Results 221 to 230 of about 19,477 (272)
Fetal Sex as Moderating Factor for the Relationship Between Maternal Childhood Trauma and Salivary Kynurenic Acid and Tryptophan in Pregnancy: A Pilot Study. [PDF]
Int J Tryptophan ResPedraz-Petrozzi B +10 more
europepmc +1 more source
Hepatic kynurenic acid mediates phosphorylation of Nogo-A in the medial prefrontal cortex to regulate chronic stress-induced anxiety-like behaviors in mice. [PDF]
Acta Pharmacol SinYan L +8 more
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Comparative study on the effects of kynurenic acid and glucosamine–kynurenic acid [PDF]
Pharmacology Biochemistry and Behavior, 2004 Kynurenic acid (KYNA) is the only known endogenous N-methyl-D-aspartate (NMDA) receptor inhibitor and might therefore come into consideration as a therapeutic agent in certain neurobiological disorders. However, its use as a neuroprotective compound is practically excluded because KYNA does not readily cross the blood-brain barrier (BBB).
Tamás Farkas +13 more
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Journal of Neural Transmission, 2008
Kynurenic acid is an endogenous product of the tryptophan metabolism. Studies on the mechanism of its action have revealed that kynurenic acid at high concentrations is a competitive antagonist of the N-methyl-D-aspartate receptor and acts as a neuroprotectant in different neurological disorders.
Rózsa Éva +3 more
openaire +4 more sources
Kynurenic acid is an endogenous product of the tryptophan metabolism. Studies on the mechanism of its action have revealed that kynurenic acid at high concentrations is a competitive antagonist of the N-methyl-D-aspartate receptor and acts as a neuroprotectant in different neurological disorders.
Rózsa Éva +3 more
openaire +4 more sources
The kynurenic acid hypothesis of schizophrenia
Physiology & Behavior, 2007In recent years progress in the field of schizophrenia research has led to the suggestion that dopamine only plays an intermediary role in the pathophysiology of the disease and that the main abnormalities lie elsewhere. In particular, deficits in brain glutamatergic systems are suggested to play a prominent role in the pathophysiology of the disease ...
Sophie Erhardt +4 more
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Acta Crystallographica Section C Crystal Structure Communications, 1996
In the structure of the title compound, 4-hydroxy-2- quinolinecarboxylic acid monohydrate, C 10 H 7 NO 3 .H 2 O, the carboxyl group is ionized and the ring N atom is protonated giving it a positive charge. The molecule is almost planar. The crystal structure is stabilized both by intermolecular O-H...O and N-H...O hydrogen bonds involving the solvated ...
N. Okabe, J. Miura, A. Shimosaki
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In the structure of the title compound, 4-hydroxy-2- quinolinecarboxylic acid monohydrate, C 10 H 7 NO 3 .H 2 O, the carboxyl group is ionized and the ring N atom is protonated giving it a positive charge. The molecule is almost planar. The crystal structure is stabilized both by intermolecular O-H...O and N-H...O hydrogen bonds involving the solvated ...
N. Okabe, J. Miura, A. Shimosaki
openaire +2 more sources
Kynurenic Acid And Schizophrenia
2003In recent years the "dopamine (DA) hypothesis of schizophrenia", has been modified into a more diversified view where an attenuated glutamatergic neurotransmission is believed to participate in the pathogenesis of the disease. Thus, schizophrenia may be regarded as a glutamate deficiency disorder.
Sophie Erhardt +2 more
openaire +3 more sources
Journal of Neural Transmission, 2009
Kynurenic acid is an endogenous product of the tryptophan metabolism, and as a broad-spectrum antagonist of excitatory amino acid receptors may serve as a protective agent in neurological disorders. The use of kynurenic acid as a neuroprotective agent is rather limited, however, because it has only restricted ability to cross the blood-brain barrier ...
Marosi Máté Gábor +8 more
openaire +4 more sources
Kynurenic acid is an endogenous product of the tryptophan metabolism, and as a broad-spectrum antagonist of excitatory amino acid receptors may serve as a protective agent in neurological disorders. The use of kynurenic acid as a neuroprotective agent is rather limited, however, because it has only restricted ability to cross the blood-brain barrier ...
Marosi Máté Gábor +8 more
openaire +4 more sources