Results 91 to 100 of about 23,526 (258)

Weizmannia coagulans XY2 Mitigates Copper Neurotoxicity via Gut–Brain Axis Modulation of Tryptophan Metabolism and Oxidative‐Inflammatory Crosstalk

iMetaOmics, EarlyView.
Copper interferes with tryptophan metabolism and 5‐HT levels by modulating intestinal flora. Intestinal barrier breakdown and inflammatory response trigger nerve damage under copper exposure. W. coagulans XY2 alleviates copper‐induced neurotoxicity by targeting a multi‐dimensional “tryptophan metabolism‐antioxidant defense‐gut‐brain axis” network.
Yufang Gao, Xiaodong Zheng, Fujie Yan
wiley   +1 more source

Impact of Substance Use Disorder on Tryptophan Metabolism Through the Kynurenine Pathway: A Narrative Review

Metabolites
Background/Objectives: Substance use disorder is a crisis impacting many people in the United States. This review aimed to identify the effect addictive substances have on the kynurenine pathway.
Lindsey Contella, Christopher L. Farrell, Luigi Boccuto, Alain H. Litwin, Marion L. Snyder   +4 more
doaj   +1 more source

THU625 Med12 Mutation Activates Tryptophan-Kynurenine-ahr Pathway To Promote Growth Of Uterine Leiomyoma

, 2023
Azna Zuberi, Yongchao Huang, Ariel J. Dotts, Helen Wei, John S. Coon, Takashi Lizuka, Olívia Wu, Olivia Sotos, Debabrata Chakravarti, Yang Dai, Serdar E. Bulun, Ping Yin   +11 more
openalex   +1 more source

Impact of Alcohol Intake on Parkinson's Disease Risk and Progression: A Systematic Review and Dose–Response Meta‐Analysis of Prospective Studies

Movement Disorders, EarlyView.
Abstract The association between alcohol consumption and Parkinson's disease (PD) risk remains unclear, whereas smoking has an inverse relationship with the disease. This study systematically reviewed and meta‐analyzed 16 studies (2014–2024) from PubMed, Scopus, Web of Science, MEDLINE, and the Cochrane Library to assess the relationship between ...
Sahar Hemeda, Mohammed Elmadani, Mohammed Merzah, Aseel Odeh, Evelyn Pintér, István Balás, József Janszky, Dávid Pintér, Norbert Kovács   +8 more
wiley   +1 more source

Plasma tryptophan- kynurenine pathway metabolites and risk for progression to end stage kidney disease in patients with type 2 diabetes

, 2023
Jianjun Liu, Jianhong Ching, Hai Ning Wee, Sylvia Liu, Resham L Gurung, Janus Lee, M Yiamunaa, Huili Zheng, Lye Siang Lee, Keven Ang, Yi Ming Shao, Jean‐Paul Kovalik, Tavintharan Subramaniam, Chee Fang Sum, Kumar Sharma, Bryan Kestenbaum, Su Chi Lim   +16 more
openalex   +1 more source

Altered Cerebrospinal Fluid Tryptophan–Kynurenine Pathway Metabolism in Multiple System Atrophy

Movement Disorders, EarlyView.
Abstract Background Alterations in tryptophan–kynurenine (TRP‐KYN) metabolism, which is associated with neuroinflammation, remain unclear in multiple system atrophy (MSA). Objective The aim was to investigate cerebrospinal fluid (CSF) TRP metabolites in MSA and their associations with other biomarkers.
Ryunosuke Nagao, Kazuya Kawabata, Yasuaki Mizutani, Sayuri Shima, Akihiro Ueda, Mizuki Ito, Yasuhiro Maeda, Akihiro Mouri, Hirohisa Watanabe   +8 more
wiley   +1 more source

Genetically predicted KIR2DS4 mediate the association between gut microbe K10 and osteoporosis fractures: A mediation Mendelian randomization study

PM&R, EarlyView.
Abstract Background Osteoporosis fractures pose a significant public health concern, leading to substantial morbidity and mortality rates. The emerging evidence on the potential link between gut microbiota, proteins, and osteoporosis fractures suggests a complex relationship that warrants further investigation.
Qiong Wang, Qing Kuang, Cheng Chen, Binru Wang, Wei Xiang, Xinming Li, Jianjiao Mou   +6 more
wiley   +1 more source

From Membrane Composition to Antimicrobial Strategies: Experimental and Computational Approaches to AMP Design and Selectivity

Small, EarlyView.
Antimicrobial peptides (AMPs) are promising candidates for next‐generation antibiotics, acting through mechanisms such as membrane disruption and intracellular targeting. This review examines how variations in bacterial membrane composition critically influence AMP activity.
Paolo Rossetti, Marius F.W. Trollmann, Christina Wichmann, Thomas Gutsmann, Christian Eggeling, Rainer A. Böckmann   +5 more
wiley   +1 more source

Neopterin and Kynurenine in Mesangioproliferative Glomerulonephritis

Pteridines, 1998
Serum kynurenine and neopterin concentrations were determined in patients with chronic mesangioproliferative glomerulonephritis with normal renal function and in patients with chronic renal failure. Significantly increased kynurenine and neopterin levels
Martinsons Agris, Rudzite Vera, Widner Bernhard, Fuchs Dietmar   +3 more
doaj   +1 more source

The Kynurenine Pathway in Stem Cell Biology

International Journal of Tryptophan Research, 2013
The kynurenine pathway (KP) is the main catabolic pathway of the essential amino acid tryptophan. The KP has been identified to play a critical role in regulating immune responses in a variety of experimental settings. It is also known to be involved in several neuroinflammatory diseases including Huntington's disease, amyotrophic lateral sclerosis ...
Jones, Simon P., Guillemin, Gilles J., Brew, Bruce J.   +2 more
openaire   +2 more sources