Results 251 to 260 of about 2,991,386 (293)

Targeting the kynurenine pathway

Nature Reviews Drug Discovery
Sarah Crunkhorn
semanticscholar   +2 more sources

Kynurenine pathway metabolites modulated the comorbidity of IBD and depressive symptoms through the immune response.

International Immunopharmacology, 2023
Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, is defined as chronic inflammation in the gastrointestinal tract. Notably, more than 20% of people with IBD experience depressive symptoms.
Weiming Lai, Ziheng Huang, Sheng Li, Xiang-guang Li, Ding Luo   +4 more
semanticscholar   +1 more source

Neurobiological mechanisms in the kynurenine pathway and major depressive disorder

Reviews in the Neurosciences
Major depressive disorder (MDD) is a prevalent psychiatric disorder that has damage to people’s quality of life. Tryptophan is the precursor to serotonin, a critical neurotransmitter in mood modulation. In mammals, most free tryptophan is degraded by the
A. G. Bertollo, M. E. D. Mingoti, Z. Ignácio   +2 more
semanticscholar   +1 more source

The kynurenine pathway in major depression: What we know and where to next.

Neuroscience and Biobehavioral Reviews, 2021
Major depression is a serious psychiatric disorder, occurring in up to 20% of the population. Despite its devastating burden, the neurobiological changes associated with depression are not fully understood.
Samara J. Brown, Xu-Feng Huang, Kelly A. Newell   +2 more
semanticscholar   +1 more source

Minocycline, a classic antibiotic, exerts psychotropic effects by normalizing microglial neuroinflammation-evoked tryptophan-kynurenine pathway dysregulation in chronically stressed male mice.

Brain, behavior, and immunity, 2022
The dysregulation of tryptophan-kynurenine pathway (TKP) is extensively involved in the pathophysiology of Alzheimer's disease, depression, and neurodegenerative disorders. Minocycline, a classic antibiotic, may exert psychotropic effects associated with
Dan Cheng, Zongshi Qin, Yu Zheng, Jun Xie, Sui Liang, Jialing Zhang, Yibin Feng, Zhang-Jin Zhang   +7 more
semanticscholar   +1 more source

Prebiotic and probiotic supplementation and the tryptophan-kynurenine pathway: A systematic review and meta analysis.

Neuroscience and Biobehavioral Reviews, 2021
This systematic review aimed to synthesise the results from studies investigating the effects of prebiotics and probiotics on kynurenine pathway metabolism.
Terry Purton, L. Staskova, M. Lane, S. Dawson, Madeline L. West, J. Firth, G. Clarke, J. Cryan, M. Berk, A. O'Neil, O. Dean, A. Hadi, C. Honan, W. Marx   +13 more
semanticscholar   +1 more source

The Interrelation between Oxidative Stress, Depression and Inflammation through the Kynurenine Pathway.

Current Topics in Medicinal Chemistry, 2022
The prevalence of depression has increased dramatically over the past few decades. Although depression is categorized as a brain disorder, its symptomatology includes some behaviors that also occur during chronic inflammatory stress.
H. Sipahi, Ayse Feruze Mat, Yagmur Ozhan, Ahmet Aydın   +3 more
semanticscholar   +1 more source

Inhibitors of the kynurenine pathway

European Journal of Medicinal Chemistry, 2000
Strokes (intracranial thomboses or haemorrhaging) cause death and disability, but effective treatments are lacking. The metabolism of tryptophan leads to the generation of quinolinic acid, an agonist potentially neurotoxic at glutamate receptors, and kynurenic acid, an antagonist at the same population of receptors.
openaire   +2 more sources

Kynurenine Pathway Enzymes in Guinea pigs

2003
In some animals, the administration of repeated doses of tryptophan can cause death. It has been reported that guinea pig does not survive repeated doses of tryptophan, due to the absence of the hormonal induction mechanism of liver tryptophan 2,3-dioxygenase (TDO).
ALLEGRI, GRAZIELLA, COSTA, CARLO VIRGILIO LUIGI, RAGAZZI, EUGENIO, BERTAZZO, ANTONELLA, BIASIOLO M.   +4 more
openaire   +3 more sources

Kynurenine pathway abnormalities in Parkinson's disease

Neurology, 1992
We measured metabolites of tyrosine and tryptophan (TRP) in the frontal cortex, putamen (PT), and pars compacta of the substantia nigra (SN) of control and Parkinson's disease (PD) brain tissues. Dopamine concentrations were significantly decreased in the PT and SN of PD tissue, regardless of L-dopa therapy. However, 3-O-methyldopa (3OMD) concentration
T, Ogawa, W R, Matson, M F, Beal, R H, Myers, E D, Bird, P, Milbury, S, Saso   +6 more
openaire   +2 more sources