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KYNURENIC ACID — II. PHOTOSENSITIZING PROPERTIES
Photochemistry and Photobiology, 1979Abstract— The photosensitizing properties of kynurenic acid have been studied by 353 nm laser flash spectroscopy and steady state irradiations. Laser flash spectroscopy indicates that the kynurenic acid triplet is reduced by amino acids and nucleic acid bases. Photoreactions implying singlet oxygen formation are shown to occur.
Michel Giraud +2 more
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Synthesis of New Substituted Kynurenic Acids
Organic Preparations and Procedures International, 2017Kynurenic acid (4-hydroxyquinoline-2-carboxylic acid) and its derivatives play a crucial role in maintaining normal brain function.1 Several kynurenic acid derivatives containing halo, amino, hydro...
Ajoy K. Banerjee, William J. Vera
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Developmental changes in brain kynurenic acid concentrations
Developmental Brain Research, 1992The cerebral distribution and regulation of excitatory amino acid levels may play a crucial role in neuronal development. In the present study we examined concentrations of the endogenous excitatory amino acid antagonist kynurenic acid and related substances during development in fetal and neonatal rat brain and fetal non-human primate cerebral cortex.
M. Flint Beal +2 more
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Distribution, Synthesis, and Absorption of Kynurenic Acid in Plants
Planta Medica, 2010Kynurenic acid (KYNA) is an endogenous antagonist of the ionotropic glutamate receptors and the α7 nicotinic acetylcholine receptor as well as an agonist of the G-protein-coupled receptor GPR35. In this study, KYNA distribution and synthesis in plants as well as its absorption was researched.
Michal P. Turski +5 more
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Journal of Pharmaceutical and Biomedical Analysis, 2011
The changes in concentration of kynurenic acid (KYNA) in different biological samples are of great interest in the pathomechanism and medication of several disorders, and especially those affecting the nervous system. Besides the recent pharmaceutical advances targeting the kynurenine pathway, there is a constant need for further drug development ...
Zádori Dénes +7 more
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The changes in concentration of kynurenic acid (KYNA) in different biological samples are of great interest in the pathomechanism and medication of several disorders, and especially those affecting the nervous system. Besides the recent pharmaceutical advances targeting the kynurenine pathway, there is a constant need for further drug development ...
Zádori Dénes +7 more
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Tautomeric polymorphism of the neuroactive inhibitor kynurenic acid
Acta Crystallographica Section C Structural Chemistry, 2019Kynurenic acid (KYN; systematic name: 4-hydroxyquinoline-2-carboxylic acid, C10H7NO3) displays a therapeutic effect in the treatment of some neurological diseases and is used as a broad-spectrum neuroprotective agent. However, it is understudied with respect to its solid-state chemistry and only one crystal form (α-KYN·H2O) has been reported up to now.
Jan Janczak +4 more
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Neuroprotective potency of kynurenic acid against excitotoxicity
NeuroReport, 2000The aim of this study was to determine in vivo which extracellular levels of kynurenic acid (KYNA) are required to control excessive NMDA receptor activation in the rat cortex. As excitotoxicity is coupled to marked ion movements, local depolarisations induced by perfusion of NMDA or quinolinic acid (QUIN) through microdialysis probes were recorded at ...
Jutta Urenjak, Tihomir P. Obrenovitch
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ON THE EXCRETION OF KYNURENIC ACID
American Journal of Physiology-Legacy Content, 1898Holmes C. Jackson, Lafayette B. Mendel
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Kynurenic acid in ALS patients
Acta Neurologica Scandinavica, 2004Joe Aoyagi +10 more
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