Results 21 to 30 of about 73,863 (280)

Endothelium-dependent vasorelaxation induced by L-carnitine in isolated aorta from normotensive and hypertensive rats [PDF]

, 2002
The aim of this work was to investigate the mechanism of the vasodilatory effect induced by L- carnitine. Relaxation produced by L-carnitine was studied in rat aortic rings with and without functional endothelium, pre-contracted with phenylephrine by ...
Bueno, Rosario, Herrera González, María Dolores, Marhuenda Requena, Elisa, Pérez Guerrero, María Concepción, Vázquez Cueto, Carmen María, Álvarez de Sotomayor Paz, María   +5 more
core   +1 more source

Essential lipid autacoids rewire mitochondrial energy efficiency in metabolic dysfunction‐associated fatty liver disease

Hepatology, EarlyView., 2022
Increased liver content of DHA‐derived small lipid autacoids (i.e resolvin D1 and maresin 1) associates with enhanced mitochondrial oxidative phosphorylation, fatty acid β‐oxidation and bioenergetic metabolic flux. These features provide hepatic protection from steatotic, pro‐inflammatory and fibrogenic insults.
Cristina López‐Vicario, David Sebastián, Mireia Casulleras, Marta Duran‐Güell, Roger Flores‐Costa, Ferran Aguilar, Juan José Lozano, Ingrid W. Zhang, Esther Titos, Jing X. Kang, Antonio Zorzano, Makoto Arita, Joan Clària   +12 more
wiley   +1 more source

The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression

Hepatology, EarlyView., 2022
Loss of NOX4 in HCC tumor cells induces metabolic reprogramming in a Nrf2/MYC‐dependent manner to promote HCC progression. Abstract Background and Aims The NADPH oxidase NOX4 plays a tumor‐suppressor function in HCC. Silencing NOX4 confers higher proliferative and migratory capacity to HCC cells and increases their in vivo tumorigenic potential in ...
Irene Peñuelas‐Haro, Rut Espinosa‐Sotelo, Eva Crosas‐Molist, Macarena Herranz‐Itúrbide, Daniel Caballero‐Díaz, Ania Alay, Xavier Solé, Emilio Ramos, Teresa Serrano, María L. Martínez‐Chantar, Ulla G. Knaus, José M. Cuezva, Antonio Zorzano, Esther Bertran, Isabel Fabregat   +14 more
wiley   +1 more source

Acetyl-l-carnitine for dementia [PDF]

Cochrane Database of Systematic Reviews, 2003
Dementia is a common mental health problem affecting 5% of those over 65. Various pathological processes are linked to memory impairment in dementia, particularly those affecting the cholinergic neurotransmitter system. Acetyl-l-carnitine (ALC) is derived from carnitine and is described as having several properties which may be beneficial in dementia ...
S, Hudson, N, Tabet
openaire   +2 more sources

L-Carnitine and Acetyl-L-Carnitine: Potential Novel Biomarkers for Major Depressive Disorder [PDF]

Frontiers in Psychiatry, 2020
The lack of biomarkers greatly limits the diagnosis and treatment of major depressive disorder (MDD). Endogenous L-carnitine (LC) and its derivative acetyl-L-carnitine (ALC) play antidepressant roles by improving brain energy metabolism, regulating neurotransmitters and neural plasticity.
Li-Juan Nie, Li-Juan Nie, Li-Juan Nie, Li-Juan Nie, Jun Liang, Jun Liang, Jun Liang, Jun Liang, Feng Shan, Feng Shan, Feng Shan, Feng Shan, Bao-Shi Wang, Bao-Shi Wang, Bao-Shi Wang, Bao-Shi Wang, Yuan-Yuan Mu, Yuan-Yuan Mu, Yuan-Yuan Mu, Yuan-Yuan Mu, Xie-Hai Zhou, Xie-Hai Zhou, Xie-Hai Zhou, Xie-Hai Zhou, Qing-Rong Xia, Qing-Rong Xia, Qing-Rong Xia, Qing-Rong Xia   +27 more
openaire   +4 more sources

