Results 231 to 240 of about 19,477 (272)

Kynurenic acid synthesis by human glioma

Journal of the Neurological Sciences, 1990
Biopsy material from human gliomas obtained during neurosurgery was used to investigate whether pathological human brain tissue is capable of producing kynurenic acid (KYNA), a natural brain metabolite which can act as an antagonist at excitatory amino acid receptors.
Vezzani, A, Gramsbergen, J B, Versari, P, Stasi, M A, Procaccio, F, Schwarcz, R   +5 more
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Presence of Kynurenic Acid in the Mammalian Brain

Journal of Neurochemistry, 1988
AbstractKynurenic acid, a tryptophan metabolite able to antagonize the actions of the excitatory amino acids, has been identified and measured for the first time in the brain of mice, rats, guinea pigs, and humans by using an HPLC method. Its content was 5.8 ± 0.9 in mouse brain, 17.8 ± 2.0 in rat brain, 16.2 ± 1.5 in guinea pig brain, 26.8 ± 2.9 in ...
MORONI F, RUSSI P, BENI M, CARLA’ V., LOMBARDI, Grazia   +4 more
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On the toxicity of kynurenic acid in vivo and in vitro

Pharmacological Reports, 2014
Kynurenic acid (KYNA), a tryptophan metabolite is an antagonist of ionotropic glutamate receptors and alpha-7 nicotinic receptor. Moreover, it is an agonist of G-protein receptor GPR35. Its neuroprotective, anticonvulsant, anti-inflammatory and antioxidant activity was documented. KYNA is present in food and herbal medicines.
Waldemar A. Turski, Joanna Małaczewska, Sebastian Marciniak, Jerzy Bednarski, Michał P. Turski, Mirosław Jabłoński, Andrzej K. Siwicki   +6 more
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Kynurenic acid actions in brain and periphery

International Congress Series, 2007
Abstract. Kynurenic acid (KYNA) is commonly considered a non-competitive NMDA receptor antagonist. It has been recently shown that KYNA also antagonizes the alpha 7 nicotine receptors and reduces glutamate and dopamine release in the rat striatum. Finally, it has been demonstrated that KYNA interacts with GPR35, an orphan receptor negatively coupled ...
MORONI, FLAVIO, S. Fossati, CHIARUGI, ALBERTO, COZZI, ANDREA   +3 more
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Presence and content of kynurenic acid in animal feed [PDF]

Journal of Animal Physiology and Animal Nutrition, 2014
SummaryKynurenic acid (KYNA) was found to be an antagonist of iontropic glutamate receptors and alpha7 nicotinic acetylcholine receptors. Furthermore, it was documented thatKYNAis an agonist ofG‐protein coupledGPR35 receptors which are mainly present in the gastrointestinal tract.
Wojciech Zgrajka, Michal P. Turski, Piotr Paluszkiewicz, Andrzej K. Siwicki   +3 more
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Modifications on the carboxylic function of kynurenic acid

Journal of Neural Transmission, 2011
Pharmacological and histological studies of ten new amides of kynurenic acid revealed that N-(2-N,N-dimethylaminoethyl)-4-oxo-1H-quinoline-2-carboxamide hydrochloride has effective neuroprotective properties. Namely, this molecule is: (1) proved to be an effective inhibitor of excitatory synaptic transmission in the CA1 region of the hippocampus both ...
Fülöp Ferenc, Szatmári István, Toldi József, Vécsei László   +3 more
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Antagonism of kynurenic acid to anxiogens in mice

Life Sciences, 1998
In a dark-light chamber in mice, kynurenic acid (KYNA, 200 mg/kg, i.p.), an endogenous neuroactive metabolite of tryptophan, attenuated the most stable effect of anxiogens in this model of anxiety--a decrease in the rate of leanings-out of the dark compartment --induced by caffeine, pentylenetetrazole and yohimbine, but not by beta-phenylethylamine ...
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Quinolinic Acid and Kynurenic Acid in the Mammalian Brain

1991
Over the last decade, the study of neuroexcitatory amino acids has become one of the most rapidly expanding areas of neuroscientific research. Interest in this class of compounds was precipitated mainly by the realization that metabolites such as glutamate and aspartate are major neurotransmitters in the central nervous system (Fonnum, 1984; Erecinska ...
F. Du, Robert Schwarcz
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Neuropharmacology of quinolinic and kynurenic acids.

Pharmacological Reviews, 1993
In a little more than 10 years, the kynurenine metabolites of tryptophan have emerged from their former position as biochemical curiosities, to occupy a prominent position in research on the causes and treatment of several major CNS disorders. The pathway includes two compounds, quinolinic acid and kynurenic acid, which are remarkably specific in their
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Production of Quinolinic Acid and Kynurenic Acid by Human Glioma

1991
Using biochemical and immunohistochemical techniques, the biosynthesis of the excitotoxin quinolinic acid (QUIN) and the anti-excitotoxin kynurenic acid (KYNA) in the rat brain has been demonstrated to take place preferentially in glial cells (see Schwarcz and Du, this volume, for review). Although a dysfunction of either of these two brain metabolites
Vezzani, A, Gramsbergen, J B, Speciale, C, Schwarcz, R   +3 more
openaire   +4 more sources