Kynurenic acid - Open Access .click

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Ideggyogyaszati szemle, 2003
It is well known that glutamate receptors have significant role in the pain transmission. The activation of N-methyl-D-aspartate receptors causes persistent pain, therefore the antagonists acting on these receptors cause antinociception in chronic pain states.
Gabriella, Kékesi, Gyöngyi, Horváth
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Neuropharmacology of quinolinic and kynurenic acids.

Pharmacological Reviews, 1993
In a little more than 10 years, the kynurenine metabolites of tryptophan have emerged from their former position as biochemical curiosities, to occupy a prominent position in research on the causes and treatment of several major CNS disorders. The pathway includes two compounds, quinolinic acid and kynurenic acid, which are remarkably specific in their
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Some central effects of kynurenic acid, 7-chlorokynurenic acid and 5,7- dichloro-kynurenic acid, glycine site antagonists.

Polish journal of pharmacology, 1995
Strychnine-insensitive glycine site is one of a few binding sites of NMDA receptor complex. The aim of these study was to find out whether compounds regarded as glycine antagonists-kynurenic acid (KA), 7-chlorokynurenic acid (7-CKA), 5,7-dichlorokynurenic acid (5,7-DCKA) evoke the effects analogous to those of the NMDA receptor antagonist, CGP 37849 ...
J, Maj +3 more
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Kynurenic acid in ALS patients