Influence of L-carnitine on litter characteristics from gilts harvested at day 40, 55, and 70 of gestation [PDF]

, 2005
Swine research, 2005 is known as Swine day, 2005A total of 59 gilts were used to determine the effects of supplemental L-carnitine on reproductive performance. Experimental treatments were arranged in a 2 × 3 factorial with main effects of L-carnitine (0
Brazle, A.E., Brown, K.R., Burkey, T.E., Dritz, Steven S., Goodband, Robert D., Groesbeck, C.N., Johnson, B.J., Minton, J. Ernest, Neill, C.R., Nelssen, Jim L., Schneider, J.D., Tokach, Michael D., Woodworth, J.C.   +12 more
core   +2 more sources

Enhanced mitochondrial activity reshapes a gut microbiota profile that delays NASH progression

Hepatology, EarlyView., 2022
Improved mitochondrial activity, due to the lack of methylation‐controlled J protein (MCJ), creates a specific microbiota signature that when transferred through cecal microbiota transplantation delays NASH progression by restoring the gut‐liver axis and enhancing hepatic fatty acid oxidation.
María Juárez‐Fernández, Naroa Goikoetxea‐Usandizaga, David Porras, María Victoria García‐Mediavilla, Miren Bravo, Marina Serrano‐Maciá, Jorge Simón, Teresa C. Delgado, Sofía Lachiondo‐Ortega, Susana Martínez‐Flórez, Óscar Lorenzo, Mercedes Rincón, Marta Varela‐Rey, Leticia Abecia, Héctor Rodríguez, Juan Anguita, Esther Nistal, María Luz Martínez‐Chantar, Sonia Sánchez‐Campos   +18 more
wiley   +1 more source

L-carnitine and contribution to normal lipid metabolism:evaluation of a health claim pursuant to Article 13(5) of Regulation (EC) No 1924/2006 [PDF]

, 2018
Following an application from Lonza Ltd., submitted for authorisation of a health claim pursuant to Article 13(5) of Regulation (EC) No1924/2006 via the Competent Authority of Germany, the EFSA Panelon Dietetic Products, Nutrition and Allergies (NDA) was
, Bresson, Jean Louis, Burlingame, Barbara, Dean, Tara, Fairweather-Tait, Susan, Heinonen, Marina, Hirsch-Ernst, Karen Ildico, Mangelsdorf, Inge, Martin, Ambroise, McArdle, Harry J., Naska, Androniki, Neuhäuser-Berthold, Monika, Nowicka, Grażyna, Pentieva, Kristina, Sanz, Yolanda, Siani, Alfonso, Sjödin, Anders, Stern, Martin, Strain, Sean (J. J.)., Tomé, Daniel, Turck, Dominique, Van Loveren, Henk, Vinceti, Marco, Willatts, Peter   +23 more
core   +4 more sources

RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease

Hepatology, EarlyView., 2022
RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease. Abstract Background and Aims Receptor‐interacting protein kinase 3 (RIPK3) mediates NAFLD progression, but its metabolic function is unclear. Here, we aimed to investigate the role of RIPK3 in modulating mitochondria function, coupled with lipid droplet (LD)
Marta B. Afonso, Tawhidul Islam, Julie Magusto, Ricardo Amorim, Véronique Lenoir, Rui F. Simões, José Teixeira, Liana C. Silva, Dominique Wendum, Isabelle Jéru, Corinne Vigouroux, Rui E. Castro, Paulo J. Oliveira, Carina Prip‐Buus, Vlad Ratziu, Jérémie Gautheron, Cecília M. P. Rodrigues   +16 more
wiley   +1 more source

Effective dosing of L-carnitine in the secondary prevention of cardiovascular disease: a systematic review and meta-analysis [PDF]

, 2014
BACKGROUND: L-carnitine supplementation has been associated with a significant reduction in all-cause mortality, ventricular arrhythmia, and angina in the setting of acute myocardial infarction (MI).
Hui Li, Ruiping Shang, Zhiqi Sun
core   +2 more sources