Results 101 to 110 of about 22,679 (205)

Targeting cancer metabolism: a therapeutic window opens [PDF]

, 2011
Genetic events in cancer activate signalling pathways that alter cell metabolism. Clinical evidence has linked cell metabolism with cancer outcomes. Together, these observations have raised interest in targeting metabolic enzymes for cancer therapy, but ...
A Clementi, A Dimitrakopoulou-Strauss, A Garten, A Le, A Wolf, A Yalcin, AM Groves, AP Halestrap, AP Pereira da Silva, AS Marsin, B Clem, B Dwarakanath, BA Chabner, BK Mohanti, BR Landau, C Algire, C Derst, C Garcia-Echeverria, C Yang, CH Holdsworth, CM Murray, CS Potten, CV Dang, D Hanahan, D Singh, DA Rew, DA Tennant, DA Tennant, DE Bauer, DK Nomura, DR Wise, DW Parsons, E Eschwege, E Furuta, ED Michelakis, EE Calle, EE Calle, ER Mardis, ES Burgos, G Hatzivassiliou, G Marcucci, G Ollenschlager, GA Spoden, GL Semenza, H Linardou, H Shim, H Yan, HA Hirsch, HR Christofk, HR Christofk, I Maestu, I Papandreou, J Kurhanewicz, J Luo, J Yun, JA Engelman, JA Engelman, JA Menendez, JA Meyerhardt, Jason W Locasale, JB Wang, JD Broome, JG Kidd, JK Jiang, JM Brown, JM Evans, JW Kim, JW Locasale, K Brindle, K Chen, K Duvel, K Holen, K Hosono, K Zaugg, KE Wellen, KH Vousden, KM Kennedy, KS Dimmer, L Dang, L Galluzzi, L Tallal, LG Boros, M Buzzai, M Hasmann, M Ko, M Ookhtens, M Pittelli, M Pollak, M Pollak, M Tahiliani, M Takenaka, M Yuneva, MA Weiser, Matthew G. Vander Heiden, MB Boxer, MB Tessem, MC Li, ME Figueroa, MG Vander Heiden, MG Vander Heiden, MG Vander Heiden, MJ Evans, MJ Holness, MJ Ovens, MJ Seltzer, ML Macheda, ML Tainter, MR Stratton, MS Ardawi, MY El-Mir, N El Mjiyad, N Jaffe, N Normanno, NP Curthoys, NP Manes, NY Kalaany, O Kaplan, P Cocco, P Gao, P Sonveaux, P Thirion, PS Ward, R Chowdhury, R Flavin, R Zhou, R Zoncu, RA Cairns, RA Larson, RB Robey, RB Scott, RE Neuman, RG Jones, RG Maki, RG Verhaak, Richard Possemato, RJ Deberardinis, RJ DeBerardinis, RJ Shaw, RJ Shaw, RL Aft, RM Memmott, S Ben-Haim, S Bonnet, S Bruzzone, S Farber, S Farber, S Gross, S Jiralerspong, S Mazurek, S Stacchiotti, S Telang, SH Jee, SJ Bach, SL Bowker, SM Gallagher, SP Mathupala, T Atsumi, T Cheng, T Shlomi, T Yamamoto, TS Yang, V Chajes, VR Fantin, VT DeVita, W Hu, W Kuo, W Xu, WG Kaelin Jr, Y Kumei, Y Ni, Y Yu, YH Ko   +171 more
core   +1 more source

Systematic Metabolic Engineering and Model‐Guided Optimization for High‐Level Production of L‐Theanine from Xylose in Escherichia coli

Advanced Science, Volume 13, Issue 17, 23 March 2026.
This study is pioneering in constructing the shortest known synthetic pathway for L‐theanine production from xylose within E coli. Through comprehensive metabolic engineering strategies, our engineered strain achieved the highest reported L‐theanine titer from xylose, with a titer of 95.42 g/L, and a yield of 0.55 g/g.
Haolin Han, Boyuan Xue, Guangqi Shan, Meng Meng, Shaojie Wang, Haijia Su   +5 more
wiley   +1 more source

