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Kynurenine Pathway and Disease: An Overview
CNS & Neurological Disorders - Drug Targets, 2007Kynurenine pathway is gaining more and more attention every day in biomedical research since this catabolic route for tryptophan decomposition is not only implicated in different neurological disorders, but also possesses neuroactive metabolites with different biological properties, such as pro-oxidant and antioxidant regulators.
Verónica, Pérez-De La Cruz +2 more
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Pharmacology of the kynurenine pathway
International Congress Series, 2007Abstract The kynurenine pathway of tryptophan oxidative metabolism plays a major role in the nervous and immune systems and has been implicated in a range of disease states. Much of the interest in the pathway has been centred around the role of quinolinic acid as an agonist at glutamate receptors sensitive to N -methyl- d -aspartate (NMDA) and ...
Trevor W. Stone, L. Gail Darlington
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Kynurenine Pathway Metabolism in Human Astrocytes
1999The involvement of astrocytes in Kynurenine pathway (KP) metabolism is still poorly understood. In the present study, we investigated the ability of human fetal astrocytes in vitro to produce quinolinic and picolinic acids using mass spectrometry. In parallel, we estimated the level of expression of five major KP enzymes using RT-PCR.
G J, Guillemin +4 more
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[Stress and the kynurenine pathway].
Orvosi hetilap, 2015The kynurenine pathway is the main route of tryptophan degradation which gives rise to several neuroactive metabolites. Kynurenic acid is an endogenous antagonist of excitatory receptors, which proved to be neuroprotective in the preclinical settings. Kynurenines have been implicated in the neuroendocrine regulatory processes.
Majláth Zsófia, Vécsei László
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Kynurenine pathway changes in late-life depression
Journal of Affective Disorders, 2018Kynurenine pathway (KP) activation is associated with several neuropsychiatric diseases, including major depression disorder (MDD). Although several investigations have been conducted on MDD, these have seldom shed light on KP changes in late-life depression (LLD).We aimed to investigate whether tryptophan (TRP) metabolism and kynurenine (KYN ...
Yujie, Wu +8 more
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The Kynurenine Pathway in Brain Tumor Pathogenesis
Cancer Research, 2012AbstractBrain tumors are among the most common and most chemoresistant tumors. Despite treatment with aggressive treatment strategies, the prognosis for patients harboring malignant gliomas remains dismal. The kynurenine pathway (KP) is the principal route of l-tryptophan catabolism leading to the formation of the essential pyridine nucleotide ...
Seray, Adams +7 more
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Role of the Kynurenine Pathway in Stroke
2015Stroke is the second and fifth leading cause of death for people aged >60 and 15–59 years, respectively. Many stroke survivors suffer from chronic health problems that necessitate a long-term process of recovery and rehabilitation. There is increasing evidence that inflammation plays an important role in acute ischemic stroke (AIS), indicating the ...
Ormstad, Heidi, Verkerk, Robert
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Kynurenine Pathway Enzymes in Brain
1996The kynurenine pathway is the metabolic route by which the essential amino acid, L-tryptophan is catabolized to a number of metabolites for excretion and convertion to nicotinamide-containing nucleotides (Bender, 1982). The liver is viewed as the major source of kynurenine pathway metabolites in blood and urine.
K. Saito, M. P. Heyes
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Tryptophan Metabolism Along the Kynurenine Pathway in Rats
2003Enzyme activities along the kynurenine pathway, liver tryptophan 2,3-dioxygenase, small intestine indole 2,3-dioxygenase, liver and kidney kynurenine 3-monooxygenase, kynureninase, kynurenine-oxoglutarate transaminase, 3-hydroxyanthranilate 3,4-dioxygenase, and aminocarboxymuconate-semialdehyde decarboxylase, involved in the catabolism of tryptophan ...
ALLEGRI, GRAZIELLA +4 more
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Kynurenic acid antagonists and kynurenine pathway inhibitors
Expert Opinion on Investigational Drugs, 2001The kynurenine pathway accounts for the metabolism of around 80% of non-protein tryptophan metabolism. It includes both an agonist (quinolinic acid) at NMDA receptors and an antagonist (kynurenic acid). Since their discovery, there has been a major development of kynurenic acid analogues as neuroprotectants for the treatment of stroke and ...
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