Results 191 to 200 of about 19,359 (226)

Kynurenic acid actions in brain and periphery

International Congress Series, 2007
Abstract. Kynurenic acid (KYNA) is commonly considered a non-competitive NMDA receptor antagonist. It has been recently shown that KYNA also antagonizes the alpha 7 nicotine receptors and reduces glutamate and dopamine release in the rat striatum. Finally, it has been demonstrated that KYNA interacts with GPR35, an orphan receptor negatively coupled ...
MORONI, FLAVIO, S. Fossati, CHIARUGI, ALBERTO, COZZI, ANDREA   +3 more
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EXCRETION OF KYNURENIC ACID AND XANTHURENIC ACID DURING INFECTION

Pediatrics, 1971
Urinary excretion of diazotizable amines in acute febrile disease was demonstrated 90 years ago. These substances were subsequently identified as metabolites of tryptophan via the kynurenine pathway and the hepatic enzyme tryptophan pyrrolase (TP) was established as a regulator of this pathway.
R C, Shaw, R D, Feigin
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Synthesis of New Substituted Kynurenic Acids

Organic Preparations and Procedures International, 2017
Kynurenic acid (4-hydroxyquinoline-2-carboxylic acid) and its derivatives play a crucial role in maintaining normal brain function.1 Several kynurenic acid derivatives containing halo, amino, hydro...
Ajoy K. Banerjee, William J. Vera
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Tautomeric polymorphism of the neuroactive inhibitor kynurenic acid

Acta Crystallographica Section C Structural Chemistry, 2019
Kynurenic acid (KYN; systematic name: 4-hydroxyquinoline-2-carboxylic acid, C10H7NO3) displays a therapeutic effect in the treatment of some neurological diseases and is used as a broad-spectrum neuroprotective agent. However, it is understudied with respect to its solid-state chemistry and only one crystal form (α-KYN·H2O) has been reported up to now.
Dorota, Pogoda, Jan, Janczak, Sylwia, Pawlak, Michael, Zaworotko, Veneta, Videnova-Adrabinska   +4 more
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Quinolinic Acid and Kynurenic Acid in the Mammalian Brain

1991
Over the last decade, the study of neuroexcitatory amino acids has become one of the most rapidly expanding areas of neuroscientific research. Interest in this class of compounds was precipitated mainly by the realization that metabolites such as glutamate and aspartate are major neurotransmitters in the central nervous system (Fonnum, 1984; Erecinska ...
R, Schwarcz, F, Du
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Production of Quinolinic Acid and Kynurenic Acid by Human Glioma

1991
Using biochemical and immunohistochemical techniques, the biosynthesis of the excitotoxin quinolinic acid (QUIN) and the anti-excitotoxin kynurenic acid (KYNA) in the rat brain has been demonstrated to take place preferentially in glial cells (see Schwarcz and Du, this volume, for review). Although a dysfunction of either of these two brain metabolites
Vezzani, A, Gramsbergen, J B, Speciale, C, Schwarcz, R   +3 more
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[Analgesic effect of kynurenic acid].

Ideggyogyaszati szemle, 2003
It is well known that glutamate receptors have significant role in the pain transmission. The activation of N-methyl-D-aspartate receptors causes persistent pain, therefore the antagonists acting on these receptors cause antinociception in chronic pain states.
Gabriella, Kékesi, Gyöngyi, Horváth
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Neuropharmacology of quinolinic and kynurenic acids.

Pharmacological Reviews, 1993
In a little more than 10 years, the kynurenine metabolites of tryptophan have emerged from their former position as biochemical curiosities, to occupy a prominent position in research on the causes and treatment of several major CNS disorders. The pathway includes two compounds, quinolinic acid and kynurenic acid, which are remarkably specific in their
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Some central effects of kynurenic acid, 7-chlorokynurenic acid and 5,7- dichloro-kynurenic acid, glycine site antagonists.

Polish journal of pharmacology, 1995
Strychnine-insensitive glycine site is one of a few binding sites of NMDA receptor complex. The aim of these study was to find out whether compounds regarded as glycine antagonists-kynurenic acid (KA), 7-chlorokynurenic acid (7-CKA), 5,7-dichlorokynurenic acid (5,7-DCKA) evoke the effects analogous to those of the NMDA receptor antagonist, CGP 37849 ...
J, Maj, Z, Rogóz, G, Skuza, K, Kołodziejczyk   +3 more
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Kynurenic acid in ALS patients

Acta Neurologica Scandinavica, 2004
Y. Iwasaki, O. Igarashi, Y. Ichikawa, J. Aoyagi, Y. Kawase, T. Kiyozuka, H. Iguchi, K. Kawabe, M. Maruyama, K. Ikeda, T. Fujioka   +10 more
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