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Role of the Kynurenine Pathway in Stroke
2015Stroke is the second and fifth leading cause of death for people aged >60 and 15–59 years, respectively. Many stroke survivors suffer from chronic health problems that necessitate a long-term process of recovery and rehabilitation. There is increasing evidence that inflammation plays an important role in acute ischemic stroke (AIS), indicating the ...
Ormstad, Heidi, Verkerk, Robert
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[Stress and the kynurenine pathway].
Orvosi hetilap, 2015The kynurenine pathway is the main route of tryptophan degradation which gives rise to several neuroactive metabolites. Kynurenic acid is an endogenous antagonist of excitatory receptors, which proved to be neuroprotective in the preclinical settings. Kynurenines have been implicated in the neuroendocrine regulatory processes.
Majláth Zsófia, Vécsei László
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Quantitative analysis of the Kynurenine pathway
Brain, Behavior, and Immunity, 2013The Kynurenine (KYN) pathway of the tryptophan (TRP) metabolism comprises several highly important key interfaces in the functional interplay between immune system, endocrine system and neurotransmitter system. The first step in this pathway is mediated by two enzymes: TDO and IDO; the activity of TDO is regulated by glucocorticoids, while distinct ...
G.A. Schütze +2 more
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The kynurenine pathway in schizophrenia and bipolar disorder
Neuropharmacology, 2017The kynurenine pathway of tryptophan degradation generates several neuroactive compounds. Of those, kynurenic acid is an N-methyl-d-aspartate (NMDA) and alpha7 nicotinic receptor antagonist. The kynurenic acid hypothesis of schizophrenia is built upon the fact that kynurenic acid blocks glutamate receptors and is elevated in schizophrenia.
Sophie Erhardt +3 more
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Kynurenine pathway abnormalities in Parkinson's disease
Neurology, 1992We measured metabolites of tyrosine and tryptophan (TRP) in the frontal cortex, putamen (PT), and pars compacta of the substantia nigra (SN) of control and Parkinson's disease (PD) brain tissues. Dopamine concentrations were significantly decreased in the PT and SN of PD tissue, regardless of L-dopa therapy. However, 3-O-methyldopa (3OMD) concentration
S. Saso +6 more
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Role of the Kynurenine Pathway in Epilepsy
2015A role for the kynurenine pathway (KP) of tryptophan (TRP) metabolism in epilepsy was first discovered when injections of the KP metabolite quinolinic acid (QA) in brain produced seizures in mice (Lapin IP. J Neural Transm. 42(1):37–43;1978). Subsequent studies have reported altered KP metabolites in animal models of epilepsy and in human epilepsy ...
Chaitali Anand +2 more
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Role of Kynurenine Pathway in Infections
2015Tryptophan is an essential amino acid, not only for mammals but also for a broad range of pathogens. The majority of the dietary tryptophan is degraded via the kynurenine pathway to kynurenine and other downstream tryptophan metabolites, together termed “kynurenines”. The induction of the kynurenine pathway in the context of infections is currently the
Walter Däubener, Silvia Kathrin Eller
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Kynurenine Pathway Metabolism in Human Astrocytes
1999The involvement of astrocytes in Kynurenine pathway (KP) metabolism is still poorly understood. In the present study, we investigated the ability of human fetal astrocytes in vitro to produce quinolinic and picolinic acids using mass spectrometry. In parallel, we estimated the level of expression of five major KP enzymes using RT-PCR.
Bruce J. Brew +4 more
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Kynurenine Pathway Enzymes in Brain
1996The kynurenine pathway is the metabolic route by which the essential amino acid, L-tryptophan is catabolized to a number of metabolites for excretion and convertion to nicotinamide-containing nucleotides (Bender, 1982). The liver is viewed as the major source of kynurenine pathway metabolites in blood and urine.
K. Saito, M. P. Heyes
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Role of Kynurenine Pathway in Aging
2015Aging is a degenerative process that affects all living organisms and is characterized by physiological and functional changes that drives to numerous aging-related disorders contributing to death. Cellular changes during the aging process involve oxidative stress, inflammation, mitochondrial dysfunction, and cognitive and immune response decline.
Daniela Ramírez Ortega +4 more
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