Results 251 to 260 of about 1,141,006 (274)

Kynurenine pathway abnormalities in Parkinson's disease

Neurology, 1992
We measured metabolites of tyrosine and tryptophan (TRP) in the frontal cortex, putamen (PT), and pars compacta of the substantia nigra (SN) of control and Parkinson's disease (PD) brain tissues. Dopamine concentrations were significantly decreased in the PT and SN of PD tissue, regardless of L-dopa therapy. However, 3-O-methyldopa (3OMD) concentration
T, Ogawa, W R, Matson, M F, Beal, R H, Myers, E D, Bird, P, Milbury, S, Saso   +6 more
openaire   +2 more sources

The Kynurenine Pathway in Brain Tumor Pathogenesis

Cancer Research, 2012
AbstractBrain tumors are among the most common and most chemoresistant tumors. Despite treatment with aggressive treatment strategies, the prognosis for patients harboring malignant gliomas remains dismal. The kynurenine pathway (KP) is the principal route of l-tryptophan catabolism leading to the formation of the essential pyridine nucleotide ...
Seray, Adams, Nady, Braidy, Alban, Bessede, Alban, Bessesde, Bruce J, Brew, Ross, Grant, Charlie, Teo, Gilles J, Guillemin   +7 more
openaire   +2 more sources

Kynurenine Pathway Metabolism in Human Astrocytes

1999
The involvement of astrocytes in Kynurenine pathway (KP) metabolism is still poorly understood. In the present study, we investigated the ability of human fetal astrocytes in vitro to produce quinolinic and picolinic acids using mass spectrometry. In parallel, we estimated the level of expression of five major KP enzymes using RT-PCR.
G J, Guillemin, S J, Kerr, G A, Smythe, P J, Armati, B J, Brew   +4 more
openaire   +2 more sources

Role of Kynurenine Pathway in Oxidative Stress during Neurodegenerative Disorders

Cells, 2021
Anna Krupa, Adrian Mor, Dariusz Pawlak   +2 more
exaly  

Dietary Kynurenine Pathway Metabolites—Source, Fate, and Chromatographic Determinations

International Journal of Molecular Sciences, 2023
Ilona Sadok, Katarzyna Jędruchniewicz
exaly  

The Footprint of Kynurenine Pathway in Cardiovascular Diseases

International Journal of Tryptophan Research, 2022
Moein Ala, Seyed Parsa Eftekhar
exaly  

Neuroinflammation and the Kynurenine Pathway in CNS Disease: Molecular Mechanisms and Therapeutic Implications

Cells, 2021
Mustafa Mithaiwala, Jason C O'Connor, Jason C O’Connor   +2 more
exaly  

Gut microbiota, kynurenine pathway and mental disorders – Review

Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2021
Magdalena Więdłocha, Agata Szulc
exaly  

Kynurenine Pathway

2006
openaire   +2 more sources

Dysregulation of kynurenine pathway and potential dynamic changes of kynurenine in schizophrenia: A systematic review and meta-analysis

Neuroscience and Biobehavioral Reviews, 2021
Bing Cao, Zihang Pan, Yan Chen
exaly