Results 111 to 120 of about 34,492 (275)

Identification of biomarkers of colitis to monitor effects of dietary omega-3 polyunsaturated fatty acids in the interleukin-10 gene-deficient mouse model of inflammatory bowel diseases : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Nutritional Science at Massey University, Manawatū, New Zealand [PDF]

, 2016
Inflammatory bowel diseases (IBD) are characterised by chronic inflammation of the gastrointestinal tract including the colon (colitis). Increased dietary intake of salmon, which is rich in eicosapentaenoic acid (EPA), was well tolerated by IBD patients,
Berger, Nadja
core  

Intestinal microbiome alterations in pediatric epilepsy: Implications for seizures and therapeutic approaches

Epilepsia Open, EarlyView.
Abstract The intestinal microbiome plays a pivotal role in maintaining host health through its involvement in gastrointestinal, immune, and central nervous system (CNS) functions. Recent evidence underscores the bidirectional communication between the microbiota, the gut, and the brain and the impact of this axis on neurological diseases, including ...
Teresa Ravizza, Greta Volpedo, Antonella Riva, Pasquale Striano, Annamaria Vezzani   +4 more
wiley   +1 more source

Kynurenine pathway metabolism and the microbiota-gut-brain axis [PDF]

, 2018
It has become increasingly clear that the gut microbiota influences not only gastrointestinal physiology but also central nervous system (CNS) function by modulating signalling pathways of the microbiota-gut-brain axis.
Clarke, Gerard, Cryan, John F., Dinan, Timothy G., Kennedy, Paul J.   +3 more
core   +1 more source

Alterations and mechanistic insights of gut microbiota and its metabolites in type 2 diabetes mellitus and Alzheimer's disease

iMetaOmics, EarlyView.
This narrative review uniquely addresses how gut microbiota‐derived metabolites mediate overlapping pathologies of insulin resistance, neuroinflammation, and amyloidogenesis in type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD), proposing a framework for dual therapeutic targeting.
Guangyi Xu, Yu An, Yage Du, Zhaoming Cao, Jie Zheng, Jingya Wang, Tingyi Li, Xingen Lei, Yanhui Lu   +8 more
wiley   +1 more source

Kynurenine and serotonin pathways: A review

Bayero Journal of Pure and Applied Sciences, 2013
This paper seeks to elucidate the two-key pathways involving tryptophan matabolism, namely, kynurenine and serotonin pathways. In the kynurenine pathway (KP), the discussion considers the steps of the oxidative degradation of tryptophan to yield nicotinate mononucleotide, a precursors for the biosynthesis of nicotinate nucleotides ( NAD+ and NADP ...
openaire   +3 more sources

Activation of the tryptophan/serotonin pathway is associated with severity and predicts outcomes in pneumonia: results of a long-term cohort study [PDF]

, 2017
As part of the immune defense during infection, an increase in enzyme activity of indoleamine 2,3-dioxygenase (IDO) leads to a breakdown of tryptophan to kynurenine.
Bernasconi, Luca, Christ-Crain, Mirjam, Henzen, Christoph, Hoess, Claus, Huber, Andreas, Meier, Marc A., Mueller, Beat, Ottiger, Manuel, Schuetz, Philipp, Steuer, Christian, Thomann, Robert, Vögeli, Alaadin, Zimmerli, Werner   +12 more
core   +1 more source

From multi‐omics to precision medicine in intracranial aneurysm: Biomarker discovery and multimodal integration

Interdisciplinary Medicine, EarlyView.
This review explores intracranial aneurysm biomarker discovery through multi‐omics. It reveals key genes, proteins, and metabolites, and shows how machine‐learning‐based multi‐modal integration may aid diagnosis and treatment. Abstract Despite extensive research, currently, no biomarkers are available for clinical use in intracranial aneurysm (IA ...
Jiaxin Zhang, Yufei Yang, Bingxu Chen, Yanmeng Zhao, Haitao Sun   +4 more
wiley   +1 more source

The mysterious case of the C. elegans gut granule: death fluorescence, anthranilic acid and the kynurenine pathway [PDF]

, 2013
Gut granules are lysosome-like organelles with acidic interiors that are found in large numbers within the intestine of the nematode Caenorhabditis elegans.
Coburn, C, Gems, D
core   +1 more source

The Kynurenine Pathway in Stem Cell Biology

International Journal of Tryptophan Research, 2013
The kynurenine pathway (KP) is the main catabolic pathway of the essential amino acid tryptophan. The KP has been identified to play a critical role in regulating immune responses in a variety of experimental settings. It is also known to be involved in several neuroinflammatory diseases including Huntington's disease, amyotrophic lateral sclerosis ...
Simon Jones, Bruce J. Brew, Bruce J. Brew, Gilles J. Guillemin   +3 more
openaire   +3 more sources

Combined Metabolomic Analysis of Plasma and Tissue Reveals a Prognostic Risk Score System and Metabolic Dysregulation in Esophageal Squamous Cell Carcinoma

Frontiers in Oncology, 2020
Background: Esophageal squamous cell carcinoma (ESCC) is a gastrointestinal malignancy with a poor prognosis. Although studies have shown metabolic reprogramming to be linked to ESCC development, no prognostic metabolic biomarkers or potential ...
Zhongjian Chen, Zhongjian Chen, Zhongjian Chen, Zhongjian Chen, Yalan Dai, Yalan Dai, Yalan Dai, Xiancong Huang, Xiancong Huang, Xiancong Huang, Keke Chen, Keke Chen, Keke Chen, Keke Chen, Yun Gao, Yun Gao, Yun Gao, Na Li, Na Li, Na Li, Ding Wang, Ding Wang, Ding Wang, Aiping Chen, Aiping Chen, Aiping Chen, Qingxia Yang, Yanjun Hong, Su Zeng, Weimin Mao, Weimin Mao, Weimin Mao   +31 more
doaj   +1 more source