Results 251 to 260 of about 5,018,081 (294)

Influence of plasma cytokines on kynurenine and kynurenic acid in schizophrenia

Neuropsychopharmacology, 2018
J. Chiappelli, F. Notarangelo, Ana Pocivavsek, Marian A. R. Thomas, Laura M. Rowland, R. Schwarcz, L. E. Hong   +6 more
semanticscholar   +1 more source

Ortho-quinone methide driven synthesis of kynurenic acid lactams. [PDF]

RSC Adv
Sárik JR, Hetényi A, Berkecz R, Szatmári I, Lőrinczi B.   +4 more
europepmc   +1 more source

Evaluation of solubility enhancement, antioxidant activity, and cytotoxicity studies of kynurenic acid loaded cyclodextrin nanosponge.

Carbohydrate Polymers, 2019
N. Dhakar, F. Caldera, F. Bessone, Claudio Cecone, Alberto Rubin Pedrazzo, R. Cavalli, C. Dianzani, F. Trotta   +7 more
semanticscholar   +1 more source

The Impact of C-3 Side Chain Modifications on Kynurenic Acid: A Behavioral Analysis of Its Analogs in the Motor Domain. [PDF]

Int J Mol Sci
Martos D, Lőrinczi B, Szatmári I, Vécsei L, Tanaka M.   +4 more
europepmc   +1 more source

Fetal Sex as Moderating Factor for the Relationship Between Maternal Childhood Trauma and Salivary Kynurenic Acid and Tryptophan in Pregnancy: A Pilot Study. [PDF]

Int J Tryptophan Res
Pedraz-Petrozzi B, Lamadé EK, Marszalek-Grabska M, Trzpil A, Lindner O, Meininger P, Fornal E, Turski WA, Witt SH, Gilles M, Deuschle M.   +10 more
europepmc   +1 more source

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A review of chromatographic methods for bioactive tryptophan metabolites, kynurenine, kynurenic acid, quinolinic acid, and others, in biological fluids.

Biomedical chromotography, 2022
sKynurenine (KYN) is synthesized from an essential amino acid, tryptophan by tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase via N-formyl- KYN in vivo. Subsequently, KYN acts as a precursor of some neuroactive metabolites such as kynurenic acid,
T. Fukushima, Maho Umino, Tatsuya Sakamoto, Mayu Onozato   +3 more
semanticscholar   +1 more source

Comparative study on the effects of kynurenic acid and glucosamine–kynurenic acid [PDF]

Pharmacology Biochemistry and Behavior, 2004
Kynurenic acid (KYNA) is the only known endogenous N-methyl-D-aspartate (NMDA) receptor inhibitor and might therefore come into consideration as a therapeutic agent in certain neurobiological disorders. However, its use as a neuroprotective compound is practically excluded because KYNA does not readily cross the blood-brain barrier (BBB).
Tamás Farkas, László Vécsei, László Vécsei, Judit Füvesi, Zsuzsa Penke, József Toldi, Hajnalka Németh, Csaba Somlai, Márton B. Dobszay, Zsolt Kis, Norbert Károly, Hedvig Varga, Hedvig Varga, Botond Penke   +13 more
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The Janus-face kynurenic acid

Journal of Neural Transmission, 2008
Kynurenic acid is an endogenous product of the tryptophan metabolism. Studies on the mechanism of its action have revealed that kynurenic acid at high concentrations is a competitive antagonist of the N-methyl-D-aspartate receptor and acts as a neuroprotectant in different neurological disorders.
Rózsa Éva, Robotka Hermina, Vécsei László, Toldi József   +3 more
openaire   +4 more sources