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The kynurenic acid hypothesis of schizophrenia
Physiology & Behavior, 2007In recent years progress in the field of schizophrenia research has led to the suggestion that dopamine only plays an intermediary role in the pathophysiology of the disease and that the main abnormalities lie elsewhere. In particular, deficits in brain glutamatergic systems are suggested to play a prominent role in the pathophysiology of the disease ...
Sophie Erhardt +4 more
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Acta Crystallographica Section C Crystal Structure Communications, 1996
In the structure of the title compound, 4-hydroxy-2- quinolinecarboxylic acid monohydrate, C 10 H 7 NO 3 .H 2 O, the carboxyl group is ionized and the ring N atom is protonated giving it a positive charge. The molecule is almost planar. The crystal structure is stabilized both by intermolecular O-H...O and N-H...O hydrogen bonds involving the solvated ...
N. Okabe, J. Miura, A. Shimosaki
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In the structure of the title compound, 4-hydroxy-2- quinolinecarboxylic acid monohydrate, C 10 H 7 NO 3 .H 2 O, the carboxyl group is ionized and the ring N atom is protonated giving it a positive charge. The molecule is almost planar. The crystal structure is stabilized both by intermolecular O-H...O and N-H...O hydrogen bonds involving the solvated ...
N. Okabe, J. Miura, A. Shimosaki
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Kynurenic Acid And Schizophrenia
2003In recent years the "dopamine (DA) hypothesis of schizophrenia", has been modified into a more diversified view where an attenuated glutamatergic neurotransmission is believed to participate in the pathogenesis of the disease. Thus, schizophrenia may be regarded as a glutamate deficiency disorder.
Sophie Erhardt +2 more
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Journal of Cellular Physiology, 2020
Endoplasmic reticulum (ER) stress plays a causative role in the development of nonalcoholic fatty liver disease (NAFLD). Kynurenic acid (KA) is a tryptophan metabolite that has been shown to exert anti‐inflammatory effects in macrophages and endothelial ...
Do Hyeon Pyun +6 more
semanticscholar +1 more source
Endoplasmic reticulum (ER) stress plays a causative role in the development of nonalcoholic fatty liver disease (NAFLD). Kynurenic acid (KA) is a tryptophan metabolite that has been shown to exert anti‐inflammatory effects in macrophages and endothelial ...
Do Hyeon Pyun +6 more
semanticscholar +1 more source
Journal of Neural Transmission, 2009
Kynurenic acid is an endogenous product of the tryptophan metabolism, and as a broad-spectrum antagonist of excitatory amino acid receptors may serve as a protective agent in neurological disorders. The use of kynurenic acid as a neuroprotective agent is rather limited, however, because it has only restricted ability to cross the blood-brain barrier ...
Marosi Máté Gábor +8 more
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Kynurenic acid is an endogenous product of the tryptophan metabolism, and as a broad-spectrum antagonist of excitatory amino acid receptors may serve as a protective agent in neurological disorders. The use of kynurenic acid as a neuroprotective agent is rather limited, however, because it has only restricted ability to cross the blood-brain barrier ...
Marosi Máté Gábor +8 more
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Kynurenic acid synthesis by human glioma
Journal of the Neurological Sciences, 1990Biopsy material from human gliomas obtained during neurosurgery was used to investigate whether pathological human brain tissue is capable of producing kynurenic acid (KYNA), a natural brain metabolite which can act as an antagonist at excitatory amino acid receptors.
Vezzani, A +5 more
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Presence of Kynurenic Acid in the Mammalian Brain
Journal of Neurochemistry, 1988AbstractKynurenic acid, a tryptophan metabolite able to antagonize the actions of the excitatory amino acids, has been identified and measured for the first time in the brain of mice, rats, guinea pigs, and humans by using an HPLC method. Its content was 5.8 ± 0.9 in mouse brain, 17.8 ± 2.0 in rat brain, 16.2 ± 1.5 in guinea pig brain, 26.8 ± 2.9 in ...
MORONI F +4 more
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An efficient method for production of kynurenic acid by Yarrowia lipolytica
Yeast, 2020Kynurenic acid (KYNA) is a compound derived from the tryptophan catabolic pathway. Antioxidant and neuroprotective properties have been confirmed for KYNA, which makes it an interesting and important metabolite of biomedical significance.
M. Wróbel-Kwiatkowska +4 more
semanticscholar +1 more source
Modifications on the carboxylic function of kynurenic acid
Journal of Neural Transmission, 2011Pharmacological and histological studies of ten new amides of kynurenic acid revealed that N-(2-N,N-dimethylaminoethyl)-4-oxo-1H-quinoline-2-carboxamide hydrochloride has effective neuroprotective properties. Namely, this molecule is: (1) proved to be an effective inhibitor of excitatory synaptic transmission in the CA1 region of the hippocampus both ...
Fülöp Ferenc +3 more
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On the toxicity of kynurenic acid in vivo and in vitro
Pharmacological Reports, 2014Kynurenic acid (KYNA), a tryptophan metabolite is an antagonist of ionotropic glutamate receptors and alpha-7 nicotinic receptor. Moreover, it is an agonist of G-protein receptor GPR35. Its neuroprotective, anticonvulsant, anti-inflammatory and antioxidant activity was documented. KYNA is present in food and herbal medicines.
Waldemar A. Turski +6 more
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