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Studies on the metabolism of kynurenic acid Enzymic formation of 7,8-ｄihydroxykynurenic acid from kynurenic acidopenaire
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Acta Crystallographica Section C Crystal Structure Communications, 1996
In the structure of the title compound, 4-hydroxy-2- quinolinecarboxylic acid monohydrate, C 10 H 7 NO 3 .H 2 O, the carboxyl group is ionized and the ring N atom is protonated giving it a positive charge. The molecule is almost planar. The crystal structure is stabilized both by intermolecular O-H...O and N-H...O hydrogen bonds involving the solvated ...
N. Okabe, J. Miura, A. Shimosaki
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In the structure of the title compound, 4-hydroxy-2- quinolinecarboxylic acid monohydrate, C 10 H 7 NO 3 .H 2 O, the carboxyl group is ionized and the ring N atom is protonated giving it a positive charge. The molecule is almost planar. The crystal structure is stabilized both by intermolecular O-H...O and N-H...O hydrogen bonds involving the solvated ...
N. Okabe, J. Miura, A. Shimosaki
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Journal of Neural Transmission, 2008
Kynurenic acid is an endogenous product of the tryptophan metabolism. Studies on the mechanism of its action have revealed that kynurenic acid at high concentrations is a competitive antagonist of the N-methyl-D-aspartate receptor and acts as a neuroprotectant in different neurological disorders.
Rózsa Éva +3 more
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Kynurenic acid is an endogenous product of the tryptophan metabolism. Studies on the mechanism of its action have revealed that kynurenic acid at high concentrations is a competitive antagonist of the N-methyl-D-aspartate receptor and acts as a neuroprotectant in different neurological disorders.
Rózsa Éva +3 more
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Comparative study on the effects of kynurenic acid and glucosamine–kynurenic acid
Pharmacology Biochemistry and Behavior, 2004Kynurenic acid (KYNA) is the only known endogenous N-methyl-D-aspartate (NMDA) receptor inhibitor and might therefore come into consideration as a therapeutic agent in certain neurobiological disorders. However, its use as a neuroprotective compound is practically excluded because KYNA does not readily cross the blood-brain barrier (BBB).
Füvesi, Judit +11 more
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The kynurenic acid hypothesis of schizophrenia
Physiology & Behavior, 2007In recent years progress in the field of schizophrenia research has led to the suggestion that dopamine only plays an intermediary role in the pathophysiology of the disease and that the main abnormalities lie elsewhere. In particular, deficits in brain glutamatergic systems are suggested to play a prominent role in the pathophysiology of the disease ...
Sophie, Erhardt +4 more
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Endogenous kynurenic acid disrupts prepulse inhibition
Biological Psychiatry, 2004Recent studies show that endogenous levels of kynurenic acid (KYNA) are increased in the cerebrospinal fluid of schizophrenic patients. Prepulse inhibition (PPI) of the acoustic startle reflex is an operational measure of sensorimotor gating that is reduced in neuropsychiatric disorders, such as schizophrenia.
Sophie, Erhardt +3 more
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Kynurenic Acid And Schizophrenia
2003In recent years the "dopamine (DA) hypothesis of schizophrenia", has been modified into a more diversified view where an attenuated glutamatergic neurotransmission is believed to participate in the pathogenesis of the disease. Thus, schizophrenia may be regarded as a glutamate deficiency disorder.
Sophie, Erhardt +2 more
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Kynurenic acid synthesis by human glioma
Journal of the Neurological Sciences, 1990Biopsy material from human gliomas obtained during neurosurgery was used to investigate whether pathological human brain tissue is capable of producing kynurenic acid (KYNA), a natural brain metabolite which can act as an antagonist at excitatory amino acid receptors.
Vezzani, A +5 more
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Journal of Neural Transmission, 2009
Kynurenic acid is an endogenous product of the tryptophan metabolism, and as a broad-spectrum antagonist of excitatory amino acid receptors may serve as a protective agent in neurological disorders. The use of kynurenic acid as a neuroprotective agent is rather limited, however, because it has only restricted ability to cross the blood-brain barrier ...
Marosi Máté Gábor +8 more
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Kynurenic acid is an endogenous product of the tryptophan metabolism, and as a broad-spectrum antagonist of excitatory amino acid receptors may serve as a protective agent in neurological disorders. The use of kynurenic acid as a neuroprotective agent is rather limited, however, because it has only restricted ability to cross the blood-brain barrier ...
Marosi Máté Gábor +8 more
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KYNURENIC ACID — II. PHOTOSENSITIZING PROPERTIES
Photochemistry and Photobiology, 1979Abstract— The photosensitizing properties of kynurenic acid have been studied by 353 nm laser flash spectroscopy and steady state irradiations. Laser flash spectroscopy indicates that the kynurenic acid triplet is reduced by amino acids and nucleic acid bases. Photoreactions implying singlet oxygen formation are shown to occur.
M. P. Pileni, M. Giraud, R. Santus
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