Endophytic l-asparaginase-producing fungi from plants associated with anticancer properties

Journal of Advanced Research, 2015
Endophytes are novel sources of natural bioactive compounds. This study seeks endophytes that produce the anticancer enzyme l-asparaginase, to harness their potential for mass production.
YiingYng Chow, Adeline S.Y. Ting
doaj   +1 more source

Micro/Nanorobot for Drug Delivery—A Review of Material Selections

Advanced NanoBiomed Research, Volume 6, Issue 3, March 2026.
This review explores material strategies for biomedical micro/nanorobots, emphasizing their roles in propulsion, navigation, drug delivery, and biodegradability. It highlights advancements in metallic, polymeric, and hybrid materials, while addressing clinical translation challenges such as toxicity, immune response, and manufacturability.
Xiaozhuo Wu, Bingyun Li, Malcolm Xing
wiley   +1 more source

Screening and assay of extracellular enzymes in Phomopsis azadirachtae causing die-​back disease of neem [PDF]

, 2013
Phomopsis azadirachtae is the causal agent of destructive die-​back disease of neem. The mol. mechanism of pathogenicity is not clear. Pectinases, cellulases, hemicellulases and ligninases have been extensively studied because of their plant cell wall ...
Lakshmeesha, T.R., Mohammed Shafi Sofi, ., Sateesh, M.K., Vedamurthy, A.K., Vedashree, S.   +4 more
core  

Cancer Cell Metabolism: One Hallmark, Many Faces [PDF]

, 2012
Cancer cells must rewire cellular metabolism to satisfy the demands of growth and proliferation. Although many of the metabolic alterations are largely similar to those in normal proliferating cells, they are aberrantly driven in cancer by a combination ...
Cantor, Jason R., Sabatini, David
core   +2 more sources

A Multicenter Survival Analysis of Adults Type B‐Acute Lymphoblastic Leukemia in Ecuador. A Retrospective Study of the Real World

Cancer Medicine, Volume 15, Issue 3, March 2026.
Analysis of adults type b‐acute lymphoblastic leukemia in ecuador. This demonstrates inferior response and survival outcomes for b‐all in Ecuador and can serve as a reference to Latin America countries due to geographic, racial and socioeconomic similarities.
Brenner Sabando, Jairo Quinonez, Andrés Orquera, Danilo Navarrete, Jhoanna Ramírez, Lorena Sanchez, Teodoro Chisesi, Jorge Oliveros, María A. Pacheco, María C. Trujillo, Carlos Plaza, Rafael Lochamin, D. Jimmy Martin   +12 more
wiley   +1 more source

Considerations for Menstrual Suppression in Patients With Hematologic Malignancies

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 46, Issue 3, March 2026.
ABSTRACT Patients who menstruate during treatment for hematologic malignancies have a higher risk of heavy vaginal bleeding due to thrombocytopenia caused by malignancy and myelosuppressive chemotherapy. Heavy menstrual bleeding is associated with significant morbidity in this patient population, and menstrual suppression is a standard of supportive ...
Sahaana Veeravalli, Allison Schepers, Lydia L. Benitez, Martina S. Fraga   +3 more
wiley   +1 more source

Isolation and Identification of L-asparaginase producing Erwinia strains which isolated from Potato Farms

Biological Journal of Microorganism, 2016
Introduction: L-Asparaginase can be effectively used for the treatment of lymphoblastic leukemia. The rapid growth of cancer cells are needed for L-asparagine abundant storage.
Arastoo Badoei-Dalfard, Zahra Karami, Narjes Ramezani–pour   +2 more
doaj  

Purification, characterization and immunogenicity assessment of glutaminase free L-asparaginase from Streptomyces brollosae NEAE-115

BMC Pharmacology and Toxicology, 2018
Background L-asparaginase is a potential therapeutic enzyme widely used in the chemotherapy protocols of pediatric and adult patients with acute lymphoblastic leukemia. However, its use has been limited by a high rate of hypersensitivity in the long-term
Noura El-Ahmady El-Naggar, Sahar F. Deraz, Sara M. El-Ewasy, Ghada M. Suddek   +3 more
doaj   +1 more source