Results 111 to 120 of about 23,526 (258)

Kynurenine monooxygenase BcKMOL: a key regulator of growth, pathogenicity, and disease control in Botrytis cinerea

Frontiers in Microbiology
Kynurenine monooxygenase, a vital rate-limiting enzyme in the kynurenine pathway metabolic branch, has shown promise as a drug target for treating human neurodegenerative diseases.
Bai Li, Bai Li, Xiaoying Liu, Jinping Zang, Hongzhe Cao, Helong Si, Kang Zhang, Kang Zhang, Jihong Xing, Jihong Xing, Jingao Dong, Jingao Dong   +11 more
doaj   +1 more source

Beyond nocardioform: Transcriptionally active microbes and host responses in equine mucoid placentitis

Equine Veterinary Journal, EarlyView.
Abstract Background Nocardioform placentitis (NP) is an understudied form of equine placentitis historically attributed to nocardioform bacteria, yet it remains uncertain whether these organisms are the sole pathogens involved. Objectives To elucidate the pathophysiology of NP and the host–pathogen interaction. Study Design In vivo clinical multi‐omics
Machteld van Heule, Margo Verstraete, Jamie Kaj Norris, Kinga Barbara Graniczkowsa, Kirsten E. Scoggin, Hossam El‐Sheikh Ali, Barry A. Ball, Ward De Spiegelaere, Peter Daels, Bart C. Weimer, Pouya Dini   +10 more
wiley   +1 more source

Sex- and suicide-specific alterations in the kynurenine pathway in the anterior cingulate cortex in major depression [PDF]

, 2023
Samara Brown, Katerina Christofides, Christin Weissleder, Xu‐Feng Huang, Cynthia Shannon Weickert, Chai K. Lim, Kelly A. Newell   +6 more
openalex   +1 more source

Targeting the microbiota‐miRNA‐protease axis: A new therapeutic avenue in melanoma

The FEBS Journal, EarlyView.
Modulation of extracellular matrix (ECM) turnover is central to melanoma progression and metastasis, driven largely by ECM proteases. This review highlights the epigenetic regulation of ECM proteases by microRNAs and their roles in melanoma growth, invasion, and immune modulation.
Elias N. Katsoulieris, Paraskevi Ioannou, Nikolaos A. Afratis   +2 more
wiley   +1 more source

Tryptophan‐Derived Microbial Metabolite Indole‐3‐Acetic Acid Ameliorates Periodontitis Through AhR/CYP1A1‐Mediated Macrophage Polarisation

Journal of Clinical Periodontology, EarlyView.
ABSTRACT Aim To investigate the association between tryptophan‐derived microbial metabolites and periodontitis, and to assess whether the differential tryptophan metabolite indole‐3‐acetic acid (IAA) could ameliorate periodontitis and elucidate its potential mechanism.
Shuyu Cheng, Shiyuan Song, Wen Zhang, Dan Qiao, Min Wang, Zhifeng Wang, Jiajie Pu, Wenrong Yang, Fuhua Yan, Yangheng Zhang   +9 more
wiley   +1 more source

Resistance Exercise Reduces Kynurenine Pathway Metabolites in Breast Cancer Patients Undergoing Radiotherapy [PDF]

, 2019
Philipp Zimmer, Martina E. Schmidt, Mirja Tamara Prentzell, Bianca Berdel, Joachim Wiskemann, Karl Heinz Kellner, Jürgen Debus, Cornelia M. Ulrich, Christiane A. Opitz, Karen Steindorf   +9 more
openalex   +1 more source

Gestational kynurenine metabolites mediate effects of pregnancy adiposity on child negative affect

Journal of Child Psychology and Psychiatry, EarlyView.
Background Mounting evidence links increased adiposity during pregnancy and offspring risk for mental health disorders. Yet the mechanisms underlying this association remain poorly understood, limiting our ability to design effective interventions.
Hanna C. Gustafsson, Hanna R. Wright, Jorden E. Jacinto Schreeder, Joel T. Nigg, Elinor L. Sullivan   +4 more
wiley   +1 more source

The Double‐Edged Sword of Gestational Insulin Resistance: Navigating Maternal Adaptation and Its Risks for Pregnancy and Offspring Health

Obesity Reviews, EarlyView.
ABSTRACT Although much research focuses on the effects of hyperglycemia during pregnancy on maternal and offspring health, this narrative review specifically centers on the role of insulin resistance (IR) in pregnancy complications and offspring long‐term health.
Runyu Du, Fei Wang, Ling Li, Qiuyue Wang
wiley   +1 more source

OsPT4 Facilitates Selenomethionine Transport and Biosynthesis to Enhance Seed Accumulation in Rice: Molecular Mechanisms and Biotechnological Potential

Plant Biotechnology Journal, EarlyView.
ABSTRACT Selenium (Se) is a vital micronutrient for humans, with important functions for health and anti‐cancer properties. Organic Se shows higher antioxidant activity and much lower toxicity compared to inorganic Se, making it safer for use. Selenomethionine (SeMet) is one of the primary forms of organic Se.
Yang Yang, Lijuan Sun, Jia Wei, Fang Zhang, Shiyan Yang, Jiarui Zhang, Qin Qin, Jun Wang, Guohua Xu, Shubin Sun, Yafei Sun, Yong Xue   +11 more
wiley   +1 more source

Exercise training impacts skeletal muscle gene expression related to the kynurenine pathway [PDF]

, 2019
David J. Allison, Joshua P. Nederveen, Tim Snijders, Kirsten E. Bell, Dinesh Kumbhare, Stuart M. Phillips, Gianni Parise, Jennifer J. Heisz   +7 more
openalex   +1 more source