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Addiction and the kynurenine pathway: A new dancing couple?
, 2021 Drug use poses a serious threat to health systems throughout the world and the number of consumers rises relentlessly every year. The kynurenine pathway, main pathway of tryptophan degradation, has drawn interest in this field due to its relationship ...
Esther O'Shea, Rebeca Vidal
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Central kynurenine pathway shift with age in women
Journal of Neurochemistry, 2016 Age is considered a dominant risk factor in the development of most neurodegenerative disorders. The kynurenine pathway, a major metabolic pathway of tryptophan is altered in the majority of neurodegenerative disorders.
Gilles J Guillemin, Josien de Bie
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Inhibitors of the kynurenine pathway
European Journal of Medicinal Chemistry, 2000Strokes (intracranial thomboses or haemorrhaging) cause death and disability, but effective treatments are lacking. The metabolism of tryptophan leads to the generation of quinolinic acid, an agonist potentially neurotoxic at glutamate receptors, and kynurenic acid, an antagonist at the same population of receptors.
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The role of the kynurenine pathway in cardiovascular disease
Frontiers in Cardiovascular MedicineThe kynurenine pathway (KP) serves as the primary route for tryptophan metabolism in most mammalian organisms, with its downstream metabolites actively involved in various physiological and pathological processes. Indoleamine 2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO) serve as the initial and pivotal enzymes of the KP, with IDO playing ...
Shi Jiawei, Yuehang Yang
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Kynurenine Pathway and Disease: An Overview
CNS & Neurological Disorders - Drug Targets, 2007Kynurenine pathway is gaining more and more attention every day in biomedical research since this catabolic route for tryptophan decomposition is not only implicated in different neurological disorders, but also possesses neuroactive metabolites with different biological properties, such as pro-oxidant and antioxidant regulators.
Verónica, Pérez-De La Cruz +2 more
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Role of the Kynurenine Pathway in Stroke
2015Stroke is the second and fifth leading cause of death for people aged >60 and 15–59 years, respectively. Many stroke survivors suffer from chronic health problems that necessitate a long-term process of recovery and rehabilitation. There is increasing evidence that inflammation plays an important role in acute ischemic stroke (AIS), indicating the ...
Ormstad, Heidi, Verkerk, Robert
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[Stress and the kynurenine pathway].
Orvosi hetilap, 2015The kynurenine pathway is the main route of tryptophan degradation which gives rise to several neuroactive metabolites. Kynurenic acid is an endogenous antagonist of excitatory receptors, which proved to be neuroprotective in the preclinical settings. Kynurenines have been implicated in the neuroendocrine regulatory processes.
Majláth Zsófia, Vécsei László
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Pharmacology of the kynurenine pathway
International Congress Series, 2007Abstract The kynurenine pathway of tryptophan oxidative metabolism plays a major role in the nervous and immune systems and has been implicated in a range of disease states. Much of the interest in the pathway has been centred around the role of quinolinic acid as an agonist at glutamate receptors sensitive to N -methyl- d -aspartate (NMDA) and ...
Trevor W. Stone, L. Gail Darlington
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Kynurenine Pathway Enzymes in Guinea pigs
2003In some animals, the administration of repeated doses of tryptophan can cause death. It has been reported that guinea pig does not survive repeated doses of tryptophan, due to the absence of the hormonal induction mechanism of liver tryptophan 2,3-dioxygenase (TDO).
ALLEGRI, GRAZIELLA +4 more
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The kynurenine pathway in schizophrenia and bipolar disorder
Neuropharmacology, 2017The kynurenine pathway of tryptophan degradation generates several neuroactive compounds. Of those, kynurenic acid is an N-methyl-d-aspartate (NMDA) and alpha7 nicotinic receptor antagonist. The kynurenic acid hypothesis of schizophrenia is built upon the fact that kynurenic acid blocks glutamate receptors and is elevated in schizophrenia.
Sophie Erhardt +3 more
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