beta-phenylethylamine ...
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EXCRETION OF KYNURENIC ACID AND XANTHURENIC ACID DURING INFECTION
Pediatrics, 1971Urinary excretion of diazotizable amines in acute febrile disease was demonstrated 90 years ago. These substances were subsequently identified as metabolites of tryptophan via the kynurenine pathway and the hepatic enzyme tryptophan pyrrolase (TP) was established as a regulator of this pathway.
R C, Shaw, R D, Feigin
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Distribution, Synthesis, and Absorption of Kynurenic Acid in Plants
Planta Medica, 2010Kynurenic acid (KYNA) is an endogenous antagonist of the ionotropic glutamate receptors and the α7 nicotinic acetylcholine receptor as well as an agonist of the G-protein-coupled receptor GPR35. In this study, KYNA distribution and synthesis in plants as well as its absorption was researched.
Michal P, Turski +5 more
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Neuropharmacology of quinolinic and kynurenic acids.
Pharmacological Reviews, 1993In a little more than 10 years, the kynurenine metabolites of tryptophan have emerged from their former position as biochemical curiosities, to occupy a prominent position in research on the causes and treatment of several major CNS disorders. The pathway includes two compounds, quinolinic acid and kynurenic acid, which are remarkably specific in their
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ON THE EXCRETION OF KYNURENIC ACID
American Journal of Physiology-Legacy Content, 1898Lafayette B. Mendel, Holmes C. Jackson
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[Analgesic effect of kynurenic acid].
Ideggyogyaszati szemle, 2003It is well known that glutamate receptors have significant role in the pain transmission. The activation of N-methyl-D-aspartate receptors causes persistent pain, therefore the antagonists acting on these receptors cause antinociception in chronic pain states.
Gabriella, Kékesi, Gyöngyi, Horváth
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