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Kynurenic acid actions in brain and periphery
International Congress Series, 2007Abstract. Kynurenic acid (KYNA) is commonly considered a non-competitive NMDA receptor antagonist. It has been recently shown that KYNA also antagonizes the alpha 7 nicotine receptors and reduces glutamate and dopamine release in the rat striatum. Finally, it has been demonstrated that KYNA interacts with GPR35, an orphan receptor negatively coupled ...
MORONI, FLAVIO +3 more
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Antagonism of kynurenic acid to anxiogens in mice
Life Sciences, 1998In a dark-light chamber in mice, kynurenic acid (KYNA, 200 mg/kg, i.p.), an endogenous neuroactive metabolite of tryptophan, attenuated the most stable effect of anxiogens in this model of anxiety--a decrease in the rate of leanings-out of the dark compartment --induced by caffeine, pentylenetetrazole and yohimbine, but not by beta-phenylethylamine ...
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Quinolinic Acid and Kynurenic Acid in the Mammalian Brain
1991Over the last decade, the study of neuroexcitatory amino acids has become one of the most rapidly expanding areas of neuroscientific research. Interest in this class of compounds was precipitated mainly by the realization that metabolites such as glutamate and aspartate are major neurotransmitters in the central nervous system (Fonnum, 1984; Erecinska ...
F. Du, Robert Schwarcz
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KYNURENIC ACID — II. PHOTOSENSITIZING PROPERTIES
Photochemistry and Photobiology, 1979Abstract— The photosensitizing properties of kynurenic acid have been studied by 353 nm laser flash spectroscopy and steady state irradiations. Laser flash spectroscopy indicates that the kynurenic acid triplet is reduced by amino acids and nucleic acid bases. Photoreactions implying singlet oxygen formation are shown to occur.
Michel Giraud +2 more
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Synthesis of New Substituted Kynurenic Acids
Organic Preparations and Procedures International, 2017Kynurenic acid (4-hydroxyquinoline-2-carboxylic acid) and its derivatives play a crucial role in maintaining normal brain function.1 Several kynurenic acid derivatives containing halo, amino, hydro...
Ajoy K. Banerjee, William J. Vera
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Production of Quinolinic Acid and Kynurenic Acid by Human Glioma
1991Using biochemical and immunohistochemical techniques, the biosynthesis of the excitotoxin quinolinic acid (QUIN) and the anti-excitotoxin kynurenic acid (KYNA) in the rat brain has been demonstrated to take place preferentially in glial cells (see Schwarcz and Du, this volume, for review). Although a dysfunction of either of these two brain metabolites
Vezzani, A +3 more
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Developmental changes in brain kynurenic acid concentrations
Developmental Brain Research, 1992The cerebral distribution and regulation of excitatory amino acid levels may play a crucial role in neuronal development. In the present study we examined concentrations of the endogenous excitatory amino acid antagonist kynurenic acid and related substances during development in fetal and neonatal rat brain and fetal non-human primate cerebral cortex.
M. Flint Beal +2 more
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Neuroprotective potency of kynurenic acid against excitotoxicity
NeuroReport, 2000The aim of this study was to determine in vivo which extracellular levels of kynurenic acid (KYNA) are required to control excessive NMDA receptor activation in the rat cortex. As excitotoxicity is coupled to marked ion movements, local depolarisations induced by perfusion of NMDA or quinolinic acid (QUIN) through microdialysis probes were recorded at ...
Jutta Urenjak, Tihomir P. Obrenovitch
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Tautomeric polymorphism of the neuroactive inhibitor kynurenic acid
Acta Crystallographica Section C Structural Chemistry, 2019Kynurenic acid (KYN; systematic name: 4-hydroxyquinoline-2-carboxylic acid, C10H7NO3) displays a therapeutic effect in the treatment of some neurological diseases and is used as a broad-spectrum neuroprotective agent. However, it is understudied with respect to its solid-state chemistry and only one crystal form (α-KYN·H2O) has been reported up to now.
Jan Janczak +4 more
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Biomedical chromotography, 2018
Reliable methods for the determination of tryptophan and its metabolites are vital to the monitoring of biochemical states during the initiation and progression of cardiovascular disease.
Q. Tong +5 more
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Reliable methods for the determination of tryptophan and its metabolites are vital to the monitoring of biochemical states during the initiation and progression of cardiovascular disease.
Q. Tong +5 more
semanticscholar +1 more source